6I8M,3C49


Conserved Protein Domain Family
PARP_reg

?
pfam02877: PARP_reg (This model is not part of the current CDD release)
Poly(ADP-ribose) polymerase, regulatory domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
Statistics
?
PSSM-Id: 515246
Aligned: 141 rows
Threshold Bit Score: 78.7222
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6I8M_A         12 SKLAKPIQDLIKMIFDVE---SMKKAMVEFEIDLQKMPLGKLSKRQIQSAYSILNEVQQAVSDGGS-------------- 74   chicken
EFJ30299      616 SNLHPRVVSLMKMLFDIE---TYKSAMLEFEINPNEMPLGKLTKAHIAKGFDVLTRIQNVLKREQQdp------------ 680 
EFJ38160      343 CKLDPKVARFCKCLFSQA---VYRHAMFEMGINSPELPLGSLSEFHFKRCEECLLEFADFLQKESDsk------------ 407 
XP_002523787  452 SKLEPQLAYFMKILCSQE---IYRYALMEMGLDPPELPMGMLSDLHLKRCEEVLLQFVEAVKSMKGtgq----------- 517 
CBI28338      466 CKLEPLVANFMKVLCSQE---IYRYAMMEMGLDSPDLPMGMLSNIHLKRCEEVLLNFIETVKSIKEmdi----------- 531 
Q9FK91        450 CKLDSFVANFIKVLCGQE---IYNYALMELGLDPPDLPMGMLTDIHLKRCEEVLLEFVEKVKTTKEtgq----------- 515  thale cress
XP_010652358  647 SQLAPQVVELMKMLFNVE---TYRSAMMEFEINMSEMPLGKLSKSNIQKGFEALTEIQNLLNSNAHdps----------- 712 
Q55GU8        307 SYIETNVSKLMDIIYKEAskcLIKNFSVEVTENGIETQLGALSMAQIEEAKSILNEINNVLNKDGId------------- 373  Dictyostelium...
XP_004363442  321 TQLPEEVKQLVAAIFQDA---HAHL------IRTVDMPLGTLSVPQIEKGLTILGTIEGILLKQTKsdgaqmddngdnan 391 
Q54E42       2145 SQLPKELYDVMAQFCNVE---SISHQLKNLKIDTDIMPLGRISKDLIQKAITVLGKLSEAVEQIRLieeheankrassft 2221 Dictyostelium...
6I8M_A         75 ----------------------------------ESQILDLSNRFYTLIPHdf--gMKK-P---PLLSNLEYIQ-AKVQM 113  chicken
EFJ30299      681 --------------------------------rrQVELIDGSNQFNTLIPSt-------hP---TLIDDEDVLK-TKIQM 717 
EFJ38160      408 --------------------------------khEQMCLDFSNKWFSLVPS-------ThP---TVISDIAHLTeLGASV 445 
XP_002523787  518 --------------------------------kaEAVWSDYSQRWFTLMHS-------TrP---LILRDYDELAdNVAAA 555 
CBI28338      532 --------------------------------kaKATWSDFSQRWFTLLHS-------TrP---FIFRDHQEIAdHAAAA 569 
Q9FK91        516 --------------------------------kaEAMWADFSSRWFSLMHS-------TrP---MRLHDVNELAdHAASA 553  thale cress
XP_010652358  713 --------------------------------fkESLIVDASNRFFTVIPSi-------hP---HVIRDEDDFK-SKVKM 749 
Q55GU8        374 ---------------------------------nQENLEMLSSRFYQLVPSkistkKNR-DsskSVINSFESLN-QLSEL 418  Dictyostelium...
XP_004363442  392 g-------------------tsasassssssspmPKGLSALSNEFYATIPH---------KspaNPVTSLQAVT-DKQEL 442 
Q54E42       2222 nattvgsgvsgsggdststtdkpeepnfpplndvKESLIKLSNEFYELIPH-----SNFsTermVILKSAKEIT-AKTTL 2295 Dictyostelium...
6I8M_A        114 LDNLLDIEVAYSLLRGGNEDGDKDPIDINY 143  chicken
EFJ30299      718 LEALRDIEIASQLIKSADEDDESDPLDVHY 747 
EFJ38160      446 LESLKAISVASHIIGDMTGDTLDDPLSDRY 475 
XP_002523787  556 FETVRDINVASRLIGDMSGSTLDDPLSDRY 585 
CBI28338      570 LEIVRDITVASHLVGDLTGSTLDDPLFDRY 599 
Q9FK91        554 FETVRDINTASRLIGDMRGDTLDDPLSDRY 583  thale cress
XP_010652358  750 LEALQDIEIASRLVGFDVDSD--DSLDDKY 777 
Q55GU8        419 MNMMKDLTNSFNSNKTTSESKN--HLDMKY 446  Dictyostelium discoideum AX4
XP_004363442  443 CQLLLDVCAVSETSWLSSSTST--PVEQQY 470 
Q54E42       2296 LQNLDELETVSKILIAAHQNTTMHPYDYCF 2325 Dictyostelium discoideum AX4
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap