5ZI4,2PWZ,1A5Z,3PQD


Conserved Protein Domain Family
Ldh_1_C

?
pfam02866: Ldh_1_C 
Click on image for an interactive view with Cn3D
lactate/malate dehydrogenase, alpha/beta C-terminal domain
L-lactate dehydrogenases are metabolic enzymes which catalyze the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyze the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Statistics
?
PSSM-Id: 397136
Aligned: 15 rows
Threshold Bit Score: 146.738
Threshold Setting Gi: 1498802526
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5ZI4_A   148 TNLDLVRAETFlvdylmlknpkIGQ---EQDK-TTMHR---KVTVIGGHSG----------ETIIPI--ITDKSLVFQlD 208 baker's yeast
P14152   156 TRLDHNRAKSQ-----------IAL---KLGVtADDVK---NVIIWGNHSStqypdvnhakVKLQGKevGVYEALKDD-S 217 house mouse
P17505   165 TTLDSIRAARF-----------ISE---VENT-DPTQE---RVNVIGGHSG----------ITIIPLisQTNH-KLMS-D 214 Saccharomyces cerev...
2PWZ_C   147 TTLDIIRSNTF-----------VAE---LKGK-QPGEV---EVPVIGGHSG----------VTILPLlsQVPG-VSFT-E 196 Escherichia coli K-12
P22133   179 TKLDIVRASTF-----------LREiniESGL-TPRVNsmpDVPVIGGHSG----------ETIIPLfsQSNFLSRLN-E 235 Saccharomyces cerev...
Q5SKV7   156 TRLDHNRAKAQ-----------LAK---KTGTgVDRIR---RMTVWGNHSStmfpdlfhaeVDGRPA-----LELVDM-E 212 Thermus thermophilu...
CDS36943 156 sRLDHNRAIYQ-----------VAA---KAGVpNTCVK---NVCVWGNHSNkqfpdlshavVTKDGKqhPAKELINDE-K 217 Echinococcus multil...
1A5Z_A   142 TVLDTARLRTL-----------IAQ---HCGF-SPRSV---HVYVIGEHGDsevpvwsgamIGGIPLqnMCQVCQKCD-S 202 Thermotoga maritima
3PQD_D   148 TTLDSARFRFM-----------LSE---YFGA-APQNV---HAHIIGEHGDtelpvwshanVGGVPVseLVEKNDAYK-Q 208 Bacillus subtilis
Q01462   148 TSLDTARFRQA-----------LAE---KVDV-DARSI---HAYIMGEHGDsefavwshanVAGVKLeqWFQENDYLN-E 208 Lactococcus lactis ...
5ZI4_A   209 KQYEHFIHRVQFGGDEIVKAKQgaGSATLSMAFAGAK----FAEEVLRSFhnekpeTESLSAFVYLPGLkNGKKAQqlvg 284 baker's yeast
P14152   218 WLKGEFITTVQQRGAAVIKARK--LSSAMSAAKAIAD----HIRDIWFGTp----eGEFVSMGVISDGNsYGVPDD---- 283 house mouse
P17505   215 DKRHELIHRIQFGGDEVVKAKNgaGSATLSMAHAGAK----FANAVLSGF------KGE--RDVIEPSF-VDSPLFkse- 280 Saccharomyces cerev...
2PWZ_C   197 QEVADLTKRIQNAGTEVVEAKAggGSATLSMGQAAAR----FGLSLVRAL------QGE--QGVVECAY-VEGDGQy--- 260 Escherichia coli K-12
P22133   236 DQLKYLIHRVQYGGDEVVKAKNgkGSATLSMAHAGYKcvvqFVSLLLGNI------EQI--HGTY---Y-VPLKDAnnfp 303 Saccharomyces cerev...
Q5SKV7   213 WYEKVFIPTVAQRGAAIIQARG--ASSAASAANAAIE----HIRDWALGTp----eGDWVSMAVPSQGE-YGIPEG---- 277 Thermus thermophilu...
CDS36943 218 WVKEVFTPCVQNRGAAVIGLRK--LSSAASAAKAIVD----QMRDWWFGTk----eGEWVSMSVYSTGDhYGAPKD---- 283 Echinococcus multil...
1A5Z_A   203 KILENFAEKTKRAAYEIIERK---GATHYAIALAVAD----IVESIFFDE------KRVLTLSVYLEDY-LGVKDl---- 264 Thermotoga maritima
3PQD_D   209 EELDQIVDDVKNAAYHIIEKK---GATYYGVAMSLAR----ITKAILHNE------NSILTVSTYLDGQ-YGADD----- 269 Bacillus subtilis
Q01462   209 AEIVELFESVRDAAYSIIAKK---GATFYGVAVALAR----ITKAILDDE------HAVLPVSVFQDGQ-YGVSD----- 269 Lactococcus lactis ...
5ZI4_A   285 -----------dnsiEYFSLPIVLR-NGsvvsiDTSV-LE--K-LSPREEQLVN-TAVKELRKNIEKGKSFI 339 baker's yeast
P14152   284 ---------------LLYSFPVVIK-NK-----TWKF-VEglP-INDFSREKMD-LTAKELTEEKETAFEFL 331 house mouse
P17505   281 -------------giEFFASPVTLGpDG-----IEKI-HPigE-LSSEEEEMLQ-KCKETLKKNIEKGVNFV 331 Saccharomyces cerevisiae S288C
2PWZ_C   261 --------------aRFFSQPLLLGkNG-----VEER-KSigT-LSAFEQNALE-GMLDTLKKDIALGEEFV 310 Escherichia coli K-12
P22133   304 iapgadqllplvdgaDYFAIPLTITtKG-----VSYVdYDivNrMNDMERNQMLpICVSQLKKNIDKGLEFV 370 Saccharomyces cerevisiae S288C
Q5SKV7   278 ---------------IVYSFPVTAK-DG-----AYRV-VEglE-INEFARKRME-ITAQELLDEMEQVKAlg 325 Thermus thermophilus HB8
CDS36943 284 ---------------IYFSFPVTIK-DG-----HYKV-VDglS-MDEWSRSLFK-LSADELVDEREVALAsf 331 Echinococcus multilocularis
1A5Z_A   265 ---------------CIS-VPVTLGkHG-----VERI-LEl-N-LNEEELEAFR-KSASILKNAINEITAEE 311 Thermotoga maritima
3PQD_D   270 ---------------VYIGVPAVVNrGG-----IAGI-TEl-N-LNEKEKEQFL-HSAGVLKNILKPHFAEQ 317 Bacillus subtilis
Q01462   270 ---------------CYLGQPAVVGaEG-----VVNP-IHi-P-LNDAEMQKME-ASGAQLKAIIDEAFAKE 317 Lactococcus lactis subsp. l...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap