Conserved Protein Domain Family
DDHD

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pfam02862: DDHD (This model is not part of the current CDD release)
DDHD domain
The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.
Statistics
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PSSM-Id: 515233
Aligned: 137 rows
Threshold Bit Score: 99.4516
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IAY0        222 LKSKIHYLFMLGSPL-------------SALLSLYkpeyindGLKlnnGL------------------------------ 258  Plasmodium fa...
XP_003345446  755 FEFDTTNLFLLGSPA-------------AFFLLLE-------RGSlvpRRgrlkpgadaadtlnk------divgdigrf 808 
Q6C3H4        677 FCFNTSNLFLVGSPV-------------GFFMLLH-------NANfkaRSeengpqy----------------------- 713  Yarrowia lipo...
XP_011388591  664 LHFNVKNLFLIGSPV-------------AFFFHLN-------GGQliaRSgtqrhpnndsdav----------dgdtgry 713 
XP_016290775  535 LHFNVKNLFFIGSPV-------------AFFFHLD-------GGQliaRSgtdrhpdnhgdal----------dgekgry 584 
KDE07713      483 FVFDTRLFILVGSPL-------------AFFLHLG-------QGQliaRRgrartqnvgrdia----------ldragry 532 
XP_003889621  614 FCFDTSKVFLVGSPV-------------AFFFHLH-------RAQliaREgvssstrldsknsaewrkanrvstdevgqy 673 
XP_007411848  621 FCFGTETVFLVGSPLvigwlmslklqqvAFFFHLH-------RAQliaRLpsnkasdpssewkrkk----riatdevgry 689 
XP_016293157  788 LLFNTHSFFAVGAPI-------------ALFFVLH-------RAQliaRSgrvrssrfvqdkpgv-------tldqagqy 840 
XP_011391428  776 LLFNTHSFFAVGAPV-------------ALFFVLH-------RAQliaRSgvvrssrfvrdepgi-------tlngegrf 828 
Q8IAY0        259 ------KFYNIFHGFDPVAFRIEPLIYPGI-KNIp-----------EPVLINYWRNnGARYw------------------ 302  Plasmodium fa...
XP_003345446  809 gciavdNIYNILAKEDPIAYLLNGTIDPVYaSSL------------KTAYVPTFTTsFFKSm------------------ 858 
Q6C3H4        714 gclavkNLYNVINFSDPIAYLLNPTVDTDLaENI------------ETANVPTEKNfPLEGedeswik----------fp 771  Yarrowia lipo...
XP_011388591  714 gclaaeNVYNIFNPNDPVAFKLAPTVDSAYaKLI------------KPVAIESAAEaVLRTl------------------ 763 
XP_016290775  585 gclateNVYNIFNPNDPVAFQLAPTVDSAYaKLI------------KPISIESATEvILRSl------------------ 634 
KDE07713      533 gcmaidAVYNVYHETDPVAFALNATVDREYaKLI------------KPIAIPSTNStLFENl------------------ 582 
XP_003889621  674 gclaaeTIYSVYISTDPVAYSMNACVDCGHsKRI------------KPIDAHSFTKkF---------------------- 719 
XP_007411848  690 gclaaeNVYNVYISTDPVSYCMNACVDSKFvNKFctmstmiyakqiRPIDVTSMTQnILT-------------------- 749 
XP_016293157  841 gclavtQFYNIWNQYDPVATRATPCVDVQYaKLL------------KPVPLNKAIRsVLRAdaeadnhdiaedggsqsfg 908 
XP_011391428  829 gclavtSFYNIWNQYDPVATRASPCVDVQYaKQL------------KPVPLNKAIRsILRAdpeaenhdiaedggtwsfg 896 
Q8IAY0        303 ----FEWDKNMQNAKLAIVQNLNDFTSAITNGf------------------------------------yK-----Flgk 337  Plasmodium fa...
XP_003345446  859 ----SDSLRGLAGL------------------------------------------------------------------ 868 
Q6C3H4        772 vkfpFWSPSGTPSVEEKESDKGVKAVKDL--------------------------------------------------- 800  Yarrowia lipo...
XP_011388591  764 ----SLPRMSVTQVFEKYKDHPFQGVGKIIRQarilekddtalpcdlspdeqrhvsrrekgkciveasdyIqtvrkWq-- 837 
XP_016290775  635 ----SLPRISVSRVFEKYKDRPFQGVGKIVRQarilenkqdalpsdlseleekhlkqrklgkrivdasdyIqtvrkWh-- 708 
KDE07713      583 ----SDTYSRISNVLDISRFWSSP-------------------------------------------------------- 602 
XP_003889621  720 -------------LETMRRKRPIAEPEST--------------------------------------------------- 735 
XP_007411848  750 ------LFESRASINEKRGIKHIGSLASISSIilkrsswfrs-------------------pkpdckpdtPai--eEl-- 800 
XP_016293157  909 sgreGDSDSGIAKRKAAAAKRTKGFFGSWSKKageaaktvnqarlaans-----iakaaaegdgdqtgdeSvprssMd-- 981 
XP_011391428  897 sgnaADPDARVAKRKAAAVKRTKGFFGTWSRRteaataprktqav------------eeddgekigdddsAlr-ssMd-- 961 
Q8IAY0        338 nenndedqstlnknicynkceskdinifllkVKENQRKIALQKKKIHRynkknnitykenvaekknahynsihNINDNni 417  Plasmodium fa...
XP_003345446  869 ----------------------------------STTSAPTSSNPSNPsdsnhsndqpgssqmlstskpptflRLPSQ-- 912 
Q6C3H4        801 -------------------------------SEGSKDATDTKDLEEFSasevkgslkprprsdstksdksmssRLSGIfs 849  Yarrowia lipo...
XP_011388591  838 -------------------------------HLRDASATACDLGAAGSaremeterasrl-trrtrsttliwdRSSA--- 882 
XP_016290775  709 -------------------------------KLQNADPGSADAGAATPekreleteegrrkkmlqpetalrtsSIPGEe- 756 
KDE07713      603 -------------------------------EKNEALEGSKNEGPPGSnsgteaysaekvgrgqsssnlaakpKMPARr- 650 
XP_003889621  736 -------------------------------LTRNVSLSSLSSLVASSwmgstkkrepddlintnngnpqatlIGDVIrp 784 
XP_007411848  801 -------------------------------LIETNGAEDAESTQEQQadrkrpisrtsnk------------------- 830 
XP_016293157  982 -------------------------------VSDTDESKGSR-QVEDLrskiaakareeekrkverdriadedRK----- 1024
XP_011391428  962 -------------------------------VSETEEAREARTEAESLrskfaakareeedrkeerkriadeeRK----- 1005
Q8IAY0        418 cdnicdnicenicdnicDNIRDnirdnmrdnirdnicdhhlndisyndedsqdtyfghekykrkydhndeqkkegtyysk 497  Plasmodium fa...
XP_003345446  913 -----------------LE------------------------------------------------------------- 914 
Q6C3H4        850 srpks------plspnaRKTEHkkspmatsgpfspqevspkdevp----------------------------------- 888  Yarrowia lipo...
XP_011388591      --------------------------------------------------------------------------------     
XP_016290775  757 -----------------AD------------------------------------------------------------- 758 
KDE07713      651 ----------------pTNKR----------------------------------------------------------- 655 
XP_003889621  785 s-------------cspLPPSDppprpprptsmini-------------------------------------------- 807 
XP_007411848  831 -----qnssvsetinvkK-------------------------------------------------------------- 843 
XP_016293157 1025 -----------------K-------------------------------------------------------------- 1025
XP_011391428 1006 -----------------K-------------------------------------------------------------- 1006
Q8IAY0        498 eenssyidstksicasqdsnseysffdhelSDNSNNlYEENRRNYDDHNKKRESICNSNNINDALniRYDYQLQ-EFI-M 575  Plasmodium fa...
XP_003345446  915 ----------------------------------LE-------VHDF-SREEVAEKKAFLLNDNG--QIDYYLKsGGGpL 950 
Q6C3H4        889 -------iftptpvkpmnasveiggsligeGNLTSSpPKSIPLQKRDFAREHQAEQQMQGLNDNG--QIDWIVPlTGA-L 958  Yarrowia lipo...
XP_011388591  883 -----------------------------------R----------N-------VVS-APLNPHG--CIDYHLSeSISl- 906 
XP_016290775  759 ----------------------------------DK------HDFDL-DSLERAERRFRALNPHG--CIDYHLSaSISl- 794 
KDE07713      656 --------------------------------MPSE----MPMGKREFESVSRAEQRFKALNPQG--CIDFYMPaEGi-- 695 
XP_003889621  808 ----------------gwsdlvrkrtrvftASSSTEnIRDEHLKKSKHGEDTLGRMRFLGLNPTG--SVDFVIPsLGl-- 867 
XP_007411848  844 ----------------------------------RR--------DDV----SDAQLRFEALNPTG--CVDFVIPsLGm-- 873 
XP_016293157 1026 ----------------------------------GI-------SDKR---KARAEARLRALNPLH--RIDYYMPvEG--Y 1057
XP_011391428 1007 ----------------------------------GI-------SAKR---QARAEARLRALNPLH--RIDFYMPvEG--Y 1038
Q8IAY0        576 EHy---iYPLAVAKSHFNYFIIKDISFFILKELI 606  Plasmodium falciparum 3D7
XP_003345446  951 EI-----QYLNMLSAHTSYWYNMDLIRFLCIEIG 979 
Q6C3H4        959 EN-----QYVSMITAHSNYWDNKDLARMCAIESC 987  Yarrowia lipolytica
XP_011388591  907 ------sAYLDALGAHLCYWTHRDFAVFVLTQLF 934 
XP_016290775  795 ------sGYLDMFGAHLSYWGHRDFAVFILTQLF 822 
KDE07713      696 ------nQYIDALSSHASYWSSDSVATFVLTQLF 723 
XP_003889621  868 ------nQYVDMVTAHAAYWTDNRFARLVLIGLF 895 
XP_007411848  874 ------nQYLDMVTAHAAYWSEPRFAKFVLTQLL 901 
XP_016293157 1058 SLlssinQYAELMTAHMSYWTKVDFADFLITQLM 1091
XP_011391428 1039 SLlssinQYAELMTAHMSYWTKVDFADFLITQLM 1072
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