1HU3,3RK6,1UW4,3FEX,6N7P,4LUN,2VSX,4IUL


Conserved Protein Domain Family
MIF4G

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pfam02854: MIF4G 
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MIF4G domain
MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Statistics
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PSSM-Id: 397130
Aligned: 34 rows
Threshold Bit Score: 79.7144
Threshold Setting Gi: 15214089
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HU3_A   12 FRKVRSILNKLT---PQXFNQLXKQVSGLTVDT------EERLKGVIDLVFEKAIDEP--SFSVAYANXCRCLVTLKVpx 80   human
1UW4_B    9 RKLLYKDLSKVT------TEKVLRQMRKLPWQD------QEVKDYVICCMINIWNVKY--NSIHCVANLLAGLVLYQE-- 72   human
F4IUX6  671 QYVRKLLFSDLD---KDSIANVLKQLRKLPWSE--------CEQYILKCFMKVHKGKY--GQIHLIASLTSGLSRHHD-- 735  thale cress
O13824  649 EFLYDLIQIRLK---DDNVFPTLLLLRKFDWKD--------DYQILYNTIMEVWNIKY--NSLNALARLLSALYKFHP-- 713  Schizosaccharomyces...
O14253   34 AARIKKDITFLAd--PRGNSVAADDINYVAMSLsreandPETISTILDCIQTTAFIIP--VKIPHLATLIIRASLRVP-- 107  Schizosaccharomyces...
Q9SIU2    8 LLRIGEKGPEYGt--SSDYKDHIETCFGVIRREi-----ERSGDQVLPFLLQCAEQLP--HKIPLYGTLIGLLNLENE-- 76   thale cress
O01763   28 EKKLQGVIGKVGentGSSIECNLDKLTAFLHDDle-----kYRASIIDIIAGCAIYLP--NRVTVYTTLVGLLNSKNF-- 98   Caenorhabditis elegans
3FEX_A   28 EDHLESLICKVGeksACSLESNLEGLAGVLEADl-----PNYKSKILRLLCTVARLLP--EKLTIYTTLVGLLNARNY-- 98   human
6N7P_X   36 CKEMMPDIRTIGe-sVKAFEDDIKFLSEAIMNEygh--edYFNNALLSTLNAVVVEQP--QKQAAIALLTMVVNSKNN-- 108  Saccharomyces cerev...
Q9W3L1  104 LKKNTAFVKKLK----LFTATQLDGLLREISAL-------NLSKYISEICAALVEAKLkmTDVPAVVTLASRLHCTYA-- 170  fruit fly
1HU3_A   81 adkpgntvNFRKLLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhDELEEAKDKARRRSIGNIKFIGELFKLK 160  human
1UW4_B   73 --------DVGIHVVDGVLEDIRL-----------------------------GMEVNQPKFNQRRISSAKFLGELYNYR 115  human
F4IUX6  736 --------EFVVAVVDEVLEEIRV-----------------------------GLELNEYGAQQKRLAHMRFLGELYNYE 778  thale cress
O13824  714 --------EFCIHVIDDTLESLFS-----------------------------AVNNSDHVEKQKRLAQARFISELCVIH 756  Schizosaccharomyces...
O14253  108 --------LILEKAAAYFCLQYFT-------------------------------NLNSFLYYEAKVDLRMLICMSFALQ 148  Schizosaccharomyces...
Q9SIU2   77 --------DFVQKLVESVHANFQV--------------------------------ALDSGNCNSIRILLRFMTSLLCSK 116  thale cress
O01763   99 --------NFGGDVVEKLISEQQD--------------------------------LLSKQKYQEAQNLAIFLCDLGNSG 138  Caenorhabditis elegans
3FEX_A   99 --------NFGGEFVEAMIRQLKE--------------------------------SLKANNYNEAVYLVRFLSDLVNCH 138  human
6N7P_X  109 --------VAGKSIINYFFEELQKWckqt-------------------yndeFKSTSNETGPWNKIKLILRFLSILSPMF 161  Saccharomyces cerev...
Q9W3L1  171 --------DFDVHFLEAWQKALNI------------------------------KATEKIGNPSKLRVDLRLFAELVSSG 212  fruit fly
1HU3_A  161 XLTEA-IXHDCVVKLLKNHDE------------------ESLECLCRLLTTIGKDLD----FEKAKPRXDQYFNQXEKIV 217  human
1UW4_B  116 MVESA-VIFRTLYSFTSFGVNpdgspss----ldppehlFRIRLVCTILDTCGQYFD----RGSSKRKLDCFLVYFQRYV 186  human
F4IUX6  779 HVDSS-VIFETLYLTLLYGHDtseqevl-----dppedfFRVRMVIILLETCGHYFD----RGSSKKRLDQFLIHFQRYI 848  thale cress
O13824  757 MLDVR-AITNFLFHLLPLEKFesfltmkastltninndmFRLRLIVVVLQTCGPSII----RSKTKKTMLTYLLAYQCYF 831  Schizosaccharomyces...
O14253  149 PGTLK-PLFSLLADAISKETKpsv------------wgdNFLRIILINLPYFIAANN----DLGKKDFANEILDQCEIYV 211  Schizosaccharomyces...
Q9SIU2  117 VIQPA-SLIVVFETLLSSAATtvdeekgn--pswqpqadFYVICILSSLPWGGSELA-----EQVPDEIERVLVGIQAYL 188  thale cress
O01763  139 VLTA--QSIGEYLESFIAAAFeenmp--------qvrndYYIQTVLRCLPWIGKELT-----EKAPEQMENIGEAIGKYL 203  Caenorhabditis elegans
3FEX_A  139 VIAA--PSMVAMFENFVSVTQeedvp--------qvrrdWYVYAFLSSLPWVGKELY-----EKKDAEMDRIFANTESYL 203  human
6N7P_X  162 LVDELiNIYKSLFELSIELNNldpg----------nrvpLSEAIYTNTLLNIPYLFFfnrnNDGLRTKVEELLAYVEQNY 231  Saccharomyces cerev...
Q9W3L1  213 VIQMK-PGLAQLGVVLVHLIAldk------------ddhSNFSIILSFCRHCGEEYA-----GLVPQKMQQLATKYGVEV 274  fruit fly
1HU3_A  218 KE-----------------RKTSSRIRFXLQDVIDLRLCN 240  human
1UW4_B  187 Wwkksle-------vwtkdHPFPIDIDYMISDTLELLRPK 219  human
F4IUX6  849 LSk----------------GHLPLDIEFDLQDLFANLRPN 872  thale cress
O13824  832 LIq----------------PEMPLDMLYEFEDVIGYVRPS 855  Schizosaccharomyces pombe 972h-
O14253  212 RHrkssitls--nplsihdNLSEEELDLLYKQLILSREND 249  Schizosaccharomyces pombe 972h-
Q9SIU2  189 SIrknsstsglnffhngefESSLAEKDFVEDLLDRIQSLA 228  thale cress
O01763  204 ELrnknhval--lqvwregSTDQKQEDYLESLSAQIEALR 241  Caenorhabditis elegans
3FEX_A  204 KRrqkthvp---mlqvwtaDKPHPQEEYLDCLWAQIQKLK 240  human
6N7P_X  232 LVkttdi-------nllreYNGEPPYEMVELVRVVLPNVK 264  Saccharomyces cerevisiae S288C
Q9W3L1  275 PKsd--------------fLTADKQLNLRTMLKGYFKALC 300  fruit fly
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