2YYA,2QK4,2XD4,2IP4,7LVO,3LP8,1GSO


Conserved Protein Domain Family
GARS_N
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pfam02844: GARS_N (This model is not part of the current CDD release)
Phosphoribosylglycinamide synthetase, N domain
Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam00289). This domain is structurally related to the PreATP-grasp domain.
Links
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Statistics
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PSSM-Id: 515227
Aligned: 762 rows
Threshold Bit Score: 60.8185
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YYA_A          1 MKVLVVGNGGREHAIAWKVAQSplvK---ELYVAK--GNAGIWEIAKrVDISPtd--veKLAEFAKN--EGVDFTIVGPE 71  Aquifex aeolicus
18_pfamImport   1 ETVVLIGGGGREHAIARSLAESe-----aRLYACAgnRNPGIAALAD-GFETLdttnptAVRTYADE--VDATLAVVGPE 72 
WP_020447782    3 ETVLLVGGGGREHAIARAVADS---DedvELYAAAsnKNPGIAELSS-GFVTVdetdadAIVDYATS--VGATLAVIGPE 76  Salinarchaeum ...
WP_015409746    3 ETVLLVGGGGREHAIARAVAGSea----aELYACAsnRNPGIASLAE-GYAEIgetdgdSIVEYAES--VGATLAAIGPE 75  Natronomonas m...
WP_011323693    3 ETVLLVGGGGREHAIARAVDDSeh----gTLYACAsnRNPGIDELAA-GYRELdetdaeAVVDYAES--VDATLAAIGPE 75  Natronomonas p...
Q18H71          5 ESVLLIGGGGREHAIAQALTVDsr----cTLYACAgnRNPGITALTA-DFESIpatsvdAIVEYATTdpVNADLAIIGPE 79  Haloquadratum ...
WP_049952563    3 EHVLLIGGGGREHAIARELAASe-----aKLSACAgnRNPGIARLAA-EFETLettdpaAVAEYAEA--IDATIAVVGPE 74  Halostagnicola...
WP_015300708    3 DIVLLIGGGGREHAIARSLADSe-----vDLYACAgnRNPGIAALAT-DFVTLdtsdtdAVVAYAEE--IEATIAVVGPE 74  Halovivax ruber
WP_004214780    3 ETVLLIGGGGREHAIARALENSe-----aDLYACAgnRNPGIARIAD-GFETLettnpkAVLEFAEE--VNATIAVVGPE 74  Natrialba magadii
WP_004041548    3 ETVLLVGGGGREHAIARALAPDc------DLYACAsnRNPGIAALAE-GFETIsetaaeDIVAYAES--VGATLAIVGPE 73  Haloferax volc...

2YYA_A         72 APLVEGIVDEFekRGLKIFGPNKEAAKLE 100 Aquifex aeolicus
18_pfamImport  73 AALEAGVADALdeAGVYTFGPRQDAARIE 101
WP_020447782   77 SALEAGVVDALddAGIYAFGPREAEARIE 105 Salinarchaeum sp. Harcht-Bsk1
WP_015409746   76 SALNAGIADALdeAGIYAFGPRRAEARIE 104 Natronomonas moolapensis
WP_011323693   76 SALNAGVADALdaAGVYAFGPREAEAKIE 104 Natronomonas pharaonis
Q18H71         80 SALEAGVTDALdaAGVYTFGPTAEAARIE 108 Haloquadratum walsbyi DSM 16790
WP_049952563   75 APLDAGVSDALedVGVYAFGPKQADAKIE 103 Halostagnicola larsenii
WP_015300708   75 GPLAEGIVDELeaAGVYAFGPREADARIE 103 Halovivax ruber
WP_004214780   75 APLQAGVADELesAGIYAFGPKEAEARIE 103 Natrialba magadii
WP_004041548   74 SGLAAGVADALdeAGIYTFGPQAAEARIE 102 Haloferax volcanii
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