1DVK


Conserved Protein Domain Family
Prp18
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pfam02840: Prp18 (This model is not part of the current CDD release)
Prp18 domain
The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles.
Links
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Statistics
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PSSM-Id: 515224
Aligned: 80 rows
Threshold Bit Score: 148.022
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DVK_A        38 YIHEILSRWKASLEAY-----------HPE----------------------LFLDTKKALFPLLLQLRRNQLAPDLLIS 84  brewer's yeast
Q6C1J2       147 FLARLLSEWEGTLDKGaaaqasgaaeeVSEaanay-------------krhtIFEETQTSLSSLMVLLRHNGLQDEVLAM 213 Yarrowia lipoly...
P33411       116 YIHEILSRWKASLEAYhp---------------------------------eLFLDTKKALFPLLLQLRRNQLAPDLLIS 162 Saccharomyces c...
XP_001528664 178 YLKNLISEWEKEESNS-----------GDhd--------------------sLLLETKKDIVKLLYKLRANKLSEEMLIS 226
XP_036666881 164 YLKEIIREWDSQHNKS-----------DEda--------------------sLLKETKKGIVNLLYKLRSGKIPTEALVS 212
XP_007375085 138 YIKEMIKSWQDCNEAH-----------PSDqq------------------taLLFETKRDIVPLLYGLRTGELSEDILTS 188
XP_001382798 151 CIKDMIRNWEDSINYSeyqta---------------------------vqkkLLHETKRDIVKLLYKLRSHKLNDDMLTS 203
CCE78815     147 ILKDIVREWESNVQTD-----------TPEpq-------------------rVLYEAKRDLVELLYRLRSNSLKPNMLTS 196
XP_006689203 156 YIKSLVHQWEKATEAL-----------PPDspq-----------------heLLLDTKKNLVPLLYKLRSDGLTDDMVVS 207
Q6BYT3       146 YVKYMVKEWENDVQLK-----------TEGfssirddeeregeeesvarqssMLLDTKKDLVRLLYKLRTQKLTDSMLTS 214 Debaryomyces ha...

1DVK_A        85 LATVLYHLQQpKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQ----G-GrN--AANIMIDERTRLWITSIKR 157 brewer's yeast
Q6C1J2       214 LSKVMYHVQH-EEHHQAYDVYLKLCIGNACWPVGVASIGIHARASQNKTIasarNsK-Q--VAHIVNDD-TRQWLVCIKR 288 Yarrowia lipoly...
P33411       163 LATVLYHLQQpKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQ----GgR-N--AANIMIDERTRLWITSIKR 235 Saccharomyces c...
XP_001528664 227 LATIVYHIQA-SQFNKANESYMKLSIGNICWPIGVANVGIHARSASTRIT----GgK-G--VSNIMINESTRKWILSVKR 298
XP_036666881 213 LSTIIYYLQS-NQFNKANESYMKLSIGNVCWPIGVVNVGIHARSSSSRIT----GsK-N--VSNIMMNELTRKWIISVKR 284
XP_007375085 189 LTTIIYYIQQ-KDYRRANESYMKLSIGNVAWPIGVLNVGIHARSAAERIT----GqK-K--QANIMIDDKTRRWITSIKR 260
XP_001382798 204 LTTIVFYLQS-HDFRRANESYMKLSIGNVAWPIGVQNVGIHARSASSKIA----GaT-K--AANIMVDDKTRRWITAIKR 275
CCE78815     197 LATVLYHVQR-AQFKEANESYLKLSIGNVAWPIGVKSVGIHERSASSKIT----GeS-KdkSANIMLDDKTRRWITAVKR 270
XP_006689203 208 LSTICYYLQH-RQFRPANESYMKLSIGNVAWPIGVLHVGIHARSASSRIT----GeK-S--AANIMIDDKTRRWITAVKR 279
Q6BYT3       215 LCTIMYYLQV-RDYRRANESYMKLSIGNVAWPIGVKGVGIHERSAALKIT----GeN-KqnSANIMLDDKTRRWITAIKR 288 Debaryomyces ha...

1DVK_A       158 LITFEEWY 165 brewer's yeast
Q6C1J2       289 LLTFAEGY 296 Yarrowia lipolytica
P33411       236 LITFEEWY 243 Saccharomyces cerevisiae S288C
XP_001528664 299 LIGFKERM 306
XP_036666881 285 LINFKERR 292
XP_007375085 261 LITAKERI 268
XP_001382798 276 IITATERI 283
CCE78815     271 LITYKEKS 278
XP_006689203 280 LITFSETY 287
Q6BYT3       289 LISFAERK 296 Debaryomyces hansenii
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