1VDX,1IUH,1IUH,1VDX,2D4G,5H7E


Conserved Protein Domain Family
LigT_PEase

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pfam02834: LigT_PEase 
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LigT like Phosphoesterase
Members of this family are bacterial and archaeal RNA ligases that are able to ligate tRNA half molecules containing 2',3'-cyclic phosphate and 5' hydroxyl termini to products containing the 2',5' phosphodiester linkage. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family. The structure of a related protein is known. They belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.
Statistics
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PSSM-Id: 397118
Aligned: 107 rows
Threshold Bit Score: 33.5385
Threshold Setting Gi: 81657242
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VDX_A     7 IDvnesvRDSLVRAQDYIG--SKEAKIKFV---ERENLHITLKFLGEITe--eQAEEIKNILKKIaeKYKKhEVKVKGIG 79  Pyrococcus horikoshii
Q82US8    95 VSqp---cGELTVLVQDLRnqLSAAGVRYDt--VKFVPHVTLVRNAKREpeqkHFPETIPPVA----------WAADRWS 159 Nitrosomonas europaea
1IUH_A    99 LRla-------eGLRAGVEelLGEEAVRIPgwdKPFKPHITLARRKAPa---pRVPPVLFGLE----------WPVEGFA 158 Thermus thermophilus
Q9X2H4    92 LGve--ntDRLMKLYEELRneLSHHGFSFE---EKFVPHITIGRVKYYPd------KWEKLIEDIdfPPIE--VAVDRFK 158 Thermotoga maritima...
Q7UM43    95 VAvd-daTSTLTNLVADLEkrFAAMGYKPEp--RDYRPHLTVGRTRSGTr--rANSDVINRWRKFedDEIG-EFNVREIH 168 Pirellula sp.
Q82GK5    97 LG-------TLRLLAERAEaaAGRAGVPMGe-hRRYRPHLTVARSRDa----vDARPYVEALDTFasRT----WTVGELC 160 Streptomyces avermi...
O34570    96 LEpk-knK-TLDRLREHTKqaVLQAGFQVEk--RPYHPHMTLARKWTGEd--gFPAHVPFESGEVs-------MMAERFS 162 Bacillus subtilis s...
Q45633    97 VKee----aALNELRRDVYeaCLSLGFSLDr--RPFAPHITIARKWQGEa--pFQPEALRSLPAAstV-----FSVPEIV 163 Geobacillus stearot...
BAR74428  97 VSen----qDLFPLQKQVHaiCEGNGFSLEt--RPYHPHITVARKWVGEe--kFNLEHIKEVPEIs-------FQADTIT 161 Bacillus anthracis
5H7E_A    94 VKte---aEGLTELAENLRagIRELGIGTDd--LAFKAHITLARKKGPa---pRLPPLIFDQS----------WTAPGLT 155 Deinococcus radiodu...
1VDX_A    80 VFPNPN-YIRVIW 91  Pyrococcus horikoshii
Q82US8   160 LVQSRPtPYGSAY 172 Nitrosomonas europaea
1IUH_A   159 LVRSELkPKGPVY 171 Thermus thermophilus
Q9X2H4   159 IYSSTLtPTGPIY 171 Thermotoga maritima MSB8
Q7UM43   169 VVGSFLeKHGPTY 181 Pirellula sp.
Q82GK5   161 LVRSRLpKSGVPG 173 Streptomyces avermitilis
O34570   163 LFQIHL-NQSPKY 174 Bacillus subtilis subsp. subtilis str. 168
Q45633   164 LYRTNM-EKTPKY 175 Geobacillus stearothermophilus
BAR74428 162 LYESHV-KETPKY 173 Bacillus anthracis
5H7E_A   156 LYRSILrKTGPIY 168 Deinococcus radiodurans
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