8FO6,1IAJ,4NL0


Conserved Protein Domain Family
Alpha_kinase

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pfam02816: Alpha_kinase (This model is not part of the current CDD release)
Alpha-kinase family
This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.
Statistics
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PSSM-Id: 515205
Aligned: 159 rows
Threshold Bit Score: 84.2578
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8FO6_A         70 GRGAMRECFRtk-klSnflhaqQWKGASNYVAKRYIEP---V-------------DRDV--YFEDVRLQMEAKLWGEEY- 129  human
XP_001569097  881 GQGGMRVCFEitevdP------VACKEVVMVAKMYRRTiknVv------------EKD---YFTSVTVQKLSALFAKEF- 938 
XP_001569098    2 GHGGMRVCYEve-dvD------EEGAGTPMVAKMFRRNisdVv------------EKD---YFNEGKAQCMCEEFANNF- 58  
Q584K8         50 AKGGMRVCYEve-eiE------DDGSRTRCIAKLFLKVvsdVk------------EED---YFCEGEAQCLCEEFASNF- 106  Trypanosoma b...
XP_001469852   80 SQGTMRVCFAle-elD------ETGFSSRMVAKMFRHNiskVv------------ESD---YFNEGEAQCICGIFAEKF- 136 
Q4Q0V9        165 HQDKYFATFAve-llD------LVKPATPMLAKVYRHNidlVs------------ETD---YYSLGQAQALCEEFARDYt 222  Leishmania major
XP_001884175  366 ARGAMKLAFD-----L------HLEDGSQLVAKRFFRVtssDmdddqlgavdpdvQKEA--IENEAHRLAEGQWFLKEFy 432 
XP_001887139  368 ASGATKHVYQl------------TMDSELFVAKKFFEIgsdDsvt-------adeNAEF--LKCELIRLKTATWFLRKF- 425 
XP_001829478  388 ASGTMKVVFDa----S------IPDYDSPLIVKRFFKIdnlSspeldksgtppkaEFDVltHNSLIRAEGVRAGLGQRLl 457 
XP_001569097  159 HQDNYFATFAie-llD------TAKPAVPMFARVYRHNidgVv------------ETD---YYSLGQAQALCEEFARDYt 216 
8FO6_A        130 N------RHKPPkqVDIMQMCIIel-------------kdRPGKP---------------LFHLEHYI-E-GK----YIK 169  human
XP_001569097  939 Nre---rKEGAPlrLNVLEGAVValdra--------vlspELLAKrtgffsyrtedtkraMFCMETKL-A-GP----FTK 1001
XP_001569098   59 Nrih-ltNVNKPn-ISFLQCYVVriprk--------sipdAYQNKrtgffsyktqdthevMFVMEPML-S-GR----FTK 122 
Q584K8        107 Nka--pfHGPNKprISFLQCQVLrisrn--------iiprEYRRLkdgffshrtvdtgdvLFVMEPKL-G-GH----FTK 170  Trypanosoma b...
XP_001469852  137 Nrvq-vpAGFQRhiVSFLQCETVrikls--------evpeAYQHKrsgffsyrttdsadiLFTMEPRL-A-GN----FTK 201 
Q4Q0V9        223 rt--aarSHYVKfhLPLLTNRVVvrldmd------svldpAIRTArkgffsyrtqdtrqvMFLMEPNTvAcEAlgisFAS 294  Leishmania major
XP_001884175  433 TlcstqaKVSVDkaIQFSSAFVGee-------------tdSSESSfasglregpsslnkvYWLVEPKR-P-ST----VTK 493 
XP_001887139  426 KaaakemKVDIAtnIILSEGFLAr----------------EVGTPseasglgpleegssaVWLVEPHR-T-KT----VLK 483 
XP_001829478  458 Nsf---yRDAEQadVNVYKYFFFeiptfyqeiskpspasgVVSDElfgvpseseveenliLWCGERKH-PsEV----VIR 529 
XP_001569097  217 rt--darHGYLKfhLPLLTNRVVvrldlh------svldpAIRRSrrgffsyrtqdtrqiLFLMEPNTiAcETlgvsFAS 288 
8FO6_A        170 YNSNSGFVrd-------------dN--IRLtpQAFSHFTFERSGHQLIVVDIQG----V---G-----DLYTDPQIHTet 222  human
XP_001569097 1002 YSGNMGEAyptnecrl-slsaareRtmIFEtvEALSHYSLERSGGGLLVCDMQG----V---K-----NDLTDLEVHTyd 1068
XP_001569098  123 YNSNYGEIyredkkaalssteakrRtqIFEaaEAFSHFTLVESGGSMLVCDLQG----V---N-----DFLTDPQIHTed 190 
Q584K8        171 YNSNYGDVyeddkhck-tdsqkrkRqhMLHvaEAFSHFTLVDSVGSMLLCDLQG----V---N-----DLLTDPQIHTed 237  Trypanosoma b...
XP_001469852  202 YTNNFGDVydgferrq-sleeekkRhrVLMavEAFSHFTLVESGGSMLVCDLQG----V---N-----DFLTDPQIHTed 268 
Q4Q0V9        295 REVDEGKCysrgd-------amwsRdiYRDiaDGFSHFTYVRSRMCMVAHGFMR----S---N-----GYLLDPLFHTtd 355  Leishmania major
XP_001884175  494 FSGTLSHQmn-------------rKdlQSLtiAAFAHFVYLKSKATRVFADIQGtttnVkgk----dtMVLFDVMTHSpa 556 
XP_001887139  484 FSGTLNHPn--------------rQdkVGTtiSSFAHFSYQVSNRELVFADIQGspmnIqgr----dtIVLFDIMSHSpt 545 
XP_001829478  530 FNGTLSHPst-------------rTdmKHLtmYAFCHYVYGVTKGTLVFADIQGtpatLtqgNqdkdgYLLFDVMTHTeh 596 
XP_001569097  289 LEVEKGKRyergd-------stwlRdiYSDiaEGFSHFTYVKSRGCMVAHGLVR----S---N-----GYLLDPLFHTtd 349 
8FO6_A        223 g--tdfGDGNLGVRGMALfFYSHACNRIC 249  human
XP_001569097 1069 g--qglGVGNLGARGIQKfAVGHRCTSVC 1095
XP_001569098  191 g--kglGMGNMGQEGIDKwIEKHDCNDIC 217 
Q584K8        238 g--rglGLGNMGVEGITKfVVNHKCNEIC 264  Trypanosoma brucei
XP_001469852  269 g--kglGMGNMGQDGIRKwMEAHVCNEVC 295 
Q4Q0V9        356 s--erfTMGDAGRSAMEDwVEGHRCGDTC 382  Leishmania major
XP_001884175  557 g---dtGIGDFGPDGIASfLDDHRCGSIC 582 
XP_001887139  546 t---dsGIGDHGPDGIESfISQHCCNHMC 571 
XP_001829478  597 k---asGIGDFGQEGINRfVEEHVCQEVC 622 
XP_001569097  350 rerfrmGDG--GRRAMSKwFERHQCSDTC 376 
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