1WPK


Conserved Protein Domain Family
Ada_Zn_binding
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pfam02805: Ada_Zn_binding (This model is not part of the current CDD release)
Metal binding domain of Ada
The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site. One of these cysteines is a methyl group acceptor. The methylated domain can then specifically bind to the ada box on a DNA duplex.
Links
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Statistics
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PSSM-Id: 515196
Aligned: 219 rows
Threshold Bit Score: 57.47
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WPK_A        11 QRWQSVLARDPNADgeFVFAVRTTGIFXRPSCRARHAL---RENVSFYANASEALAAGFRPCKRC 72  Escherichia coli
XP_002615123   8 lRWKAYQFSDPFASgsFLVCNAKSKVFCRPDCDAH-PIaeqQHEVKFVDSVADATELGFSPCDSC 71 
XP_001485842   8 AKWKAYQFGDPFATgaFYVCNKVAKVFCRPDCDAR-PVtnlKLEIKFVDTPHDAIANGYVACAHC 71 
EMG51013       8 SKWKAYQLNDPFATgsFFVCNKISQIFCRPDCDAH-PTtnlKSEIKFVDTYNDAINSNFKPCESC 71 
XP_006684092   8 SKWKAYQFSDPFATnsFLVCNKTNKIFCRPDCDSV-AKtdlKSDIKFVDFYEDAIKSGYKPCKFC 71 
CCE84493       8 AKWKAYQFSDPFATgsFCVCNKINKTFCRPDCDAR-PItnlKSEIKFVKSAEEGMNFGYTPCEHC 71 
EDK43097       8 AKWKAYQFSDPFAAgsFFVCNKLNRFFCRPDCDAR-PRtnlKSEIKFVPTAQEAMAIGFIPCESC 71 
Q6BM08         8 tKWKAYQFSDPFAAksFFVCNKINKFFCRPDCDAR-PItnlKSEIKFVNLVSDAINYGYVACNSC 71  Debaryomyces hansenii
XP_002546897   8 SKWKAYQFNDPFAAgsFFVCNKINQIFCRPDCDVR-PItnlKSEIKFVSNSKQALQLGYKPCEHC 71 
XP_002493009   8 SRWNAYQFNDPFAAdkFFVCSRRTNTCCRPNCGLGFNHsneKSDVSFVDTIEEAEQLGFSKCRFC 72
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