5DQS,4XT0,1K0D,1NHY,1C72,3GTU,1GUH,1ML6,1VF2,1BYE


Conserved Protein Domain Family
GST_N

?
pfam02798: GST_N 
Click on image for an interactive view with Cn3D
Glutathione S-transferase, N-terminal domain
Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognized); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognized). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.
Statistics
?
PSSM-Id: 397090
Aligned: 23 rows
Threshold Bit Score: 61.929
Threshold Setting Gi: 122113188
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5DQS_A   4 AAGTLYTYPENWRAFKALIAAQ--YSGAQVRVlsAPPHFHFGQTNRtPEFLRKFPA-----GKVPAFEGDdGFCVFESNA 76  human
Q4D347   1 MSLTLWSGVNPEN-ARTHKLLAa-AALANVAV--TLKACEYGRENEtAEYCRNCSPc----GRYPVLQTE-EGCVFESNA 71  Trypanosoma cruzi
1C72_C   2 VTLGYWDIRG--LAHAIRLLLE--YTETPYQE--RRYKAGPAPDFDpSDWTNEKEKlgldfPNLPYLIDG-DVKLTQSNA 74  chicken
P08010   3 MTLGYWDIRG--LAHAIRLFLE--YTDTSYED--KKYSMGDAPDYDrSQWLSEKFKlgldfPNLPYLIDG-SHKITQSNA 75  Norway rat
3GTU_B   6 MVLGYWDIRG--LAHAIRLLLE--FTDTSYEE--KRYTCGEAPDYDrSQWLDVKFKldldfPNLPYLLDG-KNKITQSNA 78  human
1GUH_C   4 PKLHYFNARG--RMESTRWLLA--AAGVEFEE--KFIKS------A-EDLDKLRNDgylmfQQVPMVEID-GMKLVQTRA 69  human
1ML6_A   4 PVLHYFNARG--RMECIRWLLA--AAGVEFEE--KFIQS---PEDL-EKLKKDGNLm---fDQVPMVEID-GMKLVQTRA 69  house mouse
1BYE_B   1 APMKLYGAVMSWNLTRCATALE--EAGSDYEI--VPINFATAEHKS-PEHLVRNPF-----GQVPALQDG-DLYLFESRA 69  Zea mays
P30110   2 SPVKVFGHPM--LTNVARVLLFleEVGAEYEL--VPMDFVAGEHKR-PQHVQLNPF-----AKMPGFQDG-DLVLFESRA 70  bread wheat
P04907   2 APLKLYGMPL--SPNVVRVATVlnEKGLDFEI--VPVDLTTGAHKQ-PDFLALNPF-----GQIPALVDG-DEVLFESRA 70  Zea mays
5DQS_A  77 IAYYVS 82  human
Q4D347  72 ILRHIA 77  Trypanosoma cruzi
1C72_C  75 ILRYIA 80  chicken
P08010  76 ILRYLG 81  Norway rat
3GTU_B  79 ILRYIA 84  human
1GUH_C  70 ILNYIA 75  human
1ML6_A  70 ILNYIA 75  house mouse
1BYE_B  70 ICKYAA 75  Zea mays
P30110  71 IAKYIL 76  bread wheat
P04907  71 INRYIA 76  Zea mays
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap