Conserved Protein Domain Family
HlyC

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pfam02794: HlyC 
RTX toxin acyltransferase family
Members of this family are enzymes EC:2.3.1.-. involved in fatty acylation of the protoxins (HlyA) at lysine residues, thereby converting them to the active toxin. Acyl-acyl carrier protein (ACP) is the essential acyl donor. This family show a number of conserved residues that are possible candidates for participation in acyl transfer. Site-directed mutagenesis of the single conserved histidine residue in Escherichia coli HlyC resulted in complete inactivation of the enzyme.
Statistics
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PSSM-Id: 397087
Aligned: 18 rows
Threshold Bit Score: 145.117
Threshold Setting Gi: 81634861
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012288175   26 AIGQIVWLLSQSAVHR-ELKIKALEWSFMPAVVSEQFRIFrfgptpglsdadpasfaqfgltRegLETLPLGVAIWANLS 104 Caulobacter sp...
P74650         17 ILGEIVFLMGASQNFA-KYPVSFIINYLLPSIYLNQYRIY----------------------RtvKDNKPIGFACWAFIN 73  Synechocystis ...
WP_015219340   15 ILGEIVFLMGSCDNSR-KYPISFIINYLLPSIHLNQYRLY----------------------RtvKENKPIGFACWAFVS 71  Cyanobacterium...
Q65TD5         24 LFGAFATIWLRSEYHS-KAPLYRFAERILPVLRNKQFALF----------------------I--KDNEPVAYFSWAYFT 78  [Mannheimia] s...
Q9JZB0         24 AFGALVWLWAVSPIYQ-HAGVQEAAVNILPVLKNGQFALF----------------------S--SNGHPVAYCTWAYFD 78  Neisseria meni...
jgi:Galf_1447  40 ILGPVLWLYARDPLKK-FTFIADLDWALLPAVILDQCRLY----------------------T--KNNIPFAFFTWAKVN 94  Gallionella ca...
WP_013135297   22 VLGEAVLVLLNSPAHRlSFFVGDLEWLLIPAISKEQFRLY----------------------Rd-KENKPVGLILWAFVD 78  Arcobacter nit...
WP_013041271   19 IFGEIVWLLSQSPRHA-DVTAVEMNWLLMPPILRRQFHIF----------------------Q--EGERPIGAAIWAMLD 73  Sphingobium ja...
Q7MDK4         24 MIGGVMLLSQHSPLHR-RYVVAEWQQRILPAFELNQFCYY----------------------Ed-EHGRPIAFCNWAFVS 79  Vibrio vulnifi...
WP_011705265   14 MLGGVMLLSQHSSLHR-RYSVAEWQQRILPAFELNQFCYY----------------------Ed-SCGRPVAFCNWAFVS 69  Aeromonas hydr...
WP_012288175  105 EAAEAKLEAGE-HLAA---E-DWASGDRTWLVELISPFATPDNklsqiMLLDLINGPF---KGRAFHLHR--TDPQTGKR 174 Caulobacter sp...
P74650         74 DQVEKELIENDiNLSV---E-ERNSGENIYVLYFIAPFGHAKQ-----IVHDLKNNIF---PNKIVKGLR--LDKDGKKV 139 Synechocystis ...
WP_015219340   72 DQVEEQMIKNDiNLTI---E-ERKSGENLYILYFIAPFGHAKK-----ISQDLKNNIF---PYRMIKGLR--LTKDSKKI 137 Cyanobacterium...
Q65TD5         79 QEAEEAYLHNDdVLLE---AgNWCAGNNLWIIDWFAPANLTKE-----IKPLIERHLF---PNEILTALY---HKSAVNH 144 [Mannheimia] s...
Q9JZB0         79 EETEWQYLQSNdVLRH---SeNWCSGNRMWLINWFAPFGDSRM-----MKRILVH-LF---PKREIRWLY---HRGSEKG 143 Neisseria meni...
jgi:Galf_1447  95 DEIDQRLRSGVlRIAP---H-EWQSGEHVWLIDAVAPFGQIEK-----MLEELRKEQL---AGQKISALL--PDPLNANQ 160 Gallionella ca...
WP_013135297   79 NEVDKKLEMGIgKLGF---N-DWTSGENLWVIDLIAPMGGGDK-----MLGELKDTVF---KGKTFKYQS--VDKEGNRK 144 Arcobacter nit...
WP_013041271   74 EAGEQKVMKGLrETGAkleDaEWTAGDRLWLVELIAPFATVENrhaelMMADLITGPF---SKRAFKMLS--TNPNSGES 148 Sphingobium ja...
Q7MDK4         80 EQIRDELLSGVrEISP---S-DWRSGQHIYIPEMIAPFGHGRE-----VVNDLRRRVFlpwKGQKVCTVRgkVDAQNDRC 150 Vibrio vulnifi...
WP_011705265   70 LSIRDTLLAAErELIR---E-DWQSGDHIFIPEMIAPYGHARA-----VVSDLRRRIFlpwKGQRVCTVRghVHAELGHC 140 Aeromonas hydr...
WP_012288175  175 EKVT 178 Caulobacter sp. K31
P74650        140 LRVA 143 Synechocystis sp. PCC 6803 substr. Kazusa
WP_015219340  138 AKIA 141 Cyanobacterium aponinum
Q65TD5        145 VQKR 148 [Mannheimia] succiniciproducens MBEL55E
Q9JZB0        144 KRIM 147 Neisseria meningitidis serogroup B
jgi:Galf_1447 161 LKLH 164 Gallionella capsiferriformans ES-2
WP_013135297  145 IVVd 148 Arcobacter nitrofigilis
WP_013041271  149 QVVs 152 Sphingobium japonicum
Q7MDK4        151 IRKI 154 Vibrio vulnificus YJ016
WP_011705265  141 VRRV 144 Aeromonas hydrophila
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