Conserved Protein Domain Family
DDT
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pfam02791: DDT (This model is not part of the current CDD release)
DDT domain
The DDT domain is named after (DNA binding homeobox and Different Transcription factors) and is approximately 60 residues in length . Along with the WHIM motifs, it comprises an entirely alpha helical module found in diverse eukaryotic chromatin proteins. Based on the structure of Ioc3, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes. In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket.
Links
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Statistics
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PSSM-Id: 515186
Aligned: 131 rows
Threshold Bit Score: 37.4984
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002287018  420 HCVPDMLMVWDFLCTFCRTLSL-------EPIELDDFASALS--FQpesreensqstDemgqssssssvpvyLSESHIAL 490 
XP_040048487 1574 KAFAHCLAVVEFLHGYGKIIGLnipkdvpS---LATLQEGLLglGdgq----------------------geVQDLLIKL 1628
EDO44815       63 KAFADLLMVEEFVHNFGGALDIdpaaempS---ISDMQLSMLcqGEd------------------------vLLPLCQLL 115 
XP_015790700  743 KVFADCLMFFEFLNNFGETLGFdme-slpS---LNTLQKALLnlDEsae---------------------keLVSTLHQL 797 
XP_002425532  692 QAFADTLMVFEFLHNFGETLGFdmd-slpT---LSNLQGALLndEene----------------------eeLLSIMTHL 745 
3_pfamImport    1 KAFADILMVFEFLHNFGETLGFdm----eSLPTLDSLQQALMpnEHsse-----aeeE--------------LFSVMTHL 57  
XP_046439020 1056 QALADILMLYEFLHTFGETLGFdme-slpS---LDSLQRALLydSeae----------------------eeLLSVMTHL 1109
EDW47427      383 QAMADLLMVFEFLHNFGETLGFdme-slpS---LQNLHDALMsdSNada--------------------eeeLLSVMTHL 438 
XP_029689731 1413 AAFSHCLAVVEFLHAYGKLIGLdipkdipS---LATLQEGLLglAesq----------------------gaVQDLLMKL 1467 torafugu
XP_018668490 1022 kATADVLMVLEFLHTFKDAILIdes-vipT---FEQLQRSLLndPeht----------------------gsLVQLTMAL 1075 vase tunicate

XP_002287018  491 LRLLLQD 497 
XP_040048487 1629 MEAALLD 1635
EDO44815      116 LTQAMAD 122 
XP_015790700  798 LVCAIDD 804 
XP_002425532  746 LVCAIED 752 
3_pfamImport   58 LVCAIED 64  
XP_046439020 1110 LVCSIED 1116
EDW47427      439 LVCAIED 445 
XP_029689731 1468 VEAALHD 1474 torafugu
XP_018668490 1076 LHQCLCD 1082 vase tunicate
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