1MNG,6BEJ,5X2J,3TJT,1ISA,8SKS,3TQJ,3H1S,1MY6,3ESF,1QNN,2GPC,2AWP,1MA1,3DC6,3LIO,1XRE,3RN4,1AR4,3AK1,4C7U,8RAS,1KKC,3EVK,1GN3,4FFK,1B06,7SBH,1COJ,8BHX


Conserved Protein Domain Family
Sod_Fe_C
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pfam02777: Sod_Fe_C (This model is not part of the current CDD release)
Iron/manganese superoxide dismutases, C-terminal domain
superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.
Links
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Statistics
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PSSM-Id: 515174
Aligned: 758 rows
Threshold Bit Score: 84.8141
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1MNG_A         98 PVG-ELKKAIDEQFGGFQALKEKLTQAAMGRFGSGWAWLVKDpFGKLHVLSTPNQDNPVMEgfT--PIVGIDVWEHAYYL 174 Thermus thermo...
CCZ05071       99 PED-EILYAIKYNFGSYTNFVDWFTKKANSLIGSGYVWLVYRdY-KLDIVCGANQNTPLSYpaT--PILNIDIWEHAYYL 174
85_pfamImport   1 ERG-ALHRKMSESFTSFENFKNEFTDAAMSVFGSGYAWLVYDgK-KLKITTTKNQDTPLCRgfI--PILNIDVWEHAYYL 76 
WP_022515303  100 PIPdPLSAFLIESFQSPEKFKEKFKAATLSVFGSGYAWLTIEpTGRLCIFVTKNQDTPLPAglF--PLLNIDVWEHAYYL 177 Roseburia yibonii
CDA78699      100 PVPeDVMEKIEQNFGSLESFYEQFKQSALSVFGSGYTWLVLEn-GNLKILTTANQNTPDLLkqY--PVLNLDVWEHAYYL 176
WP_012198235  113 VTGnDFLNLINQTFGNFNEFKAKMKEAALQVFGSGYAWLVSNsRGELSIVTTANQDTPLTLglI--PLLPIDVWEHAYYL 190 Lachnoclostrid...
WP_013657599  183 PTG-QLKTAIETQFGTFDNFKAALTLAALSVFGSGYAWLILNpYGRLQIVTTGNQTTPIPLrgI--PLLPIDVWEHAYYL 259 Cellulosilytic...
CCY58127      101 PEG-TLATAIQRDFDSLDNFQRMLTNAAVRQFGSGYAWLVVEnE-KLSVVSTDNQNTPITEtqK--PILCIDVWEHAYYL 176
WP_015393942   97 PEG-ILLDAINSAFGDLEKLKSEVSNAAVSQFGSGYGWLVKDeDGKLSVKKTLNQNSPLIE--GliPILTIDVWEHAYYL 173 Clostridium sa...
WP_022746353   98 PEG-KLLKEINKAFGTLDNLKEEINNVSINQFGSGYGWLVRDkHGKLKVLNTLNQNTPLSC--GftPILTIDIWEHAYYL 174 Clostridium sa...

1MNG_A        175 KYQNRRADYLQAIWNVLNWDVAEE 198 Thermus thermophilus
CCZ05071      175 QYKNERANYITNWFNVINWEYVNK 198
85_pfamImport  77 KHYNDRKAYIEDFVKAVNWAMAEK 100
WP_022515303  178 KHYNERAAYIDDWFHIADFARANE 201 Roseburia yibonii
CDA78699      177 KYYNLRVDYIDNWFSLIDWKRVQT 200
WP_012198235  191 DYQNRRNDYIDEWFDLINWDFVYY 214 Lachnoclostridium phytofermentans
WP_013657599  260 KHQNKRGNYISDFFNVINWDRLGE 283 Cellulosilyticum lentocellum
CCY58127      177 QYQNRRADYVSNWFGLINWPYVQS 200
WP_015393942  174 KYKNLRPDYVKNIWNIIDWKKIEE 197 Clostridium saccharoperbutylacetonicum
WP_022746353  175 KYKNLRAEYVKNIWNIINWEKVEE 198 Clostridium saccharobutylicum
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