1QZH,1PH7


Conserved Protein Domain Family
POT1

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pfam02765: POT1 
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Telomeric single stranded DNA binding POT1/CDC13
This domain binds single stranded telomeric DNA and adopts an OB fold. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms.
Statistics
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PSSM-Id: 397060
Aligned: 47 rows
Threshold Bit Score: 53.8998
Threshold Setting Gi: 549066
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1QZH_F        29 FQSIRSSQelqKKNTIVNLFGIVKDFTPSRQslHGTKDWVTTVYLWDPT------------------CDTSSIGLQIHLF 90  fission yeast
Q330J1       314 DRSVEKA----ALKQDVSLSAVVLTEIDKKHanLPVHSLQDLFHNIDNDk-----------------EISGKDTLRTQFF 372 Paraurostyla we...
Q2Q1P7       299 EKQPDKA----SLKKGVNMQAVVLTEIDKKHanLPNTPLSELFHHADTDp-----------------ELQNKNTFRTTFQ 357 Urostyla grandis
1PH7_A       283 SVEVA------SLKKNVSLNAVVLTEVDKKHaaLPSTSLQDLFHHADSDk-----------------ELQAQDTFRTQFY 339 Sterkiella nova
Q330J0       307 DKALEKA----ALRQDVSLSAVVLTEVDKKHaaLPTHSLQDLFHNVDTDr-----------------ELAGKDTFRTQFY 365 Uroleptus sp. W...
P29550       313 dkSVEKA----ALKQDVSLSAVVLTEVDKKHagLPTHSLQDLFHNADTDk-----------------EISSKDTFRTQFY 371 Stylonychia myt...
O76380       316 drAVEKA----ALKQDVSLSAVVLTEVDKKHagLPAHSLHDLFHNADSDk-----------------ELSSKDTFRTQFY 374 Sterkiella hist...
Q6CJ70       527 VSNIVPS----ASSRYYTVIGLAVTVKY-----TGGKTLVLSFTDFTANpkvnygyd--sflgsfqeRIPENEHVHALIY 595 Kluyveromyces l...
XP_001642283 411 FKDLVLNE---SEIKYVTMMGLLVSCSFEHK--SFAKLIFTDFTKNNVTqnflfdr----flidynnKIDIDEGFRVVMY 481 Vanderwaltozyma...
Q75E25       511 ALSIDQLS---ATTSSATIFAMLICAR------VDPGSKVHHFSFTDFTenllisckldpylndycnRLKATECIYVKSY 581 Eremothecium go...
1QZH_F        91 SKQGNDLPVIKQVGQPLLLHQITLRSYRDRTQGLSKDQFRYAl------WPDFSSNSK---DTLCPQPMPRLMKTGDKEE 161 fission yeast
Q330J1       373 VSKIEP-SDVKEWVKAYDRKTKKATSLKGAAAAKGGENIFQVqflakdaSTQLNSNTYrilLYTHEGLGAGFFGAVKPDN 451 Paraurostyla we...
Q2Q1P7       358 VIKIEP-SDVKEWAKSYDKKTKQASSLKG---GKGANPIFQVqflvkdaSTQVNNHTYrilLYTHDGLGANFFGINADNL 433 Urostyla grandis
1PH7_A       340 VTKIEP-SDVKEWVKGYDRKTKKSSSLKGAS-GKGDNIFQVQflv-kdaSTQLNNNTYrvlLYTQDGLGANFFNVKADNL 416 Sterkiella nova
Q330J0       366 VTKVEP-SDVKEWVKSYDKKTKKSASIKGAAAKGDNLIYQVQllv-kdaSTQLNNNTYrvlLYTHDGLGANFFPVKADNL 443 Uroleptus sp. W...
P29550       372 ITRVEPVDVK-EWVKSYDRKTKKPSSHKGAGAKGGENIFQVQflv-kdaSTQLNNNTYrvlLYTQDGLGANFFNVKPDNL 449 Stylonychia myt...
O76380       375 VTKIEP-SDVKEWVKAYDRKTKKVTSLKGSAAKGGDNIFQVSflv-kdaSTQLNNNTYrvlLYTHDGLGANFFNGVKADN 452 Sterkiella hist...
Q6CJ70       596 LNRVESLNE--KLQSIIKMGLMECADKGNSNITHRSIIFKFTv-----kCQLFQGKLNtviLDADPITPTTPV--TTEEY 666 Kluyveromyces l...
XP_001642283 482 LNQFEKFEK--SIIEAYGYEIKKMFINDNENLTHKGIICKLSl-----kVKMFNGKLNailRECSLIRNEGIQNLKIDEK 554 Vanderwaltozyma...
Q75E25       582 PEYIHNLDAY----TLRHYNRRLVDCHNGRDTNLTNFGMVFRlk---ldVKSYQQRINgiiREAVLITGDTRF--TGDEE 652 Eremothecium go...
1QZH_F       162 QFaLLLNKIWDE 173 fission yeast
Q330J1       452 LYkNNEARKKLE 463 Paraurostyla weissei
Q2Q1P7       434 HK-NDGARKKLE 444 Urostyla grandis
1PH7_A       417 HK-NADARKKLE 427 Sterkiella nova
Q330J0       444 YK-NNDARKKLE 454 Uroleptus sp. WJC-2003
P29550       450 YK-NNDARKKLE 460 Stylonychia mytilus
O76380       453 LHkNADARKKLE 464 Sterkiella histriomuscorum
Q6CJ70       667 KL-LKPLRNKIF 677 Kluyveromyces lactis
XP_001642283 555 LQ-LESIHKQIL 565 Vanderwaltozyma polyspora DSM 70294
Q75E25       653 RL-LEAFYNRAF 663 Eremothecium gossypii
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