7SIY,6BK5


Conserved Protein Domain Family
Cbl_N3
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pfam02762: Cbl_N3 
CBL proto-oncogene N-terminus, SH2-like domain
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.
Links
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Statistics
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PSSM-Id: 485958
Aligned: 12 rows
Threshold Bit Score: 170.277
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7SIY_A       217 THPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPD 294 human
XP_001745549 228 RHPAYQAFITYDEVEATLSNHRHK--PGSYVFRLSCTRLGQWAIGFVAKDGQIVQTIPQSKSLYQALIDGAEQGTFLYPN 305
XP_004989936 245 NHPAYKAFITYDEVEAILRHHLHR--PGSYVYRLSCTRLGQWAIGFVTRAGKIVQTIPQNKSLYQALLDGVEERLYLYPD 322
XP_002112227 260 SHPGYAAFLTYDDAKNALEPFLDR--PGSYIFRLSCTRLGQWAIAYVEESRNVVQTIPNNKPLRQALIDGFNDGIYLYPA 337
XP_004364071 283 THPAYQAYMTYDEVNTVLKPFVNK--PGSYVFRLSCTRLGQWAIGYVNAEKKVVQTIPNTKSLYQALIDGSVDGTFKYPM 360
XP_009026767 104 SHPGYVAFMTYDEVKAMLAKFKDK--PG------SCTRLGQWAIGYVTKNNEILQTIPQNKSLGQALIDGQKEKYYLYPA 175
KAF8355552   256 DHKGFVAFLTYDEVRKRLDRFINK--PGSYVFRMSCTRLGQWAIGYVAPDGKIYQTIPQNKSLIQALHEGGREGFYLWPD 333
Q6ABG8       256 AHPGYCAFLTYDEVKKRLEKLTKK--PGSYIFRLSCTRPGQWAIGYVAPDGKIYQTIPQNKSLIQALHEGHKEGFYIYPN 333 Caenorhabditis ...
XP_012400422 159 THPGYMAFLTYDEVKARLQKFIHK--PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPD 236
XP_018655197 215 LHPGYMAFMTYDQVKGVLKRYCTHpgPGTYIFRLSCTKLGQWAIGYITQELKIVQTIIQNKSLAQALVDGEREGFYLYPN 294
6BK5_A       245 NHPAYKAFITYDEVEAILRHHLHR--PGSYVYRLSCTRLGQWAIGFVTRAGKIVQTIPQNKSLYQALLDGVEERLYLYPD 322 Salpingoeca ros...
XP_068070093 246 THPGYMAFLTYDQVKARLEHYRHR--PGSYIFRLSCTQMGQWAIGHVTSDGSIVQTIPQNTPLYQALIQGFREGCYLYPD 323 zebrafish

7SIY_A       295 GRNQNPDL 302 human
XP_001745549 306 GEDANPDI 313
XP_004989936 323 GKNVQLDL 330
XP_002112227 338 GNDANPDL 345
XP_004364071 361 GQDDNPDI 368
XP_009026767 176 GQAHNPNI 183
KAF8355552   334 GNDKDMDL 341
Q6ABG8       334 GRDQDINL 341 Caenorhabditis elegans
XP_012400422 237 GRNQNPDL 244
XP_018655197 295 GKPSPTTL 302
6BK5_A       323 GKNVQLDL 330 Salpingoeca rosetta
XP_068070093 324 GRDVNPDL 331 zebrafish
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