2DWG,8JC5


Conserved Protein Domain Family
RUN

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pfam02759: RUN (This model is not part of the current CDD release)
RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
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PSSM-Id: 515160
Aligned: 36 rows
Threshold Bit Score: 99.2595
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DWG_A         46 QFFVVMEHCLKHGLKA---------------------------------------------------------------- 61   house mouse
Q94222        607 RLANSFRQIMDHGIREnalytsma-------------------------------------------------------- 630  Caenorhabditi...
Q17FM5        615 TLAPTIKQVLEHGMKRpsflggpc-------------------------------------------------------- 638  yellow fever ...
KAI2597964      8 TLCPALKALFEHGLKKpsllggac-------------------------------------------------------- 31  
Q96C34        429 ELTVAVRDLLAHGLYAsspgmslvmapiacll------------------------------------------------ 460  human
Q9W5C1        516 NFARTLQQLIQHGLRIpaesaasslmvpfmrclhpgppvv---------------------------------------- 555  fruit fly
Q17Q22        446 QLAKTIQGLMQHGLRGitessgslvpfisgcfsgggyhsqgpsknsaeerfyrgdsrrkstggmtka------attppkr 519  yellow fever ...
Q7QH55        369 RLAKTIQRLMQHGLRSisesashslvpfisgcfsttgsghsgtnhssmsgranesfyrsevrrkstgatttapkkqssyv 448  Anopheles gam...
XP_003965057  382 elalalkellaHGLFCpsqtmslvlapiscll------------------------------------------------ 413  torafugu
XP_011604172 1147 sLCPALHSLLTDGLKPhq-------------------------------------------------------------- 1164 torafugu
2DWG_A         62 --------------------------------------------K-KTFLGQNKSFWGPLELVekl------------vp 84   house mouse
Q94222        631 ------------------------------------yhpwsfieD-IAYYSVEKNFNSVYSRLtlcntfnl-dedgkilt 672  Caenorhabditi...
Q17FM5        639 -------------------------------------hpwlfieE-AATREVEKDFESVYSRLvlcktyrl-dedgkvlt 679  yellow fever ...
KAI2597964     32 -------------------------------------hpwlfieE-AAGREVERDFASVYSRLvlcktfrl-dedgkvlt 72  
Q96C34        461 ----------------------------pafssapeamhpwelfVkYYHAKNGRAYVESPARKlsqsfalp-vtggtvvt 511  human
Q9W5C1        556 --------------------ppavggdsqflglgramhawelvlA-YYRLKHGEEYNNTPARKlsqsfqld-ivdaqavt 613  fruit fly
Q17Q22        520 nsssleeeepiemnlftqleededeeveycdgdesemhawelllL-YYNIKNGDRYNSAPARKlsesfnld-lvegrpqs 597  yellow fever ...
Q7QH55        449 eedtsnaavteenlfsqldddeeedmepqfdsnnkdemhvwellLvYYNIKNGDRYNSTPARKlsesfnld-ivdgrpls 527  Anopheles gam...
XP_003965057  414 ----------------------------phhpaphtmhpwdlfvK-YYHSKNGKAFVESPARQlsqsfslpvgggpvtvt 464  torafugu
XP_011604172 1165 -------------------------------------------sD-LIAGRRPNSAWGLIQAStrp------------gq 1188 torafugu
2DWG_A         85 EAAEI---TASVKDLPGLKTp-----VGRGRAWLRLALMQKKLSEYMKALINKKE---LLSE-FYEVNALMMEEEGA--- 149  house mouse
Q94222        673 PEELL---FRSVQLINDSHNavsahsDVKLRSLLVVGVNEQCIHLWFDLLCSATQhehIRNK-YYHSWAFIRSPAWR--- 745  Caenorhabditi...
Q17FM5        680 PEELL---YRCVQAVNQSHDaahaqmDVKLRSLICLGLNEQVLHLWMEVLCSCSE---IVHK-WYQPWSFIYSPGWV--- 749  yellow fever ...
KAI2597964     73 PEELL---YRAVQSVNVTHDavhaqmDVKLRSLICVGLNEQVLHLWLEVLCSSLP---TVEK-WYQPWSFLRSPGWV--- 142 
Q96C34        512 PKQSL---LTAIHMVLTEHDpfkrsaDSELKALVCMALNEQRLVSWVNLICKSGS---LIEP-HYQPWSYMAHTGFE--- 581  human
Q9W5C1        614 AKQSL---LSAVGMILAMHRpykrsnNAHFKAFVCAGLNSHLLVEWLNLILSCHE---LVDT-YYSADSYVARTGFR--- 683  fruit fly
Q17Q22        598 NKQSL---LSAIGTIIALHSpykrsyNSQFKAFICAALNAQKLTQWLHLIYQCKE---LVSS-YYTSWSYVANTGFR--- 667  yellow fever ...
Q7QH55        528 NKQSL---LSAIGSIIALHSpykrsyDSQFKAFVCAGLNAQKLTQWLYLIFQCKE---LVSS-HYASWSYVANTGFR--- 597  Anopheles gam...
XP_003965057  465 PKQSL---LWAIHSVLKEHGrykrgpDTKFKALVCMALNEQRLVSWLNLLCKSG----TLVHpHYQAWSYMAQTGFE--- 534  torafugu
XP_011604172 1189 KTQILfnlQVRVSELPQLRHs-----KQRFNAFLLGLLNTKFLDFWLSHLHSCTD---VLET-YYHPASFMRLSLSTcrp 1259 torafugu
2DWG_A        150 ---II-AGLLVGLNVIDANFCMKG 169  house mouse
Q94222        746 ---QI-KCDLRLLSQFSFNLSMSF 765  Caenorhabditis elegans
Q17FM5        750 ---QI-KCELRLLSQFAFNLNPDW 769  yellow fever mosquito
KAI2597964    143 ---QI-KCELRVLCCFAFSLSQDw 162 
Q96C34        582 ---SA-LNLLSRLSSLKFSLPVDL 601  human
Q9W5C1        684 ---DS-LRSIDALSRFDFDLPVDL 703  fruit fly
Q17Q22        668 ---DA-LKTLDRLTQYRFDLPVDL 687  yellow fever mosquito
Q7QH55        598 ---DA-LKTLDCLTQYRFDLPVDL 617  Anopheles gambiae str. PEST
XP_003965057  535 ----GaLRILGRISHLRFNLPVDl 554  torafugu
XP_011604172 1260 lfeEL-LLVLQPLSLLTFNLDLlf 1282 torafugu
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