Conserved Protein Domain Family
CDC45

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pfam02724: CDC45 (This model is not part of the current CDD release)
CDC45
CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in human, mouse and smut fungus among others. It also has a role in minichromosome maintenance. It is a core component of the CMG helicase (Cdc45-MCM-GINS), required for DNA synthesis during genome duplication. Structures of CDC45 confirmed that it is evolutionary related to bacterial RecJ nuclease.
Statistics
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PSSM-Id: 515133
Aligned: 108 rows
Threshold Bit Score: 354.209
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS98907      26 VLILVA-LEPDALCACRILTSLLKHDYIPHKIQPVAGYADLARVGRELVAPmmqtrgGNGGVVVCLGVGGTVDLATFFG- 103 
XP_002770517  28 IIFVSC-LNIDSLCSAKILSIIFKKELIQYQLIPVVGYSDLKNHFSNLDSD--------VTNVILIGCGAMLDLESFFE- 97  
XP_001483103  28 ILFVLC-LNIDALTSAKILCGVLRKELILYQLVPVVGYADLKRRYLALDTE--------VNNVILLGCGAMLDIESFFEv 98  
CCE79634      28 ILFVSC-LNIDALCSAKILSIILKKELIQYQLVPVVGYSDLKKHYSSLDSE--------VTNVIMIGCGAMLDMESFFE- 97  
XP_001383612  28 VVFVSC-LDIDSLCAAKIVSLLLRKELIQYQLIPVVGYSDLKGHYSKLDAD--------VSNVILIGCGAMLDLETFFD- 97  
XP_007373425  28 VIFVSC-LDIDSLCAAKILSLVLRKELIQYQLIPVVGYSDLKSHYAKLDSD--------VSNIFLIGCGAMLDLEGFFE- 97  
XP_036668312  28 VIFVSC-LDVDSLCAAKMFSLLLKKELIQYQLLPVVGYKDLKSHYDRLDDD--------VSNVMLIGCGAMLDIESFLE- 97  
1_pfamImport   1 VIFVSC-LDVDSLCAAKMFSMLLKKELIQYQLLPVLGYNDLKAHYNKLDYD--------VANVVLIGCGAMLDVENFLD- 70  
XP_001696501  27 VMCFAAcTDADSVCASQQLMNLFNREGIFFTLIPVDSYEEVKAHCEPLVQA------EEVKTVVLINCGATDDIRSLCE- 99  
XP_002946226  27 VLCLAAsVDADSVCASQLLLNLFNRESIHFSLVPVACYEEE------------------VKTVLLLNCGATEDVRSLCN- 87  
ERS98907     104 -LESdddddnla-------------sgelafgGVEVWVLDAHRP-WNLSNVFGGFplepagdsqtalaatptptlsgrvp 168 
XP_002770517  98 -INVddydvgngnrvetd-dlhddplkgganlRRKIYIIDGHRP-WNLDNIFGSSm------------------------ 150 
XP_001483103  99 eLQPd--------------------------mLRKVYIMDGHRP-WNLDNVFGLSm------------------------ 127 
CCE79634      98 -LDEdayvtddstlysni-klrqdgirdskqvWRHVYIIDGHRP-WNLDNLFGSSv------------------------ 150 
XP_001383612  98 -INIdelaydse------------sreglttlSIKIYVIDGHRP-WNLDNVFGSSv------------------------ 139 
XP_007373425  98 -LNPeefveerqeqvtnd-ldldlkkdtaipmKRKIYVMDGHRP-WNLDNLFGSAm------------------------ 150 
XP_036668312  98 -VNPeelldndaeqqed---dqdlndvkqnqfKRKIYVIDGHRP-WNLDNLFGSEv------------------------ 148 
1_pfamImport  71 -INPeelltedsfangnaatdnldlahslrnySRKIYVIDGNRQ-WNLDNLFGSDv------------------------ 124 
XP_001696501 100 -LPD----------------------------NVRIVIIDHHRPvWHGHNV----------------------------- 121 
XP_002946226  88 -LPS----------------------------NVRIVVLDHHRPvWHGHNN----------------------------- 109 
ERS98907     169 pgvrsgqieraykPGKGGMIVF---DDGDIEEDLGAERD---AYMALADMPEID-----DDghddlgessDEEEEEDD-- 235 
XP_002770517 151 ------------------LVCL---DDGFIEGNLDKEKI---AYRTLVEQEVDSe--------------eESSSSDDN-- 190 
XP_001483103 128 ------------------VVCF---DDGYIDSNLQQERE---AYQYLVEHEd------------------EEEDENEE-- 163 
CCE79634     151 ------------------FVCF---DDGYVDANLKKERE---AYEKLVSFDm------------------QSDGEETD-- 186 
XP_001383612 140 ------------------VVCL---DDGFVDSNLVDQKS---AYDVLVEQDe------------------EESEDEDE-- 175 
XP_007373425 151 ------------------IVCF---DDGFIDANLKTEKL---AYTNLMDQLQGe----------------EEDEEESEsd 190 
XP_036668312 149 ------------------VVCF---DDGYVDGTLSEEKK---AYEILILEGDe-----------------EDSGSESE-- 185 
1_pfamImport 125 ------------------VICF---DDGYVEGNLQEEKK---AYEALSVESDDDddd-----------deEEEEEEDP-- 167 
XP_001696501 122 -------------EDDTNTLVLvdeDDPV-------PKAsvpVYNPNEQEEDEEdsgseAS----------EAEKDDE-- 169 
XP_002946226 110 -------------DDDMDTLVLvddDDPV-------PKPavpSYDQQLDNEVA------------------QSDDSAS-- 149 
ERS98907     236 --DED---DEEDDEERPPA-----PRAGQKRK---SWLDDEee----dEDDGDDDRPHQRRRSNssspipdaprpksrpl 298 
XP_002770517 191 --DENefqDEEEEEDDADDndnddDIvi-------------------sSQDDPETSSRKRRKQEi--------------- 234 
XP_001483103 164 --DEV---EKSDDEATGEDvdtdeDVL---------------------------SISKKKL------------------- 192 
CCE79634     187 --EDE---DAEEDEEDDVNqdedeEQ------------EWNaedleirPDDDADTVEEKERRQRv--------------- 234 
XP_001383612 176 --DED---EESASSAEIDIssndeEIsf-------------------nSQDSEDAISRKRKIQEr--------------- 216 
XP_007373425 191 mtDED---DDEFEGDTDVDeqsdeELii-------------------nSQDSDDTVSRKRKLQEi--------------- 233 
XP_036668312 186 --LDS---AEEVEEETDVDlpsesELai-------------------sSQDSEDTISRKRKLQEr--------------- 226 
1_pfamImport 168 --EDS---ELSENETSGGDteadeEAai-------------------nSDDSEFTVARKRKLQEr--------------- 208 
XP_001696501 170 --EDQ---EAGVSGDGDEDeddlgVRPGRKRRrrsTGADQEerpakrsPEARAQARAERRKLAE---------------- 228 
XP_002946226 150 --ESD---GSDLDDVNDDDneegvGSDGEQTRkrhRGHDAGvsppkrgPAARAENVAARRKRAE---------------- 208 
ERS98907     299 lslrgreqpssdavafsdesrhdedgdgasssrrptasknaqktqkapSARTLRRRLLRLKHDNEAILRKYYRMGASYSE 378 
XP_002770517 235 ------------------------------------------------KMKKLKKQRKQQISSCEDIVETYYNQGTTIIT 266 
XP_001483103 193 --------------------------------------------------------RKSASNSAENLILSYYNQGTTVAT 216 
CCE79634     235 ------------------------------------------------ITKKIKKQRRKEISECEDVIESYYNQGTTIVT 266 
XP_001383612 217 ------------------------------------------------RLKNLKKQRKLEKTIHEETIQSYYNQGTTIMT 248 
XP_007373425 234 ------------------------------------------------KMKKIKKQRKREKSENQDKIQQYYNQGTAIIT 265 
XP_036668312 227 ------------------------------------------------HSRQLEKLKKQKRSLNEDKLQTYYNQGSTIST 258 
1_pfamImport 209 ------------------------------------------------LAKLLKRRRRKEQSSYEDVVRAYYNQGSTIGT 240 
XP_001696501 229 ------------------------------------------------------------------LIDAYYSDCNGYGK 242 
XP_002946226 209 ------------------------------------------------------------------EVDAYYSDRNGYGK 222 
ERS98907     379 PISSMMYSLASELGREDNDLLWLAIVGVTSMELYGRSSAGvgvsvrsadtsrpttgwmgmRGARIRQLLRDEVRRLNP-P 457 
XP_002770517 267 STTATIYALLSSIGETNIENLWLAIIGTSSLDNHYPE-----------------------VYDKIQPLFKEEVFRLNPs- 322 
XP_001483103 217 STTATMYALISSIGETTIENLWLAIVGTSSLDSYYPD-----------------------VYDKIQPLFNEEVYRLNPs- 272 
CCE79634     267 STTAIIYALLSSIGETNIDNLWLAIIGTSSLDDHYPE-----------------------VYDKIQPLFKDEVHRLSSs- 322 
XP_001383612 249 ATTTIVYALLASIGETSLENLWLAIIGTSSLDNQYPE-----------------------IYDKLQPLLKDEVLRLNPsN 305 
XP_007373425 266 ANSITIYALLSAIGETSLENLWLSIIGTSSLDNQFPE-----------------------LYDKLHPLLRDEVLRINPsN 322 
XP_036668312 259 ANTITVYALLTAIGETNLESLWIAIIGTSSLDSHYPE-----------------------IYDKLQPLLKEEVMRLNPe- 314 
1_pfamImport 241 ANTITVYALLTAIGETNLESLWIAIIGTSSLDSHYPE-----------------------IYDKLQPLLKEEVMRLNPn- 296 
XP_001696501 243 PSSLLLFALVNTAQHDDNFHLWCAIVGLTEQLLFHQISKQ--------------------QYNTWREGLEQKTHVqadp- 301 
XP_002946226 223 PSSLLLFSLCHELQHDDNFHVWCAIVALTEQLLFQQISKQ--------------------QYNTWRDKLAVHVTM----- 277 
ERS98907     458 datplalsgaangvtgrsspemGIIPTTAR-------SPEDT------------SIRLSPEPKFLLIRHWSLYDSMLHSP 518 
XP_002770517 323 ----------------------NTNNNADK-------TADST------------SLSIDKDYHLFLLRHWTLYDSFFYSS 361 
XP_001483103 273 -------------------------STSEK-------TADTT------------SLSVEKDYHLFLLRHWTLYDAFFYLS 308 
CCE79634     323 ------------------------NGEPEK-------TADSS------------TLTIDVDYHLFLLRHWTLYDSFFYSS 359 
XP_001383612 306 ns-------------------iSNNNINEK-------TADST------------SLSIERDYHLFLLRHWTLYDSFFYSS 347 
XP_007373425 323 e--------------------pASVSGSTK-------TADST------------SLSIEKDYHLFLLRHWTLYDSFFYSS 363 
XP_036668312 315 ------------------------HENTKK-------KADQS------------ILRVERDYHLFLLRHWTLYDSFFYSS 351 
1_pfamImport 297 ------------------------HESTKK-------RADHT------------MLRVERDYHLFLLRHWTLYDAFFYSS 333 
XP_001696501 302 ----------------------------------qeeLDNEAangllhiprqkvHVEPFDDLRLTLLRYWTIEDSLRYTG 347 
XP_002946226 278 -----------------------------HhdqdqedAAQDGissllsmprhkvHVEACEDLRLTLLRYWTIEDSLRYTC 328 
ERS98907     519 YLFS-RLKMWSETGLKRLHKLFAKMGVSLVQCKQSYSHMDMMLKRELRVKLLKYASLYNL--DGMVPTidtdgkdragak 595 
XP_002770517 362 HVNS-KLNLWTENGKKKLHKLFAKMGVSLAIAQQNWLYMDIGIKRQLPTIFNKYLPLYGL--EGIVRN------------ 426 
XP_001483103 309 HVNS-KLNLWTEEGRKRLHKLFAKMGVSLATAQQKWLYMDVTVKKQLPYIFNKYLPLYGL--EGIVRD------------ 373 
CCE79634     360 HVNS-KLNLWTESGRKKLHKLFAKMGVSLAIAQQKWLYMDITVKKQLPVIFSKYLPLYGL--ESIVRE------------ 424 
XP_001383612 348 HVNS-KLNLWREDGRKKLHKLFAKMGVSLASAQQKWLYMDVRIKRQLPFIFNKYLPIYGL--EGVVRE------------ 412 
XP_007373425 364 QVNS-KLNLWTEDGKKKLHKMFAKMGVSLAVAQQKWMYMDSRVKRQLPGIFHHYLPLYGL--EGIVRQ------------ 428 
XP_036668312 352 HVNS-KLNLWTDEGKKRLHKLFAKMGVSLAVAQQKWLYMDTKVKRQLPIIFRRYLPIYGL--EGIVRE------------ 416 
1_pfamImport 334 QVNSpSSSLWTDEGKKRLHKLFAKMGVSLAVAQQKWLYMDTKVKRQLPIIFRRYLPIYGL--EGIVRE------------ 399 
XP_001696501 348 YVAA-RLQTWRQKGLDNLRSLLTYMCIPLKHATTAYKGLREVYNSQLRAQLPRFAPQHMLawDSLHLS------------ 414 
XP_002946226 329 YVAA-RLQTWRQKGLDNLRSLLTYMCIPLKHASTAYKGLREVYNGQLRSQLPRFAPQHMLawDSLHFN------------ 395 
ERS98907     596 dgwGFVRSWGWRATLSAQDVAVVVGALLEVGKNQgaapvaghanggShasnasngtaaaaaAAAGDddale--------- 666 
XP_002770517 427 ---GFIRTFGYSGQLSAIECVESLTALLECDKRI------------Ldgnn------nfneEEDDElddedk-------- 477 
XP_001483103 374 ---GFVRTYGYRGQLLAMECVEALTALLECDRAQ------------Vlngdhpdd------------------------- 413 
CCE79634     425 ---GFIRTFGYTGQLSGIECVESLSALLECDRQA------------Ltgdy------gfrrEESTEndsdded------- 476 
XP_001383612 413 ---GFIRTFGYTGQLSAMECVEALTALLESDKRL------------Lsgdr------entpISGDEddsqdeq------- 464 
XP_007373425 429 ---GFIRTFGFTGQLSAMECVEALTALLELDKRF------------Ltsng------mdtqANENEqdpdaeeeeeahde 487 
XP_036668312 417 ---GFIKTYGYTGSLSAMECVEALSALLEFDEKF------------Iqesa------krneEDDKTldnedd-------- 467 
1_pfamImport 400 ---GFIKTYGYTGLLSAMECVEALSALLELDEKF------------Ihdsa------klneEDNRLidneee-------- 450 
XP_001696501 415 ---SFRLLYKHE-EISASDMVFALLGLLTDAK------------------------------------------------ 442 
XP_002946226 396 ---SFRLLYKHE-ELGASDMVFALLGLLTEAE------------------------------------------------ 423 
ERS98907     667 ----dddeSDPSEEWVPRFWDAYDALE----------------------SIEFLKDGLRTAKFLHRAIFNT-GTALIKKK 719 
XP_002770517 478 ---insriERKEKIWVNNFWSSWDALNmntntsksvsaklhstnfkkakGFDLLLQGLEHAKQIQQIIFRT-GMSLLERK 553 
XP_001483103 414 drlihqriEDKERIWVSNFWMSWDALStygtqnk--------sttkgnkGFDLLLEGLDHAKRIQQLIFRA-GMSLLERR 484 
CCE79634     477 --ainkriQQREKVWVNNFWSSWDALNntvstwkrtnpssvttalkkpkGFDLLLQGLEHAKQLQKIIFRT-GMSLLERK 553 
XP_001383612 465 -eriqdkiDRKEKAWINNFWSSWDALNmnp--------------------stLLLQGLEQAKVIQQVIFKT-GMSLLERK 522 
XP_007373425 488 eeriekqlQKKEKVWVNNFWSAWDALNmgntlqigat--tqktsfkkpkGFELLFQGLEHAKQIQQVIFRT-GMSLLERK 564 
XP_036668312 468 --kirkrmERKESSWLNNFWSSWDALNvtkslktsat---qsspfaklkGSELLFRGLEYAKQLQQITFRT-GMSLLERK 541 
1_pfamImport 451 --rirrrmRRKESSWLNNFWSAWDALNvnksltntt----snssftklkGSELLFRGLEYAKNLQQITFRT-GMSLLERK 523 
XP_001696501 443 --------PKEKSWHRAAFNDASNALHvq-------------------rNLNVVEKGIELAKRMCSDVVHEcGLMITSGK 495 
XP_002946226 424 --------PGNPDSQRTAFNNAQSALHvq-------------------rNLHIVERGVELAKQMCQDVVHEcGLMITAGK 476 
ERS98907     720 Q-ITHLHAFRMCIVKDG--PDAA--VFNHPGALTKLALWIGEALAEQERDATgrlahggR---GTPLVVASLNEKRGVYV 791 
XP_002770517 554 L-IKNLRLYRLCVLNDGsiPDLE--IFNNPLILSKLGSWLLENITELEFLNSv------SnksLKPLVVASLDVASDTYL 624 
XP_001483103 485 L-VKNLRLYRLCVLNDGaiPDLL--VFSNPLILSKLGTWLLENITELEFAN--------NsttLKPLVVASLDVPSDTYL 553 
CCE79634     554 L-IKNLHLYRLCVLNDGtiPDLK--VFSSPLILNKLGTWLLENITEIEFLNYa------GsqsLKPLVVASLDVASDTYL 624 
XP_001383612 523 L-VKNLRLYRLCVLNDGsiPDLS--IFNNPLMLAKLGSWLLENLSELFLIN--------SsqsLKPLVVASLDMATDTYL 591 
XP_007373425 565 L-IKNLKLYRFCVLNDGsiPDLH--IFNNPLMLSKLGSWVAENLTELDFTN--------EshtLKPLILASLDVDSDSYL 633 
XP_036668312 542 M-IKNLKLYRLCVLNDGavPDLE--IFINPLMLSKLGSWLIENLAELDFIN--------GnhsLKPLVVASLDVSSDTYL 610 
1_pfamImport 524 M-IKNLKLYRLCVLNDGavPDLE--IFINPLMLSKLGSWLIENLAELDFIN--------GnhsLKPLVVASLDASSDTYL 592 
XP_001696501 496 VkGGRNADYRWVNVAES--NGLAnpRFTHPAVLKYMALFLRDATSHRYSSNDa----------RRPMVVAGPPDEGGMCC 563 
XP_002946226 477 VkGGRSADYRWVNVADS--NALAnpRFRHPTVLKYMALFLRDATSCRYSSSDa----------RRPMVVAGAADERGLCC 544 
ERS98907     792 VVGTGGGGg------PDmlaqnrsaarqrqearaakaklredrrqarkaqrdeakerrraerrseenegeedeeqeeeee 865 
XP_002770517 625 VIGLAPKYprgmdnsTKakllqsk-------------------------------------------------------- 648 
XP_001483103 554 VIGLAPKYprgmsnsDAakmlhkn-------------------------------------------------------- 577 
CCE79634     625 VIGLAPKYprgidnsTKakilqq--------------------------------------------------------- 647 
XP_001383612 592 VIGMAPKYprgmdntTRaklmqgqqdd----------------------------------------------------- 618 
XP_007373425 634 VMGIAPKYprgmnnaTRaklaqeqar------------------------------------------------------ 659 
XP_036668312 611 VIGLAPRYprgmsnsEKakllqeqsn------------------------------------------------------ 636 
1_pfamImport 593 VIGMAPRYprgmsasEKakllqetkn------------------------------------------------------ 618 
XP_001696501 564 VVAVHAKHisgn-------------------------------------------------------------------- 575 
XP_002946226 545 LVSVHAKHisgn-------------------------------------------------------------------- 556 
ERS98907     866 esdssesdsesddddvdetlgetsrgFGLNRFGTAFQDVVAETNTRVRIDSFEHCVVEVKKEDLGGFLESLSMK 939 
XP_002770517 649 --------------------ddatitTRLNTFSVAFQQVANTSGAKVRIDSFDSSVIEIRKDDLSPFLEKLTLS 702 
XP_001483103 578 --------------------gdatvtTRLNTFSVAFQQVALTLGAKVRIDSFDSSVIEIRRDDLSPFLERLTLS 631 
CCE79634     648 --------------------nenstvTRLNIFSVAFQQIAKISGAKVRIDSFDSSVIEIRRDDLSPFLEKLTLS 701 
XP_001383612 619 ----------------qekngaptltTRLNTFSVAFQQLANTSGAKVRIDSFDSSVIEIRKDDLPPFLEKLTLS 676 
XP_007373425 660 ------------------dengetqmTRLNTFSVAFQQLSNTSGAKIRIDSFDSSVIEIRKDDLSPFLERLTLS 715 
XP_036668312 637 -----------------dkitaesmtTHLNTFSVAFQQLSNTSGAKVRVDSFDSSIIEIRKDDLAPFLEKLTLS 693 
1_pfamImport 619 -----------------dritaesmtTRLNTFSVAFQQLSQTSGAKVRVDSFNSSVIEIRKDDLAPFLEKLTLS 675 
XP_001696501 576 -------------------------klqKNPFARPFIETASALHIFQQKSAFENTTFHLRKEEVGPFLDRLQHV 624 
XP_002946226 557 -------------------------rlqNNPFARPFIETASALNIVPLKSAFENATYHIRKEDVTAFLGKLQDV 605 
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