Conserved Protein Domain Family
MOSP_C
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pfam02722: MOSP_C 
Major Outer Sheath Protein C-terminal domain
This is a family of spirochete major outer sheath protein C-terminal regions. These proteins are present on the bacterial cell surface. In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola. This domain forms an amphipathic beta rich structure with channel forming activity.
Links
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Statistics
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PSSM-Id: 280819
Aligned: 6 rows
Threshold Bit Score: 300.19
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O83055       436 DALLIVQWRWISLGAYVASAPTNVFGSMLFPRGSSDHFDCAAFVRVESKWYDSLSKLVSGLSGGVEARLYIPFTHGLYLE 515 Treponema pallidum
O83619       490 DALLTLQWRWFACGVYVATAPASVFGAMVFPTYGSTHTDGGGFLRVETKAGDAYTHLIDGLEAGMDVRCYIPLTHGLYID 569 Treponema pallidum
O83994       317 DALLSMQWKWLSSGAYFATAGANMFGKRVFSRQLTDYLDCAAFLKLETKSGDPYTHLLTGLNAGVEARLYIPFTYTSYVN 396 Treponema pallidum
O88138       400 DALLRMQWKWLSSGIYFATAGTNIFGKRVFATTRAHYFDFAGFLKLETKSGDPYTHLLTGLNAGVEARVYIPLTYIRYRN 479 Treponema pallidum
1_pfamImport   1 DALFTAQWKWLSSGIYFATAPANVFGTRVLDNTIASCGDFAGFLKLETKSGDPYTHLLTGLDAGVETRVYIPLTHDLYKN 80 
O83867       319 DALLTLGYRWFSAGGYFASXASNVFGGVFLNMAMREH-DCAAYIKLETKGSDPDTSFLEGLDLGVDVRTYMPVHYKVLK- 396 Treponema pallidum

O83055       516 PGsctpnstrgkkpqAFVLPPpg-vVHPGAHSALPVVGKLWLNYRITLAAHAWIRPMVSLYGATYGAQGFSYGPGgaagt 594 Treponema pallidum
O83619       570 NGk------------GYYVSPmgvwKLPDTHINLPVMGKVWARYLIPLGETAWLKPSLAVYGTTNRFNYNLKTEN----- 632 Treponema pallidum
O83994       397 NG-------------GIDYKK----TTMRGPINLPVVGKTWLSYQIALGSHAWLKPYAVVYGTTNRFN-TDKANN----- 453 Treponema pallidum
O88138       480 NG-------------GYELNG----AVPPGTINMPILGKAWCSYRIPLGSHAWLAPHTSVLGTTNRFNIINPAGN----- 537 Treponema pallidum
1_pfamImport  81 NN-------------GNPLPS----GGSSGHIGLPVVGKAWCSYRIPVQDYGWVKPSVTVHASTNRAHLNAPAAGgavg- 142
O83867       397 -----------------ALPP---------AIXFPVYGKVWGSYRHDMGEYGWVKVYANLYGGTNK-----KATPpaap- 444 Treponema pallidum

O83055       595 vkrnrtFRAGKNLYYQVGVAVSPFERCELLIEWSQGMLARRPYISLEHGSWPDK-RSELVCSCKVLW 660 Treponema pallidum
O83619       633 ------LVHERCVQYQVGLTLSPIEKVTLHAQWEQGQLEPTPYMVITETVTSRRyFGTFVCGMTINW 693 Treponema pallidum
O83994       454 ------LLREKAMQYHVGFTVSPIEKVEFDARWEQGRLATAPYMLITEDISSDKhFGTFVCGLKIAW 514 Treponema pallidum
O88138       538 ------LLNERALQYQVGLTFSPFEKVELSAQWEQGVLADAPYMGIAESIWSERhFGTLVCGMKVTW 598 Treponema pallidum
1_pfamImport 143 ---atyLTKEYCAQLRAGISASLIEKTVFSLDWEQGMLSDVPYLLVSECLTQG--IGRIVCGVTLSW 204
O83867       445 ---atkWKAGYCGYYECGVVVSPLEKVEIRLSWEQGKLQENSNVVIEKNVTER---WQFVGACRLIW 505 Treponema pallidum
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