Conserved Protein Domain Family
DUF222

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pfam02720: DUF222 
Domain of unknown function (DUF222)
This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.
Statistics
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PSSM-Id: 397024
Aligned: 19 rows
Threshold Bit Score: 189.88
Threshold Setting Gi: 81414919
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q73VY1         38 LRALERMEASRRRQIAVSHGVIAGL------AGEGPGNVGGP-VHKVIADRLRISYAEACRRLREAKQLSPRltltgqel 110 Mycobacterium ...
jgi:Mvan_0040  22 FEELSELAGQRNAIDGRIVEIAAQId-----RDGLVGITGARsVAALVAWKTGCSPHNAKTITTVADRLEE--------- 87  Mycolicibacter...
Q743Z8         17 STHREESMLVARRFAAVAALLRHRVattdrpEPEYAEIDGFEqTAAEVAAAMNLSAAAASYLVSYAETLDTR-------- 88  Mycobacterium ...
VBC:MMAR_1213  34 AAARAEARAAAERLAAIGDLFRLRLsq--hgNREDWVADTCDaVAAEVAAALNTSVAMGHSNLRYARAMRER-------- 103 Mycobacterium ...
O33360         34 SATRAENRAAAAQLVALGELFAYRWsr--cgGREEWVMDTMAaVAAEVAAALRISQGLAASRLRYARAMRER-------- 103 Mycobacterium ...
Q73S99         33 vfARVENRAAAEQLAAIGELFAYRLsr--csECEDWAVDTEAaVSAEVAAQLRIGQGLAAAKVRYARAMRER-------- 102 Mycobacterium ...
WP_012393989   23 EASRREAAAAAERLDVVGALFVLRCre--sgDRAEWATDTWEaVAAQVAAALRTSVAMGSSYLRYAMAMRNR-------- 92  Mycobacterium ...
Q741N7         31 EAARAEARAAAARLVAIAELLVLRCre--tgERADWAADAWEaVAAQVGAALGCSVAMGHSYLRYAMAMRER-------- 100 Mycobacterium ...
WP_011780947   16 SAARAESAAIARRLEAVAALFRSRKcd--yaEAGFLHTDVYEaVAAEVSAAQNISRSRAGYQVEMAVSLYTR-------- 85  Mycolicibacterium
WP_011730266   24 EAKRQENAATARRLFAIGELDTRRAid--laECNFWRTDPFEeVCAEVSAALRISRSRANWQVHLARVLRDR-------- 93  Mycolicibacter...
Q73VY1        111 ppeLPATAGVWREGMLDGQHLRVIEKFVRDLPETTPVRALEEAERFLAHQATLLRPDQLEKVAHQCALRINPDGKF---- 186 Mycobacterium ...
jgi:Mvan_0040  88 ---FPRCVTALGEGRLSLDQVAVIAEHAGQGSDAHYAHLAASASVSQLRTAVKSEPRP------------DPEPVRdpfa 152 Mycolicibacter...
Q743Z8         89 ---LPEVAALLAEGRTDWRTVRLIITRTSLVTDTELIAKLDRSLAARIGNWHGWSRQRIVNAVDAAVRTADPDAARe--- 162 Mycobacterium ...
VBC:MMAR_1213 104 ---LPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVR---- 176 Mycobacterium ...
O33360        104 ---LPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVR---- 176 Mycobacterium ...
Q73S99        103 ---LPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVAKADADAVR---- 175 Mycobacterium ...
WP_012393989   93 ---LPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVADVDRDAVR---- 165 Mycobacterium ...
Q741N7        101 ---LPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDATLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVR---- 173 Mycobacterium ...
WP_011780947   86 ---LPKVAEAFARGDIDLRMVQIVLARTKNV-EDDVIGGLDKAIAPKLSRWMRLSKNDLRDRVDLWVADFDPAAVR---- 157 Mycolicibacterium
WP_011730266   94 ---IPKVAAVFAQGDIDFRIVTKIATRTELV-DPAAMPALDDVLARRCPNWMRLSEPKLEERIDQCILRLDPDGQR---- 165 Mycolicibacter...
Q73VY1        187 -SDADRAR----QRGFTWCGq-RADGMSFGKLWASPELRANLDAWLARFAAPgMCNPDDeapcvagepDEESATKDSRTP 260 Mycobacterium ...
jgi:Mvan_0040 153 dADEEPEPapvpRPEITSTC---DADYTYWRIKLPHEQSARFTAALQSHKDR-LIAQHTrdhgtdptgDGDGDRGVQLPP 228 Mycolicibacter...
Q743Z8        163 -RRLAAEE----DRHIGISA--AENGMAEVHGSVAAAAATAFDRRLSQLAKQ-VCPA------------------DPRTL 216 Mycobacterium ...
VBC:MMAR_1213 177 -RSRRDAA----DRYVDCAP--LEPGMALVNGQVFAATAEALARRLDELAKT-VCAD------------------DPRTV 230 Mycobacterium ...
O33360        177 -RRKEYQA----QRQFWVGE--SQDGVCQIGGSLLAVDAHALDARLSALAGT-VCEH------------------DPRSR 230 Mycobacterium ...
Q73S99        176 -RAEKQAA----TRHVWIAE--MGEGLSHLEGTVSSPDAHALDKRLDALAAT-VCEH------------------DPRTG 229 Mycobacterium ...
WP_012393989  166 -RVAEAAD----GRFVDVDViaDGSGLAALTGSVLATAGRAFDRRLDELANT-VCAA------------------DPRTR 221 Mycobacterium ...
Q741N7        174 -RARDAVT----GRYLDVRA--NESGMAWVEGNVLGPDGHALDRRLDELASG-VCAG------------------DPRSR 227 Mycobacterium ...
WP_011780947  158 -VPPEAKD----NRYFDVTP--DVPGMAFAGGLLNARDAAALDQRLEAIAAT-VCSN------------------DPRSH 211 Mycolicibacterium
WP_011730266  166 -VTKRSED----SRYFTVQPa-DTPGMANAQGYLPAHDAAGFDKRLDAIAAT-VCPN------------------DPRTP 220 Mycolicibacter...
Q73VY1        261 AQRQHDALNALL----RGRLGDPKLGLHNGLP---------VTVVVSTTLRELTTGAGR----AVTGGGTLLPMRDVIRM 323 Mycobacterium ...
jgi:Mvan_0040 229 WPSAGEAFMELV----EAGWDAEATRRPHGQH---------TTVVVHVDIDTRVAALHL---------GPLLTDEERRFL 286 Mycolicibacter...
Q743Z8        217 DQRRADALAALAeg-rGLPCACGQPDCPARTGdqhaddgtgARVVINVVASDRTVYADGaepgYLEG-YGVIDADQVRRL 294 Mycobacterium ...
VBC:MMAR_1213 231 VQRRADALGTLAagqdRLICDCGRTDCPAAGApq-----qpSRVVIHVVAGRETVDGAGeapgVLPG-DGIIPAEIVREL 304 Mycobacterium ...
O33360        231 EQRRADALGALAggadRLGCGCGRADCAAGKRpa------aPPVVIHLIAEAATINGTGsapaSQMNADGLITAELVAEL 304 Mycobacterium ...
Q73S99        230 EQRRADALGALAagadRLGCRCGRADCAAGTGpa------aGPVVIHVIAERASVEGTGggpaVEVGAEGLLPAQLVAEL 303 Mycobacterium ...
WP_012393989  222 EQRRADAVGALVagsdRLACGCTSADCTAAARsa------pSNVVIHVVADQSTVDGTGhtpaVLLGAEGLIPASLIAEL 295 Mycobacterium ...
Q741N7        228 AQRRADALGALAagagRLACGCGSPDCPSAAApa-----prSTVVIHVVAEQATVAGRGatpaVVAGLDGLIPAQVIAEL 302 Mycobacterium ...
WP_011780947  212 NNLRADAAGALGrgesTLTCECGAEDCPAAVLre-----saAQVVIHILAEQATVDGDGdkagYLPG-FGVLPAEEVRAA 285 Mycolicibacterium
WP_011730266  221 DQRRADALGALGryrdTLDCQCGREDCTAVAErd-----avNNAMIHVLAEQSTLDGGNep-gYLPG-FGMLPAHMVREV 293 Mycolicibacter...
Q73VY1        324 ARHAYhyLAVFDEhsSRPLY-LGRSRRVASPDQRVVLYAKD 363 Mycobacterium avium subsp. paratuberculosis
jgi:Mvan_0040 287 LCDAT--CEVWFQrhGRPLG-TGRSTRTINRRLRRALEHRD 324 Mycolicibacterium vanbaalenii PYR-1
Q743Z8        295 AAAAH--LL-VANpaTSP---AAALRYQPSAALERAVRCRD 329 Mycobacterium avium subsp. paratuberculosis
VBC:MMAR_1213 305 AKSAK--LQp----mSTPI--LAETGYVPSPALMDFVRARD 337 Mycobacterium marinum M
O33360        305 AKTAT--LVp----lVHPGDaPPEPGYAPSKALADFVRCRD 339 Mycobacterium tuberculosis
Q73S99        304 AASAR--LMp----lVHPADsSPENRYTPSAALADFVRCRD 338 Mycobacterium avium subsp. paratuberculosis
WP_012393989  296 AKVAT--LRp----lMRPSG-RPESGYAPSAGLAEFVRCRD 329 Mycobacterium marinum
Q741N7        303 AASAR--LVp----vAVPEG-GPEPGYTPSARLADFIRCRD 336 Mycobacterium avium subsp. paratuberculosis
WP_011780947  286 AKTAK--LKp----vRLPGA-EPEKGYRPSAGLKDFLQWRD 319 Mycolicibacterium
WP_011730266  294 AKTAT--TKp----vTIPKD-KAQSGYRPNAELTEFIRWRD 327 Mycolicibacterium smegmatis
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