Conserved Protein Domain Family
DUF222

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pfam02720: DUF222 (485927 is an unknown moldel)
Domain of unknown function (DUF222)
This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.
Statistics
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PSSM-Id: 485927
Aligned: 17 rows
Threshold Bit Score: 186.419
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q73ZY6        37 LSLLQRCETVRRRLPVPEHPLINAL-----ARDASPAELGGR-LSHAIAEATLISRAEAARRVHTAADLGPRvgltgepl 110 Mycobacterium a...
P9WLT3        37 LAMLQRCEKIRRRLPAAEHPFINKL-----ADQTDQTELGGK-LPFALAERLHISRGEASRRIHEAADLGPRrtltgqpl 110 Mycobacterium t...
Q73ZI4        38 iRLLEVLEHQTRRLQVPGHQLINQI-----EQDATPAEIGGK-LAHLLADRLLITRAEAARRIDDARDLGVRrtltgepl 111 Mycobacterium a...
Q0RL20       111 DGAVLDCSALLARLAAVRVGLVREM-----RGRGSALREGATsTAALVRARLRIRPVDAQRLVDLALAVDDD-------- 177 Frankia alni AC...
O06798        22 FEELAELAGQRNAIDGRIVEIVAEL-----DRDGLWGVTGARsVAGLVAWKMGCSSGNAHTIATVARRLPE--------- 87  Mycobacterium t...
Q743Z8        17 STHREESMLVARRFAAVAALLRHRVattdrPEPEYAEIDGFEqTAAEVAAAMNLSAAAASYLVSYAETLDTR-------- 88  Mycobacterium a...
2_pfamImport   1 AAARAEARAAAERLAAIGDLFRLRLsq--hGNREDWVADTCDaVAAEVAAALNTSVAMGHSNLRYARAMRER-------- 70 
O33360        34 SATRAENRAAAAQLVALGELFAYRWsr--cGGREEWVMDTMAaVAAEVAAALRISQGLAASRLRYARAMRER-------- 103 Mycobacterium t...
Q73S99        33 vfARVENRAAAEQLAAIGELFAYRLsr--cSECEDWAVDTEAaVSAEVAAQLRIGQGLAAAKVRYARAMRER-------- 102 Mycobacterium a...
WP_012393989  23 EASRREAAAAAERLDVVGALFVLRCre--sGDRAEWATDTWEaVAAQVAAALRTSVAMGSSYLRYAMAMRNR-------- 92  Mycobacterium m...
Q73ZY6       111 pplLAATAAAQRAGLLGLEQVAVIRKFCHQLPGWIDQATRERAETDLANQGGQYRPEQLAALAGTLADCL---N------ 181 Mycobacterium a...
P9WLT3       111 pplLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCL---N------ 181 Mycobacterium t...
Q73ZI4       112 pprYAATAAAQRDGRIGASHVAVIRRFFDQLPCWVDAPTRDAAEADLARWAGEHRPESLRKVADRIACYL---N------ 182 Mycobacterium a...
Q0RL20       178 ---LAATGAALIAGTISVEQAQTIHLALRSLPRGVDVATRRSAEQFLLTSAARFDPAELARLGRHLRERLtdvDtspggd 254 Frankia alni AC...
O06798        88 ---FPRCARGMREGRLSLDQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRP---------------E------ 143 Mycobacterium t...
Q743Z8        89 ---LPEVAALLAEGRTDWRTVRLIITRTSLVTDTELIAKLDRSLAARIGNWHGWSRQRIVNAVDAAVRTA---D------ 156 Mycobacterium a...
2_pfamImport  71 ---LPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAKF---D------ 138
O33360       104 ---LPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARA---D------ 171 Mycobacterium t...
Q73S99       103 ---LPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVAKA---D------ 170 Mycobacterium a...
WP_012393989  93 ---LPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVADV---D------ 160 Mycobacterium m...
Q73ZY6       182 -------------------------PDGLY-----RDEDRAR-------RRSLTLGN-QQADGMSELRGWLSPELRATLE 223 Mycobacterium a...
P9WLT3       182 -------------------------PDGNY-----NDTDRAR-------RRSIILGN-QGPDGMSAISGYLTPEARATVD 223 Mycobacterium t...
Q73ZI4       183 -------------------------PDGVF-----HDEDRLR-------HRGLTLGA-QQPDGMSQLRGWLTPEARATIE 224 Mycobacterium a...
Q0RL20       255 npdpedngagnndgagnadadsdspPDGGEgagrsATSGAADgdgdpadRRRLWITD--LSDGMTRISGELDAEAAALLR 332 Frankia alni AC...
O06798       144 -------------------------PEP--------DFRPEP-------RPSITRSA---DEQFSCWRIKLPHVEAAKFD 180 Mycobacterium t...
Q743Z8       157 -------------------------PDAARe----RRLAAEE-------DRHIGISA--AENGMAEVHGSVAAAAATAFD 198 Mycobacterium a...
2_pfamImport 139 -------------------------RDAVR-----RSRRDAA-------DRYVDCAP--LEPGMALVNGQVFAATAEALA 179
O33360       172 -------------------------ADAVR-----RRKEYQA-------QRQFWVGE--SQDGVCQIGGSLLAVDAHALD 212 Mycobacterium t...
Q73S99       171 -------------------------ADAVR-----RAEKQAA-------TRHVWIAE--MGEGLSHLEGTVSSPDAHALD 211 Mycobacterium a...
WP_012393989 161 -------------------------RDAVR-----RVAEAAD-------GRFVDVDViADGSGLAALTGSVLATAGRAFD 203 Mycobacterium m...
Q73ZY6       224 AVLAKLAAPgMCNSLDespcvegtpSQHAIDGDARSAAQRNHDGLLAGL----RALLASGNLGQHNGLP---------AS 290 Mycobacterium a...
P9WLT3       224 AVLAKLAAPgMANPADdtpclagtpSQAAIEADTRSAGQRHHDGLLAAL----RALLCSGELGQHNGLP---------AA 290 Mycobacterium t...
Q73ZI4       225 AVLAKLAAAgMCNPDDpapvvdgqpGQEAIQRDSRSAAQRNHDGLNAAL----RALLAGGKLGQHNGLP---------AS 291 Mycobacterium a...
Q0RL20       333 TALDSLAAP-MPAI--------------DGTPDPRSPARRRADALVDFV----HRALDASAVPISGGVR---------PH 384 Frankia alni AC...
O06798       181 AALQSHLDA-LIAEYKrd------hDNSDGVSDQRPPLPGNVEAFLRLV----EAGWDAEVARRPHGQH---------TT 240 Mycobacterium t...
Q743Z8       199 RRLSQLAKQ-VCPA------------------DPRTLDQRRADALAALAeg-rGLPCACGQPDCPARTGdqhaddgtgAR 258 Mycobacterium a...
2_pfamImport 180 RRLDELAKT-VCAD------------------DPRTVVQRRADALGTLAagqdRLICDCGRTDCPAAGApq-----qpSR 235
O33360       213 ARLSALAGT-VCEH------------------DPRSREQRRADALGALAggadRLGCGCGRADCAAGKRpa------aPP 267 Mycobacterium t...
Q73S99       212 KRLDALAAT-VCEH------------------DPRTGEQRRADALGALAagadRLGCRCGRADCAAGTGpa------aGP 266 Mycobacterium a...
WP_012393989 204 RRLDELANT-VCAA------------------DPRTREQRRADAVGALVagsdRLACGCTSADCTAAARsa------pSN 258 Mycobacterium m...
Q73ZY6       291 IIVTTTLADLETAAGR----RLTGGGTLLPMSDVIRLSRHAHhyLA-IFDQ--GKALAlLYHTKRLASPAQRIVLYAKD 362 Mycobacterium av...
P9WLT3       291 IIVSTSLTELQSRAGH----ALTGGGTLLPMSDVIRLASHANhyLR-IFDH--GRELA-LYHTKRLASPGQRIVLYAKD 361 Mycobacterium tu...
Q73ZI4       292 IIVTTTLRDLESAAGK----GLTGGGTLLPMSDVIRLARHAHhyLA-VFDN--GKPLA-LYHTKRLASPGQRIVLYAKD 362 Mycobacterium av...
Q0RL20       385 LTVTIPWTTLVGRGGPa---ASTSWGQPLSRATVRRLACDAA--VSrIILDpaSVPLD-VGRTQRTVPGDLRRALVARD 457 Frankia alni ACN14a
O06798       241 VVMHLDVQERAAGLHL---------GPLLSESERRYLLCDAT--FE-AWFErdGQVIG-CGRTTRQINRRLRRALEHRD 306 Mycobacterium tu...
Q743Z8       259 VVINVVASDRTVYADGaepgYLEG-YGVIDADQVRRLAAAAH--LL--VANpaTSP---AAALRYQPSAALERAVRCRD 329 Mycobacterium av...
2_pfamImport 236 VVIHVVAGRETVDGAGeapgVLPG-DGIIPAEIVRELAKSAK--LQp-----mSTPI--LAETGYVPSPALMDFVRARD 304
O33360       268 VVIHLIAEAATINGTGsapaSQMNADGLITAELVAELAKTAT--LVp-----lVHPGDaPPEPGYAPSKALADFVRCRD 339 Mycobacterium tu...
Q73S99       267 VVIHVIAERASVEGTGggpaVEVGAEGLLPAQLVAELAASAR--LMp-----lVHPADsSPENRYTPSAALADFVRCRD 338 Mycobacterium av...
WP_012393989 259 VVIHVVADQSTVDGTGhtpaVLLGAEGLIPASLIAELAKVAT--LRp-----lMRPSG-RPESGYAPSAGLAEFVRCRD 329 Mycobacterium ma...
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