Conserved Protein Domain Family
DUF218
?
pfam02698: DUF218 (This model is not part of the current CDD release)
DUF218 domain
This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain. The entry includes SanA and Sfix from Salmonella typhimurium which are involved in Vancomycin resistance. These proteins may be involved in murein synthesis. This domain is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified.
Links
?
Statistics
?
PSSM-Id: 515116
Aligned: 426 rows
Threshold Bit Score: 49.9433
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
WP_273352231  136 DAIIVLGagltgrkPSPVLARRLDRAAqvarqlEAIRPAvvagqqgV---IIVSGGqgade-----------------pc 195 Corynebacteriu...
WP_012028706   31 DLLFVFG-------TRVDEELRAETAA------GLWQQG-------YfrhAIVSGGvtpga-----------------vl 73  Bradyrhizobium...
WP_012201309   22 DIILIPG---------GSHPQLMEKAV------DLLEMG-------MakyILPSGGknkklp---------------dyp 64  Lachnoclostrid...
CDE46744       29 DVILIPG---------SRHPANAIRAA------ELYRAG-------YapyVLPSGRhgaavdkfigvmpedraaypddyp 86 
23_pfamImport   1 DAIFLPG---------GSHPEQPEYAA------ELYRQG-------LtdwIVPSGGvsvkeekwhgvrs-kaeiysgdyr 57 
CDD30010       23 DAIFLPG---------GTHAEQPEYAA------ALYRQG-------YgkwLIPSGGvsvkkerwpgvss-kadvytgdyh 79 
CCF36283       34 TAVFCL---------CSLDKRVAARAA------QLFLDG-------YgeyLIYSGGvgklteg-------------rfte 78 
XP_013947292   30 DAIFCL---------CSLDTRIAAHAA------QLYLDG-------LapyLIYSGDsgaltkg-------------lfse 74 
3_pfamImport    1 DVIIGLG---------SYDPRVAERAA------DLFLAG-------MatwLVFTGKsghwtdr-------------lyka 45 
Q2YQW3         26 DIIIGLG---------SYDPRVAERAS------DLYLEG-------LapwLIFTGRsgrgtdk-------------lyka 70  Brucella abort...

WP_273352231  196 seAEAMARYLRTEAQLGGAdsrweVLQEDEATSTEENLANSTR-ILqergagtsgtntgtpgsntanpgsrtkrddemct 274 Corynebacteriu...
WP_012028706   74 seCALIKAAMVRRGIPAER-----ILEEHRAMNTGENVLFALP-VIdaalgl-----------------------anvrs 124 Bradyrhizobium...
WP_012201309   65 neADFLKTIAIKRGISSDI-----IICENKATNTYENALFSYE-LLmgkci-------------------------ditk 113 Lachnoclostrid...
CDE46744       87 teWAFLRDVLIKHGVPDSA-----ILREDEATFTWDNARKSAA-VLkaqgi-------------------------sart 135
23_pfamImport  58 sdCEFFTDVLVKNGVPQTA-----IIEESKSGHTRDNAFLSRK-AVdekgi-------------------------miks 106
CDD30010       80 tdCAFFIDVLRKNGVPASA-----IVGEFQSGHTRDNAFLSRQ-AVdekgl-------------------------vfrt 128
CCF36283       79 peAEVFAGIAGKLGVPDDK-----IIVEPRSGNTGENVRFTYD-LLkqrgl-------------------------gtks 127
XP_013947292   75 peAVVFAAIAREMGVPEDK-----IIVEPRARNTGENVRFTYA-LLkergl-------------------------efnk 123
3_pfamImport   46 seAEAFAEIAIRRGVPEEA-----ITIEPNATNIGENIRFSRErLApga-----------------------------is 91 
Q2YQW3         71 seAEAFAEIAIRRGVPERA-----IIIEPNATNIGENIRFSREkLAwda-----------------------------vs 116 Brucella abort...

WP_273352231  275 IVVVTSDFHVPRTR--W-HAKhaerdfpgvayrvvgaetPAG---A---RPAAY----------VREYV 324 Corynebacterium resistens
WP_012028706  125 LICLGNSWTARRYAmtV-QRHwpevekml--ltvdgfgvPRHlwhIhpeYRRRV----------LHEWd 180 Bradyrhizobium sp. ORS 278
WP_012201309  114 VILVCKAYHSRRALfsY-QKVfpanttffvcpvtdnrgiTKEnwfTrndYIELI----------MREVe 171 Lachnoclostridium phytofe...
CDE46744      136 AILCCRPFHARRALlyY-QTAmpetrflv--cpareegvNQDdwyLtqaGRTRV----------MGEvr 191
23_pfamImport 107 GIIVCKAFHARRCLmlY-QMAfpnvdmtv--cpvhcyniTKEnwyTtekGTDRV----------LGELA 162
CDD30010      129 ALIVCKAFHARRCLmlY-QLAfpdvsfkv--cpvpcyniTKEnwyKteaGLHRV----------LGELA 184
CCF36283      128 FVLVQKPYMERRTYatF-RKQwpdeatnf---tvaspslEFEeypDadnPKELVinimvgdlvrIREYP 192
XP_013947292  124 LVLVQKPYMERRTYatF-RKQwpdeataf---tvsspklSFDeypDasnTRELVtsimvgdlirIREYp 188
3_pfamImport   92 AILVTKPQTQRRVLatAaRQWpearas------itaplvSFEdqpTadhPVEML----------ISEMT 144
Q2YQW3        117 GIFVTKPQTQRRVHatMlRQWpearas------isaplvSFEeqpTaefPLEML----------IHEMT 169 Brucella abortus 2308
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap