7LC7


Conserved Protein Domain Family
QueH
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pfam02677: QueH (This model is not part of the current CDD release)
Epoxyqueuosine reductase QueH
The reduction of epoxyqueuosine (oQ) is the last step in the synthesis of the tRNA modification queuosine (Q). members of this family were predicted to encode for an alternative epoxyqueuosine reductase. Furthermore, it has been suggested that family members are a non-orthologous replacement of queG, responsible for oQ to Q conversion. QueH contains conserved cysteines that could be involved in the coordination of a Fe/S center in a similar fashion to what has been identified in QueG. No cobalamin was identified associated with recombinant QueH protein, indicating that the reduction activity is independent from cobalamin.
Links
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Statistics
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PSSM-Id: 515103
Aligned: 224 rows
Threshold Bit Score: 190.718
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7LC7_A          4 VLIHVCCAPDLLTTIFHVRDa-EF----FFYNPNIQPLSEYEKRREAVDKVANHFSLNVRYGE-YStEEirkWYTAV--- 74  Thermotoga mar...
15_pfamImport   1 LLLHICCAPCATGVIQKLKNdgGFlitgYYYNPNIHPTEENNARRNSVKALAEDENIHVIYSDlVMvNY---WKENL--- 74 
WP_015924851    3 VLLHMCCGPCSTYPVQELLEe-GVdiqgYFYNPNIHPIEEHKRRRENVEKFSKIKNIPVIYDDdFRqTE---WEGMK--- 75  Ruminiclostrid...
WP_003512259    3 LLLHICCGPCAVYPVNVLREe-GIyfegLFYNPNIHPYDEFIRRKENVKKLSEIKNVPVKYMDdFSqEI---WEKLG--- 75  Acetivibrio th...
WP_015709506    3 LLLHTCCAPCSVQCLETLRAe-DIrpdlFWYNPNIHPYTEYKARRDTLAQFVADIGLNLLMEDeYGlRS---FLAGL--- 75  Treponema prim...
WP_015711957    3 fLLHACCAPCSVQCVQAFKEe-GLtpdlFWYNPNIHPYTEYRSRRDTLSRFAMEEGLNLFEEDeYGlRL---FLAGLycg 78  Leadbettera az...
CDA81912        4 tLLHTCCAPCSVACIQLLRAe-GIepvsYWYNPNIHPYQEYKARRDTLMAYAPSVGVELIVQEdYGlRD---FCRAV--- 76 
CCY90628        4 VLLHCCCAPCSLSCIDPLRNe-GIepvaFWYNPNIHPWKEYEARRNCLIDYASKINMRVLVEEdYGlRE---FVKNV--- 76 
CCX42256        5 VLLHCCCAPCSLSCVDPLLTe-GItpvaYWYNPNIHPFKEYEARRDCLIEYMQKIGLELHIDEcYGlRT---FVQAV--- 77 
CCZ45939        4 ILLHSCCAPCSVYCVDTLRGe-GIepvsLWFNPNIHPWTEYDQRRSTLLEYGEKERVEVHILEdYGlRD---FVRAV--- 76 

7LC7_A         75 K-----DYKDLGegsKRCERCISFLLERTAQEARKRGHESFSTTLLASPRKNLPMIENIGKTIEeKYGVKFFFKNFRkgG 149 Thermotoga mar...
15_pfamImport  75 -------EGKKE---RRCNFCYSIRINQAAKTAAENGFEAFSTSLLISPWQDHEKVRRIAETACkKYGIEFVYQDFR--P 142
WP_015924851   76 -------GMGGS----RCLHCYSVRLESAAKLAVQKGCDAFTTTLLVSPYQKHDLIKELGEKYAaQYGTTFLYRDFR--P 142 Ruminiclostrid...
WP_003512259   76 -------EDNEK----RCNMCYALRIDKVAGYAKENGFDAFTTTLLVSPYQKHELIVELSKRAGeKYGIEFFYKDFR--P 142 Acetivibrio th...
WP_015709506   76 -------GQDYT---NRCTFCYRLRLEKTASFAAARGYDCFSTTLLISPYQKHDLIREAAEGMAeKYGIPFFYRDFR--P 143 Treponema prim...
WP_015711957   79 GdgasnHPWESP---ARCVFCYKLRLGKAAAYAAANGYDAFSTTLLISPYQNHDLIKENGEKFAaQYRLEFIYRDFR--P 153 Leadbettera az...
CDA81912       77 -------AEDID---HRCGHCYRLRLEQTARYASEHGFESFSSTLFVSPYQDHELLRQTADEVSaQYGVTFLYRDFR--P 144
CCY90628       77 -------VGDID---NRCTYCYETRLRKTAEFAAEHGFKQFTTTLLASVYQKHELIAAAGERFGkEFGVEFLYRDFR--P 144
CCX42256       78 -------ADDIS---HRCTYCYTHRIEQAARYAKAHGFSAFTTTLLASTYQAHDLIAAAGEKAAkEYGVPFLYRDFR--P 145
CCZ45939       77 -------AADID---HRCAHCYTIRLGTAAKYASEHGYEAFTSSLLISPYQNHELLKAVGETMAkKYGVEFLYRDFR--P 144

7LC7_A        150 AYQEGVRLSKELGIYRQNYCGCVFSLLE 177 Thermotoga maritima MSB8
15_pfamImport 143 FYRQGKNEAYRRGYYLQKYCGCIFSYNE 170
WP_015924851  143 GFRQGQQMAKDMELYRQKYCGCILSLpv 170 Ruminiclostridium cellulolyticum
WP_003512259  143 GFRQGQQEAKELGLYRQKYCGCIISYRE 170 Acetivibrio thermocellus
WP_015709506  144 GFREGQKQARERGFYIQKYCGCIFSEEE 171 Treponema primitia
WP_015711957  154 RFREGQRLAREREYYMQKYCGCVFSEEE 181 Leadbettera azotonutricia
CDA81912      145 GFRQGQQEARELGLYMQKYCGCVFSEED 172
CCY90628      145 NFRDGNQRARELGFYMQKYCGCVFSEED 172
CCX42256      146 NFRQGNQRARELGLYMQKYCGCIFSEED 173
CCZ45939      145 GFLAGQAKAREMGLYLQKYCGCIFSEED 172
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