2DRV,1TLJ


Conserved Protein Domain Family
TYW3

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pfam02676: TYW3 (This model is not part of the current CDD release)
Methyltransferase TYW3
The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner.
Statistics
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PSSM-Id: 515102
Aligned: 132 rows
Threshold Bit Score: 124.218
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DRV_A            15 KKEALXSLeiALRKGEVDEDIIPLLKKINS-IENYFTTSSCSGRISV-XEXPHFGDKVNa--KWLGKWHREVSLYEVLEA 90  Pyrococcus ...
Q8TZ89             7 KRRRLKELerAIERGEVDEAAIPVLETLNS-FEEYCTTSSCSGRVVVl-HEPEVGDKIGs--EFVAKWHEPPEPEEVREA 82  Methanopyru...
imbp:Hbut_0026    21 RRNYLDRLidDIRRGLVDSDIVDLLDALNS-VECIVTTSSCSGRIAVf-AAPSPGNKRLg--GIVHSWHRRINVDEFYTA 96 
WP_013337024      10 KSIFVKRLieESNQHRVDFDIYDFLLTFNKsLNDYYTTSSCSGRIALaKAPRLSYSKGSglfKFVAKWHRPVTYSEIINV 89  Vulcanisaet...
CBRAS:FFONT_0669   9 KSAFLERIkrDREIGYLDPGIEETLDLINS-REKSYTTSSCSGRISAv-DSEFPWKRDDe--HPIFKKHAPITEEELEDF 84 
12_pfamImport      3 KTMFIKRIesDREIGYLDPGIDETLSLINK-REKSYTTSSCSGRISIv-DTDYLWKRNEl--PLIFKKHSEVSSEELISI 78 
WP_013129589      12 KRAFWNRIleDLEIGYLDKDLLPLLIMLNL-DARIYTMSSCSGRITLv-DGDNPWSREDt--AVVFKKHTPLTQDEMASA 87  Thermosphae...
WP_011838748      14 KIEFWNRLweDLEIGYLDEDLIGILLILNT-DINIYTLSSCSGRITVs-DSTYPWSREEs--SVVFKKHVPITINEVLDV 89  Staphylothe...
Q9UX16             8 REKALNKIyhDKEIGYLDPDILGFLLAFYRnRNDVYTQSSCSGRITIv-DAEMPWDRKNs--TIIFKNHLRITEQDLEDV 84  Saccharolob...
1TLJ_A            10 REKALNKIyhDKEIGYLDPDILGFLLAFYRnRNDVYTQSSCSGRITI-VDAEMPWDRKNs--TIIFKNHLRITEQDLEDV 86  Saccharolob...
2DRV_A            91 IKKHR---SGQLWFLVRSPILHVGAKTLEDAVKLVNLAVSCGFKYSNIKSISNK-KLIVEIRSTERXDVLLG-ENg-eIF 164 Pyrococcus ...
Q8TZ89            83 VLKAPe--EGITWVKAQPPLFHVMCRDLEAAVRLRNIASEAGFKASSIRSVKSS-KVIVEILGGERMDVPAK--VngkLT 157 Methanopyru...
imbp:Hbut_0026    97 IRTALdtsYRFVWASAQPVILALYTCSEAVAKLVVDVAVSAGFKYAFYRRASSG-KYYVLILGVERIDIPLSiGGkqiIP 175
WP_013337024      90 INEVG---DGDVWLLVRAPIMHFVARDLNGALRILRIAREAGFKHSGIYSVTHD-GVVVEVQGEDRFEVPIV--IngrLI 163 Vulcanisaet...
CBRAS:FFONT_0669  85 LKVEP---KDIIWLIVSGPILHICCRDIEEAREMLRVARQAGFKHSGIMSISED-CFMVELISGTQLFLPLK--SrtkLF 158
12_pfamImport     79 FKKEP---MNTFWLIVSGPILHVRTLDIEEALFILNAGREAGFKHSGIMSYSED-GYLVELISGTQFNFPIK--NkngYL 152
WP_013129589      88 YRVKV---ARKLWIIVTGPIIHLSTSQISLALRILEMARKEGYKHSGIMHLSRSkGVLLELSTGIWVSQLLR--TvenPV 162 Thermosphae...
WP_011838748      90 LKKPV---VRRLWLNSTGPILHLSTNSLEYADKILSMARKAGLKHSGIISMNPDkGYIIELTSGVKISHLLR--SqniLL 164 Staphylothe...
Q9UX16            85 LSKNQ---VRRLWLIVQGPIIHIYAKNIETGWDILKIAREAGFKHSGILATNQK-GVLVELRTGIRMVHLLR--EsntER 158 Saccharolob...
1TLJ_A            87 LSKNQv---RRLWLIVQGPIIHIYAKNIETGWDILKIAREAGFKHSGILATNQK-GVLVELRTGIRMVHLLReSNt-eR- 160 Saccharolob...
2DRV_A           165 VGEEYLNKIVEIANDQXRRFKEKLKRLESKINA 197 Pyrococcus horikoshii OT3
Q8TZ89           158 LREKAWDSVVALCNDILRSGHERLSRLVEALKG 190 Methanopyrus kandleri
imbp:Hbut_0026   176 LSKEKLHDVVDVLNTYLTLAKSKLRRLKRAVAT 208
WP_013337024     164 VPTEELRRIVDVANETLIFGKFRLAHLIRLIev 196 Vulcanisaeta distributa
CBRAS:FFONT_0669 159 IEAGSMNDILFLVNESLSEGRNRLKRLNEALRa 191
12_pfamImport    153 INIEKIDYIAKLANSALVDGRRKLEKLNQFLKE 185
WP_013129589     163 IAEEDLGIIVREYNRILLEGKKRLNRLHSSLKQ 195 Thermosphaera aggregans
WP_011838748     165 AKEDSLEEIVKVANEVLLEGKKVLIRMFKVFRS 197 Staphylothermus marinus
Q9UX16           159 VDKDKIKTLVNVCNEVLARGKQKMNLLKDLLSS 191 Saccharolobus solfataricus P2
1TLJ_A           161 VDKDKIKTLVNVCNEVLARGKQKMNllkdllss 193 Saccharolobus solfataricus
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