1TLU,2III


Conserved Protein Domain Family
AdoMet_dc
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pfam02675: AdoMet_dc (This model is not part of the current CDD release)
S-adenosylmethionine decarboxylase
This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesised as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity.
Links
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Statistics
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PSSM-Id: 515101
Aligned: 213 rows
Threshold Bit Score: 66.3894
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TLU_A               7 HLVAEFYECDREVLDNVQLIEQEMKQAAYESGAT-IVTSTFHRF----LpYGVSGVVVISESHLTIHTWPEYGYAAIDLF 81  Thermotog...
17_pfamImport        1 HVLIDFYNC-KATFTEAEDLQPLVERAFDLVDT--PVEGITFFH----IdDELTCIAVSGNAHICIHAYPTLSYVAVDIY 73 
28_pfamImport        1 HLLVDCYGCKKEILLSSAEILNTMSDSAVYLGL--NVEDTYFHD----GeEEITVSAYGPRSHICIHAYPDMGYVAIDIY 74 
CDA50507             8 HLLVDCYGCVQEEITSSKELISVMNQAAKNLGI--EVEDTFFHE----DeEEITLAAYGKKAHVCIHAYPQLGYAAVDIY 81 
WP_004074803       169 stsVDVYDCSSDMIKDPDCIKKIVSRLCEKLGIVdTENISSVHYdeteTaAGFSMTRSIQTSGISGYFAHATHTAYLDIF 248 Desulfoba...
WP_011833515        27 ctsIDLKECDPATIRDAEKIHQFVLELADLIDMKrFGEPQIIHFgpneRvAGYSMTQLIETSLLSAHFANDTNAAYIDIF 106 Methanoco...
Q8EXA2             178 ltsIDLESCNPALIRDADAIRRYVLELCDLIEMKrFGETVVVHFgedeRvAGYSMFQLIETSCISAHFANETNTSYIDIF 257 Leptospir...
licsiro:TALC_00987  27 lvSIDLGECDHQKISDGKYIAQFAIDVCKEIKMKrYGEPYVVFFgdepKvQGYSLCQLIETSMISGHFAEDTDRAFVDVF 106
29_pfamImport        1 ---LDISGCDPEKIRSKEIITQFAIDLCEYIKMKrFGDPIVVRFgadpKvQGYSLAQLIETSMISGHFAEDTNKAFIDVF 77 
WP_013559699        30 HLVLNLYDCDPERIRSAEVIRRYVIELCDLIEMKrFGEPIIVDFgedpRvSGYSLVQLIETSNITGHFANQSNAAYIDIF 109 Anaerolin...

1TLU_A              82 TCGEDVDPWKAFEHLKKALKAKRVHVVEHERG 113 Thermotoga maritima
17_pfamImport       74 SFNIDLKTSQIMSALKVNLRSDRIKATSIRRG 105
28_pfamImport       75 SFDPELIPAKTMKAIRALLKPERIRATSVKRG 106
CDA50507            82 SFDCDILPARAMAVLRSALEPEKIRATSVKRG 113
WP_004074803       249 SCNT-YEPRELAEFALSYFGGSHYKMRVALRq 279 Desulfobacter postgatei
WP_011833515       107 SCKE-YAPSVAAEFCRKFFGAKRMNNTVFFRs 137 Methanocorpusculum labreanum
Q8EXA2             258 SCKC-YDPKVAAEFTRKFFQGDAMRLTVTNRf 288 Leptospira interrogans
licsiro:TALC_00987 107 SCKE-FPPEKTAKYVAEYFGAKKMEYSVSFRd 137
29_pfamImport       78 SCKE-YPPKKAAKFCMDYFGGTEVDYSVIFR- 107
WP_013559699       110 SCKK-FDPEKAAIFTIETFGAGKAKGTFFNre 140 Anaerolinea sp.
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