6CB2


Conserved Protein Domain Family
BacA

?
pfam02673: BacA 
Bacitracin resistance protein BacA
Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol. More recent studies show that BacA has undecaprenyl pyrophosphate phosphatase activity. Undecaprenyl phosphate is a key lipid intermediate involved in the synthesis of various bacterial cell wall polymers. Bacitracin, a mixture of related cyclic polypeptide antibiotics, is used to treat surface tissue infections. Its primary mode of action is the inhibition of bacterial cell wall synthesis through sequestration of the essential carrier lipid undecaprenyl pyrophosphate, C55-PP, resulting in the loss of cell integrity and lysis. The characteristic phosphatase sequence-motif in this family is likely to be the PGxSRSGG, compared with the PSGH of the PAP family of phosphatases.
Statistics
?
PSSM-Id: 396994
Aligned: 866 rows
Threshold Bit Score: 104.837
Threshold Setting Gi: 257169982
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6CB2_A         30 AAILGVVEGLTEFLPVSSTGHM--IIVGHL-Lg----FE---GDtaKTFEV----------VIQLGSILAVVVMFWRRLF 89 
CCX93837        8 SFLYGLFSGLTDILPVSAEAHR--ILMLKC-FgiqssT--------ELMKL----------FAHLGVFGAMYFSCRKQIV 66  Firmicutes bac...
CDA12453        6 AIFQAIGQVLTYIFPLSESGHS--AIFHDF-SgrftgSCselTG-----------------LIHIGIALGIIAAFWKVFL 65  Anaerotruncus ...
CDC33691        6 AIFQAIGQAFTWVFPVSESGHS--VIFHNF-SgrftnACsqlTG-----------------VIHIGIAIGLFIAFYKLFI 65  Eubacterium sp...
Q5JGF5          8 ALLSGILAALTSWLPMSPEGSFgrLIDGVIsY--------------TAFLV----------PAYAGIMFSVLYRYRERLS 63  Thermococcus k...
Q8ZYX0          6 AAILGVVQGISEWLPISSKTQI--MLVSIW-L----------------LNAspeyayslglFLEAASVLAALIYFRGVYL 66  Pyrobaculum ae...
jgi:Cmaq_1570   9 GIILGIVQGISEWLPISSKTQI--MMTSIY-A----------------LHLsfnqayalglFLEAGTVLAALIYFRREVW 69  Caldivirga maq...
CCC81800        7 GAILGLVQGISEWLPISSKTQI--MFVSTY-L----------------LGLtfgaayafglFLEFATLAAAVIYFRREVW 67  Thermoproteus ...
jgi:Msed_1011  20 GIVLGLVQGISEWLPISSKTQV--LIASTF-L----------------LGLpfslayafglFMEIGTIFAAVIYFRREIV 80  Metallosphaera...
Q97X94          7 GVILGIVQGISEWIPISSKTQV--LIVSST-L----------------LGLsfnvaysfglFMEIGTIAAAIFYFRSEIS 67  Saccharolobus ...
6CB2_A         90 G-----LIGihfgrPLqheg-------eskgRLTLI-------HI---LLGMIPAVVLGLLF--H--DTI-----KS--- 135
CCX93837       67 RihrarRLArvpkhRRrrpld------trslMDFS---------L---LRTMLIPVILGFLL--N--RYVeplkeKL--- 121 Firmicutes bac...
CDA12453       66 K-----LIFefvltGKelftkkldlkktansRKFMYytfipyiFM---LAYLIPVGSTNIY------GVLhayayDG--- 128 Anaerotruncus ...
CDC33691       66 S-----LFKnffatWNdifhkrldlknippqREFMFmtilsfvFF---IVYAIPAGKYG-----NvyMLFnrtshNK--- 129 Eubacterium sp...
Q5JGF5         64 KeplmaLRGaet------------------------------seLqyfVLGFLLTLLLGLP--------LakpltAHnaa 105 Thermococcus k...
Q8ZYX0         67 K-----ALRgfvgdAEg-------------rRWLVY--------I---LVTTLVTAVVGLPLyyVarKWLvvghsAG--- 114 Pyrobaculum ae...
jgi:Cmaq_1570  70 G-----ILKalvlrGSky-----------dyMMLKY--------I---VVITILTGLVGVPLylTiaD-SirgigIG--- 118 Caldivirga maq...
CCC81800       68 G-----VLRalalrGSpe-----------drLLLKY--------L---VVVTLVTAAVALPIylYfsE-Lsg-pvVG--- 115 Thermoproteus ...
jgi:Msed_1011  81 R-----LVKalvgrGTsq-----------dvKLLKF--------V---VVITLITGMIGVPLylFviN-LvtsavVG--- 129 Metallosphaera...
Q97X94         68 G-----LLKalvrmSSrre----------dyLLLKF--------L---VIVTIITGLVGVPLylF----VislpiLG--- 114 Saccharolobus ...
6CB2_A        136 -----LF--NpinVMYALVVGGLLL----IAAE-------CLkpkepRapGL-D--D--MTYRQAFMIGCFQCLALWP-- 190
CCX93837      122 -----IW------IAVLLFLNGIILyipqFFPT------------------S-NrdSrmLSRVEGLLVGLGGALGILP-- 169 Firmicutes bac...
CDA12453      129 -----NLvsE----GICFLVDAVLL----LFAYfrlkkneKG-----T--Q--------LSLPAVLVVGCAVFF-ALPvs 179 Anaerotruncus ...
CDC33691      130 -----TIlgE----GVCIALLGVLL----IVTNs----------------lInSnrNklPNWANAVILGLIGFL-ALPtg 179 Eubacterium sp...
Q5JGF5        106 fdvfnLI------LAFLITFFGLTWpgltVLKG------------------AeDriPskPSFLDAVLAGVFQSFSSTG-- 159 Thermococcus k...
Q8ZYX0        115 -----FLmiV---LGLAVVLNAVFLqrarFSAG------------------LkAfdN--MSLRDMAIVGIAQAVSVLP-- 164 Pyrobaculum ae...
jgi:Cmaq_1570 119 -----LPmiA---LGLILIADSILI----AFSRl-----rYM--------PRkSlsD--LRMWEVAVIGVVQGIAALP-- 169 Caldivirga maq...
CCC81800      116 -----APmiA---LGLVLIGDALLI----KLSRe-----rHT--------PRrGlsE--LGWRDLLLIGVAQGLAALP-- 166 Thermoproteus ...
jgi:Msed_1011 130 -----IPmtV---LGVILVLDGIVI----YLTRk-----rYV--------PRrGlnE--LTWRDMVIVGIAQGLAALP-- 180 Metallosphaera...
Q97X94        115 -----LPmtV---LGVVLLIDGIVI----YLSRk-----nYF--------PRkGlhD--LKLRDIIIVGIAQGLAALP-- 165 Saccharolobus ...
6CB2_A        191 GFSRSGATISGGMLMGVSRYAASEFSFLLAVP-MMM---GAT---A------LDlyksWG---FLTsgdi-------pmf 247
CCX93837      170 GVSAVGSALSVASICGVERSYGLNMALLM----NMFiqvGLI---V------LD----VLa--LISvgagtlsflilvry 230 Firmicutes bac...
CDA12453      180 GLSLCAIVIAILALFGTNPKIAFRYFISLSAP-ILL---VHG---IieiatcVS-------------------------- 226 Anaerotruncus ...
CDC33691      180 GCSFMGAIFAFMILLGMSQKYAIRYAVTMSVP-TLI---VMG---IielcvaVT-------------------------- 226 Eubacterium sp...
Q5JGF5        160 GASRTGLVTLALVLPGHKAENVLEWGFLIAPAyHLI---RLLylgAyegdtlLG-------------------------- 210 Thermococcus k...
Q8ZYX0        165 GLSRSGATVTALLLLGYKPEEAFRASFVL-VPvAGL---GATalayl-----------------------------segg 211 Pyrobaculum ae...
jgi:Cmaq_1570 170 GVSRSGVTVSAMLLLGLNPEDSFKLSFISMIP-AAI---GAS---I------------VPallTKHlfstlitdvntyti 230 Caldivirga maq...
CCC81800      167 GVSRSGATVSAMLLLGVRPRDAFRLSFLALIP-AAL---GAT---G------------VAllfSRHkiasavalvspqgl 227 Thermoproteus ...
jgi:Msed_1011 181 GVSRSGMTTSAMILLGVKPEEAFRLSFLSLIP-AAL---GAI---G------------VTvifSKAevvqavhlinvtgl 241 Metallosphaera...
Q97X94        166 GVSRSGMTTSALILLGVKPEEAFKLSFISLIP-AAL---GAI---S------------VTvlfSKHevsqavhsvslsgl 226 Saccharolobus ...
6CB2_A        248 AV-------GFITAFVVALIAIKTFLQLIKRIS----FIPFAIYRFIVAAA 287
CCX93837      231 LV-------TAAVSFGAALLGVKLMRLLAANNG----YALLAVYCWGVSLF 270 Firmicutes bacterium CAG:110
CDA12453      227 YVnifagiiGVVIAIALTFIASKFLLQIVKSNS----LNYFSYYGFTVGGL 273 Anaerotruncus sp. CAG:528
CDC33691      227 KInilsaiiGLVISIIASFFAIKLFIFVLKKRA----LNYIAYYDISIGVI 273 Eubacterium sp. CAG:251
Q5JGF5        211 FI-------TAVTAFFVSLGIMEVLVRTAQHLGtrrfLTLFGLIGVLLNLG 254 Thermococcus kodakarensis KOD1
Q8ZYX0        212 AVataeallAMAIGIVISIITIKALLEFAKSKH-------VVLVNVVIGLL 255 Pyrobaculum aerophilum str. IM2
jgi:Cmaq_1570 231 IT-------AIVIAALVSIVLIDALIKFARGRH-------VVVLTALLGAL 267 Caldivirga maquilingensis IC-167
CCC81800      228 AL-------ATAVAVVVSLLLIEMLLRLASSKR-------IVPLVASLGVI 264 Thermoproteus tenax Kra 1
jgi:Msed_1011 242 AV-------SMIVATGISLVLIDALLKFARSGR-------VLILVFSLGVL 278 Metallosphaera sedula DSM 5348
Q97X94        227 LI-------SIVVATFVSIFFINALLRFARTNK-------VVLLVIILGIM 263 Saccharolobus solfataricus P2
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap