1ONN,3IIE,1R0K,8JNV,4RCV,3A06


Conserved Protein Domain Family
DXP_reductoisom
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pfam02670: DXP_reductoisom (This model is not part of the current CDD release)
1-deoxy-D-xylulose 5-phosphate reductoisomerase
This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases. This enzyme catalyzes the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH. This reaction is part of the terpenoid biosynthesis pathway.
Links
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Statistics
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PSSM-Id: 515096
Aligned: 74 rows
Threshold Bit Score: 113.354
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1ONN_A   4 LTILGSTGSIGCSTLDV--VRHN---PehFRVVALVAGKNVTRMVEQCLEFSPRYAVMdDE-ASAKLLKTMLQQqg-srT 76  Escherichia coli
Q9WZZ1   6 LVILGATGSIGTQTLDV--LKKV---Kg-IRLIGISFHSNLELAFKIVKEFNVKNVAItGD-VEFEDSSINVw------- 71  Thermotoga maritima MSB8
Q73K78   6 VVVLGAGGSIGKNSLEI--IRRF---PdrFELAGFSVHSNSGFAKTLLAEFT-----------DAQFVSTKKkn---snL 66  Treponema denticola A...
Q8F146   5 VCLLGASGSVGESTLKV--LRAH---PekFRLHSFSVHSNLEKAKEIQKEFSPDFICVsSDfADVGVLGNKLGr-----T 74  Leptospira interrogan...
Q7M9M7   1 MILLGSTGSIGQNALSL--ARDF---R--LPVEVLVAGHNLSLLNAQIAEFQPKIIVIaDS-SRASELSLPKd------S 66  Wolinella succinogene...
Q9PMV3   1 MILFGSTGSIGVNALKLaaLKNI---P----ISALACGDNIALLNEQIARFKPKFVSIkDS-KNKHLVKHDRvf------ 66  Campylobacter jejuni ...
P56139   1 MVVLGSTGSIGKNALKI--AKKF---G--IEIEALSCGKNIALINEQIQVFKPKKVAIlDP-SDLNDLEPLG-------A 65  Helicobacter pylori 2...
Q7VIT0   1 MILLGSTGSIGTNALEV--ASHF---D--IPIESLCAGKNITLLNQQIAHYAPKNVCIaDK-NDAHKLINGN-------Y 65  Helicobacter hepaticu...
8JNV_A   5 VAIFGSTGSIGTNALNI--IRECnkiEnvFNVKALYVNKSVNELYEQAREFLPEYLCIhDK-SVYEELKELVKNikdykP 81  Plasmodium falciparum...
3A06_A   6 LVILGATGSIGTQTLDV--LKKV---Kg-IRLIGISFHSNLELAFKIVKEFNVKNVAItGD-VEFEds----------sI 68  Thermotoga maritima

1ONN_A  77 evlsGQQAACDMAAlEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCG 132 Escherichia coli
Q9WZZ1  72 ---kGSHSIEEMLEaLKPDITMVAVSGFSGLRAVLASLEHSKRVCLANKESLVCGG 124 Thermotoga maritima MSB8
Q73K78  67 kheiDEEAVRRLIEkSKADIVINGIAGSAGLKASVEVIKSGLDLALANKETIVEAG 122 Treponema denticola ATCC 35405
Q8F146  75 qilyGESSLCELVRePEVEIVITAIVGSVGLRPTIAAITAGKRLGIANKETLVTSG 130 Leptospira interrogans serovar Lai str. 56601
Q7M9M7  67 kllfGEEGIIESLHlAQSSFVLNALVGFLGLRPTLESLRLGKTLALANKESLVAGG 122 Wolinella succinogenes DSM 1740
Q9PMV3  67 ---iGQEGLEQILTeCQDKLLLNAIVGFAGLKSTLKAKELGKNIALANKESLVVAG 119 Campylobacter jejuni subsp. jejuni NCTC 11168...
P56139  66 evfvGLEGIDAMIEeCTSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAG 121 Helicobacter pylori 26695
Q7VIT0  66 klffGSEGILEMIEsSHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNAG 121 Helicobacter hepaticus ATCC 51449
8JNV_A  82 iilcGDEGMKEICSsNSIDKIVIGIDSFQGLYSTMYAIMNNKIVALANKESIVSAG 137 Plasmodium falciparum HB3
3A06_A  69 nvwkGSHSIEEMLEaLKPDITMVAVSGFSGLRAVLASLEHSKRVCLANKESLVCGG 124 Thermotoga maritima
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