2GVI,3D00


Conserved Protein Domain Family
FmdE
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pfam02663: FmdE 
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FmdE, Molybdenum formylmethanofuran dehydrogenase operon
This entry represents the FmdE protein that is encode by the molybdenum formylmethanofuran dehydrogenase operon. FmdE does not co-purify with the molybdenum isozyme that is formed by FmdC and FmdB. The domain is typically found as a single copy, but is repeated in some sequence two to three times. It is also common place to find this domain co-occurs with a zinc-beta ribbon domain, suggesting that is may bind nucleic acid and be involved in transcription regulation.
Links
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Statistics
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PSSM-Id: 426909
Aligned: 160 rows
Threshold Bit Score: 49.8776
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2GVI_A            16 FHGHKCPYXPXGYRAGSYALKIA------GlekekDHRTYLLSEXSpedxnGCFNDGAQAATGCTYGK------------ 77   Thermoplas...
WP_012662537     132 FHGHSCEALYYTAAICRLICDQMfpdgvvD-----RTILRGIVGQS-----PCIADSMAYITGGRLQF------------ 189  Desulfobac...
jgi:TOPB45_0891   72 FHGHLCDGLVIAYIEIKEVLKLLfpdgivD-----KTDLIAVSKNG-----PCWVDAVSYLTGARINF------------ 129  Thermodesu...
Q8TW59           248 RHDHLCPGLISGMLIVDKLLREGka---------------eAVRFYvacpiWCKDDAIYTTLDLTQGK------------ 300  Methanopyr...
O26770           667 FHDHACPGVSPGYLITEYIFNNYpl--------keDENYIYLGNTI-----YCKDDAIVYRLGVSPGQ------------ 721  Methanothe...
jgi:Mfer_0216    259 FHGHLCAGTICGYAMVETLLKYYpp--------kgGAMGEGVSYIVlgvpgGSDDDVFVYSMDATPGKrayigynttndp 330  Methanothe...
WP_023991716     287 YHGHVCLGTISGQAMVSLLLKYFppgvygD-----DGELEATSYRAigvpgNSDDDAFGYSLDLTPGKrsyvgyfteeds 361  Methanobac...
O27400           275 FHGHMCLGTISGYAMSKTIYMYYppiqdwSt----GSPIEITSYVTigvpgGSDDDALILALDNTPGKrsylgfdttgag 350  Methanothe...
O26770           287 FHGHMCLGTISGYAMSLTLLKYYppvmdfTn---pGSPGEITSYVTvgvpgDSDDDSLLMFLDTTPGKggsysgfnttat 363  Methanothe...
NZAGRC:Abm4_1108 301 FHGHICEGTLGGYTITKALLQYYppiqetGvg--nQSPGDITSYKIlgvpgDSANDAVLFFLDATSGKrsyigfnttstg 378  Methanobre...

2GVI_A            78 ------------------GLFSLLG-----------------YGKLAL--ILYRP-----GRK-AIRVHVRnsfxdelst 114  Thermoplas...
WP_012662537     190 ------------------GTLSMDP-----------------SLGHAV--VIQRI-----DTGeTWMGVWKdgiqswnak 227  Desulfobac...
jgi:TOPB45_0891  130 ------------------KTLRIDN-----------------SIGDGF--IIQRI-----STGeTYQVHLKpgvfpeems 167  Thermodesu...
Q8TW59           301 ------------------RNHFVFHpdsrerdllnrklggspAGVFVL------------QEGeDLKALVAtfkwvnwga 350  Methanopyr...
O26770           722 ------------------GTYFNLRvpgtend----peneyaYGGNIE--GILVIwdnknKVGrAVVIDFKwpqfdtsdc 777  Methanothe...
jgi:Mfer_0216    331 n----ivgfirwdsnnkkGTLIVMK-----------------YDVKELaeEFKKIyglniKEDtPIELKFNswlv----- 384  Methanothe...
WP_023991716     362 v-----vgfirwcastnlGTLIIMK-----------------FNEDVVtqLFKQEtgitaYSGiAAELLFNswli----- 414  Methanobac...
O27400           351 aed-smvgfirwnsrtntGTLVVMK-----------------FDQQALidTYKREtgvsmV----QELKFNawlv----- 403  Methanothe...
O26770           364 gadtnlvgfirwnpntlkGDLIVMK-----------------FDKEALrrQFQQQtg------knTELEFNawli----- 415  Methanothe...
NZAGRC:Abm4_1108 379 aks-nmiafirwndktnnGTIVVME-----------------YNSKKNkaLFEKEtg-ikGNGsLEQLKYNtwwi----- 434  Methanobre...

2GVI_A           115 rasdffryrkq-----gyepseipagaidpvlewiSSLEDE 150  Thermoplasma acidophilum
WP_012662537     228 kifgtpnkanpipykrwsnwkyepetpadqlddckiswdyd 268  Desulfobacterium autotrophicum
jgi:TOPB45_0891  168 kleakikklrfegksvdpedidrlekmaedlikklLNTPPT 208  Thermodesulfobacterium geofontis OPF15
Q8TW59           351 vfgk------------------laragwgsvkgrvLNSMIR 373  Methanopyrus kandleri
O26770           778 atndakre----------kqiagfislykgeipsyMTAPPV 808  Methanothermobacter thermautotrophicus str. Delta H
jgi:Mfer_0216    385 --------------------------------kklINNPES 393  Methanothermus fervidus DSM 2088
WP_023991716     415 --------------------------------dklENDPDS 423  Methanobacterium sp. MB1
O27400           404 --------------------------------kkvTENPAS 412  Methanothermobacter thermautotrophicus str. Delta H
O26770           416 --------------------------------aklKQDPTS 424  Methanothermobacter thermautotrophicus str. Delta H
NZAGRC:Abm4_1108 435 --------------------------------nriYKNPAS 443  Methanobrevibacter sp. AbM4
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