Conserved Protein Domain Family
Mntp

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pfam02659: Mntp 
Putative manganese efflux pump
MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defense against oxidative stress and as an enzyme cofactor.
Statistics
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PSSM-Id: 396982
Aligned: 63 rows
Threshold Bit Score: 109.107
Threshold Setting Gi: 158512405
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8XN03  30 RVKAKDALKVALFFGGFQALMPLIGWGAGRYFADYIKAFDHWIAFILLSFIGGKMIFEALKEDDEEKAEvavsmevsknk 109 Clostridium perfringe...
Q8RII2  31 SQKKQNFLKIVLTFGIFQFAMALVGSLSGILFIHYISLYSKYVSFAIFLFLGLMMLKEALKKEEMEYDE----------- 99  Fusobacterium nucleat...
Q97KG9  29 CVKRKNKLLFAISFGFFQFLCTFIGAYSGFLFNTYITYVPQIIGGMIIAFVGAFMIKEGFDNKEEKLLLn---------- 98  Clostridium acetobuty...
Q898D6  29 NVDLKYKSSCAIYFGFFQFLFAIIGGYAGFLFNKYIATMPQIVGGVVICIVGIIMIKEGIENEDSCKILk---------- 98  Clostridium tetani E88
Q814U5  31 pLKLRQILYIGMTIGIFHIIMPFIGMVLGRFLSEKYGDIAHFAGAILLIGLGFYIVYSTILQNEETRTAp---------- 100 Bacillus cereus ATCC ...
Q8EM65  32 QLRLKRIAYIGLTIGFLHMLMPLAGMLLGQVISEQIGQWTSFAGGVLLFLIGAHMFFSAFRLTEGFRWQp---------- 101 Oceanobacillus iheyen...
P39154  34 KLRKKQIFYIGFIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMSp---------- 103 Bacillus subtilis sub...
Q65DW1  35 KLKRNQVFQIGVIIGLFHVIMPLGGMIAGQFLSGALGALAGYIGGALLLVLGIQMIVASFNKSGEQIISp---------- 104 Bacillus licheniformi...
Q5WB61  29 KLSGKQIFRIGLTIGLFHVAMPLAGMAVGKWLSGHFDVIATYIGGGLLLVIGVQMALNAFSDHEAEGLKp---------- 98  Bacillus clausii KSM-K16
Q9K6F9  30 GLRFSQMFKVGLTIGVFHVIMPLMGMVAGKLLSAHLGLFANWLGAGLLLWLGLVMIVSPFQEKERTFVDp---------- 99  Bacillus halodurans C...
Q8XN03 110 erefanmkrkEELSAKNLTVLAIATSIDALAVGVS-FAFL--GI-SIVQTIIIIGIITFVLCFLGVIIGEKLGD--IFKN 183 Clostridium perfringe...
Q8RII2 100 ----------KYLDFKTLIIMGIATSLDALLVGLT-FSIL--PFyQTFLYTVEIGVITAIIAGLGFILGDKFGN--ILGQ 164 Fusobacterium nucleat...
Q97KG9  99 --------------FKMYFVLGISVSIDAAVVGFTmFNKIssNY-VILGDSVFIGIVTLILSIIAFIISRYLKRiqLVCK 163 Clostridium acetobuty...
Q898D6  99 --------------PGMNIILGISVSIDAMVVGFTaLNKIqsGL-LILRDTLFIGIVTLFVSILAFITSKYLKKidVIGK 163 Clostridium tetani E88
Q814U5 101 -------------IGISLFVFAFGVSIDSFSVGLS-LGIY--GA-QTIITILLFGFVSMLLAWIGLLIGRHAKD--MLGT 161 Bacillus cereus ATCC ...
Q8EM65 102 -------------vGVGLWIIAFSVSLDSFTVGLG-LGIS--GV-QIFVTLFAFGIVSCFLTWLGMLIGRKVYR--FLGV 162 Oceanobacillus iheyen...
P39154 104 -------------aGPGLLLFAIGVSLDSFSVGLS-LGIY--GS-HPLLTITLFGLFSMMLTWLGLLVGKQVQS--WLGT 164 Bacillus subtilis sub...
Q65DW1 105 -------------hGFGLFVFAVGVSLDSFSVGLS-LGLY--GT-KPILTIFLFGLFSMVLTWAGLLLGKKVQT--WLGA 165 Bacillus licheniformi...
Q5WB61  99 -------------aGWGLLLFAVGVSLDSFSAGLS-FGIL--GT-EMFVTVGMIGAMSMVMSWIGLIVGSHFQK--FLGA 159 Bacillus clausii KSM-K16
Q9K6F9 100 -------------sGIGLFVFALSVSLDSLSAGLS-LGMV--GA-KMALAVVAMGVMSTVLSWLGLFIGMRFQR--YVGP 160 Bacillus halodurans C...
Q8XN03 184 YAEIVGGVILILIGINIL 201 Clostridium perfringens str. 13
Q8RII2 165 KSHFLGAALLIFISINIL 182 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Q97KG9 164 YADYIGGIILVIFGLKMM 181 Clostridium acetobutylicum ATCC 824
Q898D6 164 YADYIGGIILIFFGLKMI 181 Clostridium tetani E88
Q814U5 162 YGEIVGGIILVGFGLYIL 179 Bacillus cereus ATCC 14579
Q8EM65 163 YSELLGGSILCGFGIFIL 180 Oceanobacillus iheyensis HTE831
P39154 165 YSEALGGIILIVFGLKLL 182 Bacillus subtilis subsp. subtilis str. 168
Q65DW1 166 YSEALGGAILLSFGLKLL 183 Bacillus licheniformis DSM 13 = ATCC 14580
Q5WB61 160 YGELLGGLVLIGFGLKIM 177 Bacillus clausii KSM-K16
Q9K6F9 161 YSELLGGFILCGFGVKLL 178 Bacillus halodurans C-125
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