Conserved Protein Domain Family
Mntp

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pfam02659: Mntp (485886 is an unknown moldel)
Putative manganese efflux pump
MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defense against oxidative stress and as an enzyme cofactor.
Statistics
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PSSM-Id: 485886
Aligned: 53 rows
Threshold Bit Score: 110.654
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8XN03        30 RVKAKDALKVALFFGGFQALMPLIGWGAGRYFADYIK-AFDHW---------IAFILLSFIGGKMIFEAL------KEDD 93  Clostridium per...
Q8RII2        31 SQKKQNFLKIVLTFGIFQFAMALVGSLSGILFIHYIS-LYSKY---------VSFAIFLFLGLMMLKEAL------KKEE 94  Fusobacterium n...
Q97KG9        29 CVKRKNKLLFAISFGFFQFLCTFIGAYSGFLFNTYIT-YVPQI---------IGGMIIAFVGAFMIKEGF------DNKE 92  Clostridium ace...
Q898D6        29 NVDLKYKSSCAIYFGFFQFLFAIIGGYAGFLFNKYIA-TMPQI---------VGGVVICIVGIIMIKEGI------ENED 92  Clostridium tet...
WP_015923513  28 QFKPSKIVEISAIIGLFHIIMPLTGYYGGHAIEELVTrYFWSYgqvdkffkiIGAGLLLLIGFYMIVEKW------LGRE 101 Halothermothrix...
Q24MM2         7 gvGKRMTLRLSLLVAVFHVFMPLGGLFLGQTLGMFLG-HLAKG---------IGALVLLWLGGRMIFHVW------RPEA 70  Desulfitobacter...
Q0AUC1        30 GVAKDYEKKFVLTVGILHVLMPLLGLNLGLVAGRFLG-VWATR---------LGALVLVYLGWQMLSKGYaeiqpqRYNF 99  Syntrophomonas ...
Q3A931        28 KIKRKEIIALSLTVLVYHIVMPILGWFAGDLTGRFLG-KVATY---------IGGAILIYLGYKMIRHGI------SQEE 91  Carboxydothermu...
A4J9B4        28 GVNRRQIALISLTVLIFHILMPLLGWYAGGFLGSKMG-QAASI---------AGALLLLYLGGKMIWDTI------KPGK 91  Desulforamulus ...
A5CYC0        28 GISRRRILQISATVLLFHIFMPLTGWLVGEFTGSLIG-RAAAV---------IGSLLLVGLGVKMIWAAW------RNGG 91  Pelotomaculum t...
Q8XN03        94 EEKAEVavsmevsknkerefanmkrkEELS-AKNLTVLAIATSIDALAVGVS-FAFL--GI-SIVQTIIIIGIITFVLCF 168 Clostridium per...
Q8RII2        95 MEYDE---------------------KYLD-FKTLIIMGIATSLDALLVGLT-FSIL--PFyQTFLYTVEIGVITAIIAG 149 Fusobacterium n...
Q97KG9        93 EKLLLN-------------------------FKMYFVLGISVSIDAAVVGFTmFNKIssNY-VILGDSVFIGIVTLILSI 146 Clostridium ace...
Q898D6        93 SCKILK-------------------------PGMNIILGISVSIDAMVVGFTaLNKIqsGL-LILRDTLFIGIVTLFVSI 146 Clostridium tet...
WP_015923513 102 QELKN---------------------FDLT-GWGIIALAISVSMDALSVGIS-LGMLdvGI----FAVVLFGGVATVMMA 154 Halothermothrix...
Q24MM2        71 EYIPLSkaranln------rrqlptgVSLS-GIGMYALAASVSLDALSVGFS-LGTV--DS-RIGLTVLVMGTVAGIMMG 139 Desulfitobacter...
Q0AUC1       100 AEAKTIlag--------------kqqSTLDsWTSILLLGLSVSIDALTVGFT-LGTL--KM-PILITVLIMGLIAASMSW 161 Syntrophomonas ...
Q3A931        92 ELPH----------------------VTYN-LVGLLLIGLSVSMDALSVGFT-LGTV--KV-NLWFVALITGIVAGVMTL 144 Carboxydothermu...
A4J9B4        92 DEGPRF--------------------VITN-TGGLLLLSASVSMDALSVGFT-LGTQ--QV-SLVLAAGVIGLVAGMMTF 146 Desulforamulus ...
A5CYC0        92 ETEPSL--------------------VRFN-FWGLLLLGASVSMDALSAGFT-LGTR--QV-NLLLAAGVIGLVAGAMTA 146 Pelotomaculum t...
Q8XN03       169 LGVIIGEKLGD--IFKNYAEIVGGVILILIGINIL 201 Clostridium perfringens str. 13
Q8RII2       150 LGFILGDKFGN--ILGQKSHFLGAALLIFISINIL 182 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Q97KG9       147 IAFIISRYLKRiqLVCKYADYIGGIILVIFGLKMM 181 Clostridium acetobutylicum ATCC 824
Q898D6       147 LAFITSKYLKKidVIGKYADYIGGIILIFFGLKMI 181 Clostridium tetani E88
WP_015923513 155 SGLSLGSKVGS--WIGDDTQVIGGLALIYLGLHFM 187 Halothermothrix orenii
Q24MM2       140 GGLVLGRYVGS--WLGKRAEIVGGFVLVIIGLRML 172 Desulfitobacterium hafniense Y51
Q0AUC1       162 VGFAGGRVLGR--LTGSYAQILGGVVLLALAIKFV 194 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
Q3A931       145 SGLLLGRRVSK--VLGERAQIVGGLILLLIAGKLI 177 Carboxydothermus hydrogenoformans Z-2901
A4J9B4       147 AGLTLGKYVGD--WIGERAELVGGIILVGIGVKLF 179 Desulforamulus reducens MI-1
A5CYC0       147 GGLVFGRFLGS--RVGERAQLLGGLILVGIGIKLF 179 Pelotomaculum thermopropionicum SI
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