Conserved Protein Domain Family
CobS

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pfam02654: CobS 
Cobalamin-5-phosphate synthase
This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyzes the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT.
Statistics
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PSSM-Id: 396978
Aligned: 622 rows
Threshold Bit Score: 49.8727
Threshold Setting Gi: 81626117
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8NNJ7            30 ALNWMTVLPVpgasvfdrttgAR---VMAS--L---PFVGFVFGMF----TAIIMWAIGpisgvihvdgLL-VAVLI-Va 95  Corynebacte...
WP_013336589      13 VITFFTVIPIggth---dvsrALrnaWLAV--IivpPITGLLPGLFgyylSLLTHndll-------iavIT--YMLL-L- 76  Vulcanisaet...
Q18KB3             9 GIGFLTRVPIghdkkawd------afrqtpvaF---TVIGYPLGTIvalpFVLLSI--------------------VpVp 59  Haloquadrat...
jgi:Calag_1123    11 LLSFLTTIPTn---------qNNikeASEY--FylsPLIGLIEGII----IGLIFFLLRfn-------fIInGSIL--La 66  Caldisphaer...
jgi:Igag_0327     10 LLSLLTTIPIg---------eEDiesGARV--FylvPLIGLLEGCIagaiLSLMKILQLs--------iDIiAVLY--Ia 68  Ignisphaera...
WP_014026878       7 LLALLTRLPVg---------yASldeVARC--LhlvPLVGLIEal----iVSLAFILLLgn-------pGIaAAVY--Lv 62  Pyrolobus f...
Q9YAA2             9 LASLLTALPLg---------gGSldeAARS--FylvPLLALAVGAAsaspSALAVEAGVgy-------iAg-GAVY--Tl 67  Aeropyrum p...
CBRAS:ASAC_0145    6 LLALFTRLPVg---------sGDleaAASS--FymvPIVGLAEGVIvs-lVGFAVSAVKpa-------pMLaAALM--Li 64  Acidilobus ...
jgi:Cmaq_0513      6 LISFLTIIPAg----------GKfeyAPRY--FylvPLIGLIEGLIaaspLLISKPIG-----------AAlSTALTyL- 61  Caldivirga ...
CBRAS:FFONT_0027   7 LLSFLTPIPVp---------rKYregGLSFgsVyllPIIGLLRGGIaiipAAVLLSLKIkl------vpLIaFSIVA--- 68  Fervidicocc...
Q8NNJ7            96 f--------weL---LNRFMHLDGLADVSDAL-GSy-aA-PPRAREILADPRTGLFGLATAMLSVLLQVAA---V----- 153 Corynebacte...
WP_013336589      77 -----------L---LTGLNHIDGFADVVDAL-MVr-gS-IEDRIRVLKDPHRGSASIAMVVLLVILAVSSlinL----- 134 Vulcanisaet...
Q18KB3            60 tligvylliliG---VTGITHIDGIADIGDAAvVHdtdDeHSRRRSVLHDSQVGVGGALAVTVTVVSLALGvlgAtrttp 136 Haloquadrat...
jgi:Calag_1123    67 s--------hlL---LTGGLNLDGFSDYSDVI-GSr-kI-GEEAEKILKDPRKGSFAIIFTSLIIIIRFASfsnI----- 127 Caldisphaer...
jgi:Igag_0327     69 i--------hiA---ITGGIHIDGYADYLDAI-GSh-rR-GEEALKIMKDPRKGTFSIAILTLSLITSYISmkeLitl-d 133 Ignisphaera...
WP_014026878      63 l--------hlL---VTGGLHLDGFADYVDAI-ASg-rR-GLEAVRVMKDPRRGSLAAAALAIHSILVYASastIasa-r 127 Pyrolobus f...
Q9YAA2            68 a--------yiL---LTGGIHMDGLADYSDVL-GSr-aS-GGEALRILKDPRKGAFAALALSLAIALSIVFpgeVlrlss 133 Aeropyrum p...
CBRAS:ASAC_0145   65 a--------hvA---VTGGLHLDGLADYSDVL-GSg-lR-GEEAVRVLKDPRKGSFAIMAVVVALVARLSAfyyLyrc-- 128 Acidilobus ...
jgi:Cmaq_0513     62 ---------------INGFQHMDGFLDFGEALlTGr--R-GEEAVRVLKDPHRGSFALTLGLIDVLLVYSSllsMgketl 123 Caldivirga ...
CBRAS:FFONT_0027  69 -----------LhfiMQGFLHADGFIDFTEALlAGrf---gvDAKKVLKDKYRGSYAIASFSVFTLWLYSSlssFqepgy 134 Fervidicocc...
Q8NNJ7           154 --ASLvdstvwwmICfiPVLGRIAGQVTALKNHNAfsP--TG-FGALVIgtvkfwwialwllvtaalafwcaelisplsp 228 Corynebacte...
WP_013336589     135 --Ihvl----wqsLLiaEFVSKSSCCLCGVIGKRPs-H--KG-LGWQLTtyskekvhiiiavl----------------- 187 Vulcanisaet...
Q18KB3           137 qvt-------filvltaEVGAKSAMALLVCTGD----AahDG-LGAALIdest--------------------------- 177 Haloquadrat...
jgi:Calag_1123   128 --KNIf-------SIvlSYVTGIESGYLISYFSNA--PkyQG-LGSMFIessknkkkllyn------------------- 176 Caldisphaer...
jgi:Igag_0327    134 lyELIp-------LLisIYVSATESMYIVAAIGRE--EpyMG-LGYMFSryakplkniimn------------------- 184 Ignisphaera...
WP_014026878     128 leTILa-------AMisSYTVACYTMVYLLAFTRP--EpyAG-MARALQeaapksit----------------------- 174 Pyrolobus f...
Q9YAA2           134 pgAFIi-------LAasSHSGAAASMYMLLAAGPP--EpyRG-MARAFSleargrvalfaa------------------- 184 Aeropyrum p...
CBRAS:ASAC_0145  129 -----------paIIvaAYASSLEASFVAARAGVQ--EpyEG-MASRFEraardgrqllln------------------- 175 Acidilobus ...
jgi:Cmaq_0513    124 itLPI------------TEAAAAYVMFTTAYLG----KpsEGgLGRLFIieak--------------------------- 160 Caldivirga ...
CBRAS:FFONT_0027 135 alILFpi--------saEVWSPSSMILTSLLSG----EppEG-MGREFKrsss--------------------------- 174 Fervidicocc...
Q8NNJ7           229 ltsvntpfvagpfpaainpawlggwV--AI----T--AV-----------------VACVF----AALFSRRLSRS-FGG 278 Corynebacte...
WP_013336589     188 -----------iialiitylllkliG--LL-------VA-----------------LITMA----FNTLLFIALQNnLGG 226 Vulcanisaet...
Q18KB3           178 -------------------------plsLFpvilAltPLllaipy-----lgasptAAVVLtpliVALVIKQWADNaLGG 227 Haloquadrat...
jgi:Calag_1123   177 ---------------------------liiyliiiiilLfvsktk-----yylisiFSLLL----VPIIVFDSNKR-LGY 219 Caldisphaer...
jgi:Igag_0327    185 -----------------iaiyvllilllLAin----mKIllhll--------aivvLTIAI----SLLSYRDSRYR-IGF 230 Ignisphaera...
WP_014026878     175 ---------------------ramivtiACia----lAAlldpla-----tatavvTGIVT----GEFVRRDVEKR-VGF 219 Pyrolobus f...
Q9YAA2           185 ----------------tstasatassaaLAlygyPwwLVplq------------wlsSLAT----GVWVLRSARST-LGY 231 Aeropyrum p...
CBRAS:ASAC_0145  176 ---------------------------altyiaimtaiAvlrpls-------ligaaALLA----GFLLAADANSR-LGF 216 Acidilobus ...
jgi:Cmaq_0513    161 ---------------------gnvkLtsSTllyaAiiVAvpllyhwgaliilititVNALIselvALLTVKLSHSR-LGF 218 Caldivirga ...
CBRAS:FFONT_0027 175 ----------------------pssLaaSLlisfPftLMlsfslk-----lsliitALSLSslllSSLLSYYMGKKaLGY 227 Fervidicocc...
Q8NNJ7           279 LNGDCIGACIHLGASISAV 297 Corynebacterium glutamicum ATCC 13032
WP_013336589     227 AVGDLYGFTLEVSRVTALV 245 Vulcanisaeta distributa
Q18KB3           228 ISGDVLGAVNEVSRAAAih 246 Haloquadratum walsbyi DSM 16790
jgi:Calag_1123   220 ANGDVIGFTIEIIETASLL 238 Caldisphaera lagunensis DSM 15908
jgi:Igag_0327    231 ITGDVMGFTYELLRILSLL 249 Ignisphaera aggregans DSM 17230
WP_014026878     220 STGDTAGFTYETVRAVALL 238 Pyrolobus fumarii
Q9YAA2           232 VNGDVAGFCFEASRIASIV 250 Aeropyrum pernix
CBRAS:ASAC_0145  217 VNGDVMGASIEVGGVVALV 235 Acidilobus saccharovorans 345-15
jgi:Cmaq_0513    219 VNGDVLGFSFELSKVTLLt 237 Caldivirga maquilingensis IC-167
CBRAS:FFONT_0027 228 ANGDVLGFSNELCYALLLT 246 Fervidicoccus fontis Kam940
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