Conserved Protein Domain Family
CobS
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pfam02654: CobS (This model is not part of the current CDD release)
Cobalamin-5-phosphate synthase
This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyzes the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT.
Links
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Statistics
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PSSM-Id: 515082
Aligned: 504 rows
Threshold Bit Score: 52.5597
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8NNJ7         30 ALNWMTVLPVpgasv------fdrttG-------AR---VMAS--L---PFVGFVFGMF----TAIIMWAIgpisgvihv 84  Corynebacteriu...
WP_015409413   13 GVAFLTRVPVgsneadwd-rfrsfpaA------------------F---SLVGYPIGAVaalpFLSG------------- 57  Natronomonas m...
WP_013336589   13 VITFFTVIPI----------------GgthdvsrALrnaWLAV--IivpPITGLLPGLFgyylSLLTHndll-------i 67  Vulcanisaeta d...
Q8TUT2          9 VFRFLTVLPIgehpkspreigeqawlG------------------L---PAVGLVSGLLagvvAWAFAG----------- 56  Methanopyrus k...
WP_015232742   11 LLSFLTTIPTn----------------------qNNikeASEY--FylsPLIGLIEGII----IGLIFFLLrf------- 55  Caldisphaera l...
jgi:Igag_0327  10 LLSLLTTIPIg----------------------eEDiesGARV--FylvPLIGLLEGCIagaiLSLMKILQls------- 58 
WP_244403920    4 LLALLTRLPVg----------------------yASldeVARC--LhlvPLVGLIEal----iVSLAFILLlg------- 48  Pyrolobus fumarii
WP_013266065    6 LLALFTRLPVg----------------------sGDleaAASS--FymvPIVGLAEGVIvs-lVGFAVSAVkp------- 53  Acidilobus sac...
jgi:Cmaq_0513   6 LISFLTIIPAg-----------------------GKfeyAPRY--FylvPLIGLIEGLIaaspLLISKPIG--------- 51 
WP_014557172    7 LLSFLTPIPVp----------------------rKYregGLSFgsVyllPIIGLLRGGIaiipAAVLLSLKikl------ 58  Fervidicoccus ...

Q8NNJ7         85 dgLL-VAVLI-V--AFW---E---L---LNRFMHLDGLADVSDAL-GS-YAA-PPRAREILADPRTGLFGLATAMLSVLL 148 Corynebacteriu...
WP_015409413   58 ---------LsAptVAFgylLalvA---VVGIPHFDGVADLGDAVaAHg----AGDARAALKDTATGVGAIVAIAVVVGG 121 Natronomonas m...
WP_013336589   68 avIT--YMLL-L------------L---LTGLNHIDGFADVVDAL-MVr-GS-IEDRIRVLKDPHRGSASIAMVVLLVIL 126 Vulcanisaeta d...
Q8TUT2         57 --TPvRGCLVvL------------TllvLEGAQHFDGLVDVGDALmAGv--IsEEGATKAMRDPRVGVGGLAIGSMALLL 120 Methanopyrus k...
WP_015232742   56 nfIInGSIL--L--------AshlL---LTGGLNLDGFSDYSDVI-GSr-KI-GEEAEKILKDPRKGSFAIIFTSLIIII 119 Caldisphaera l...
jgi:Igag_0327  59 -iDIiAVLY--I--------AihiA---ITGGIHIDGYADYLDAI-GSh-RR-GEEALKIMKDPRKGTFSIAILTLSLIT 121
WP_244403920   49 npGIaAAVY--L--------VlhlL---VTGGLHLDGFADYVDAI-ASg-RR-GLEAVRVMKDPRRGSLAAAALAIHSIL 112 Pyrolobus fumarii
WP_013266065   54 apMLaAALM--L--------IahvA---VTGGLHLDGLADYSDVL-GSg-LR-GEEAVRVLKDPRKGSFAIMAVVVALVA 117 Acidilobus sac...
jgi:Cmaq_0513  52 --AAlSTALTyL----------------INGFQHMDGFLDFGEALlTGr--R-GEEAVRVLKDPHRGSFALTLGLIDVLL 110
WP_014557172   59 vpLIaFSIVA--------------LhfiMQGFLHADGFIDFTEALlAGrFg---vDAKKVLKDKYRGSYAIASFSVFTLW 121 Fervidicoccus ...

Q8NNJ7        149 QVAA---V-------ASLVDStvwwmICFIPVLGRIAGQVTALKNH-----NAfsPt--G-FGALVIG-TVKFwwialwL 209 Corynebacteriu...
WP_015409413  122 LVLGalgLagapprta-------vgivvaaEVGAKLGMASVACLAS---------AaheG-LGSAFTErAEPVlll---- 180 Natronomonas m...
WP_013336589  127 AVSSlinL-------Ihvl----wqsLLiaEFVSKSSCCLCGVIGK-----RPs-Hk--G-LGWQLTTySKEK------V 180 Vulcanisaeta d...
Q8TUT2        121 AVASfgwIpfevlvpI--------------EVFSR-FTVLPMAAVGepapaSY--------SGRVFTeyvdadq------ 171 Methanopyrus k...
WP_015232742  120 RFASfsnI-------KNIF-------SIVLSYVTGIESGYLISYFS-----NA--PkyqG-LGSMFIEsSKNK------K 171 Caldisphaera l...
jgi:Igag_0327 122 SYISmkeLitl-dlyELIP-------LLISIYVSATESMYIVAAIG-----RE--EpymG-LGYMFSRyAKPL------K 179
WP_244403920  113 VYASastIasa-rleTILA-------AMISSYTVACYTMVYLLAFT-----RP--EpyaG-MARALQEaAPKsitr---- 172 Pyrolobus fumarii
WP_013266065  118 RLSAfyyLyr------cpA-------IIVAAYASSLEASFVAARAG-----VQ--EpyeG-MASRFERaARDG------R 170 Acidilobus sac...
jgi:Cmaq_0513 111 VYSSllsMgketlitLPI------------TEAAAAYVMFTTAYLG---------KpseGgLGRLFIieakgnvkl---- 165
WP_014557172  122 LYSSlssFqepgyalILFPISa--------EVWSPSSMILTSLLSG---------EppeG-MGREFKrssspssl----- 178 Fervidicoccus ...

Q8NNJ7        210 Lvta-------alAFWCaelisplspltsvntpfvagpfpaainpawlggwvaiT--AV-----------------VACV 263 Corynebacteriu...
WP_015409413  181 ----------------------------------------------------gpAlaALpaallv-----gpvragIAAV 203 Natronomonas m...
WP_013336589  181 hii--------iaVLIIaliityll-------------------------lkligllVA-----------------LITM 210 Vulcanisaeta d...
Q8TUT2        172 ------------------------------------------------vllggiLstVVslpfs--------pvatLTCA 195 Methanopyrus k...
WP_015232742  172 KllynliiyliiiIIL------------------------------------------Lfvsktk-----yylisiFSLL 204 Caldisphaera l...
jgi:Igag_0327 180 NiimniaiyvlliLLLlai------------------------------------nmKIllhll--------aivvLTIA 215
WP_244403920  173 ----------amiVTIaci------------------------------------alAAlldpla-----tatavvTGIV 201 Pyrolobus fumarii
WP_013266065  171 QlllnaltyiaimTAI------------------------------------------Avlrpls-------ligaaALL 201 Acidilobus sac...
jgi:Cmaq_0513 166 ----------------------------------------------tsstllyaAiiVAvpllyhwgaliilititVNAL 199
WP_014557172  179 ----------------------------------------------aasllisfPftLMlsfslk-----lsliitALSL 207 Fervidicoccus ...

Q8NNJ7        264 F----AAlFsrrLSRS-FGGLNGDCIGACIHLGASISAV 297 Corynebacterium glutamicum ATCC 13032
WP_015409413  204 AagplVAvGlirWADGtLGGVNGDVFGATNELARVLGLh 242 Natronomonas moolapensis
WP_013336589  211 A----FNtLlfiALQNnLGGAVGDLYGFTLEVSRVTALV 245 Vulcanisaeta distributa
Q8TUT2        196 VcsavVAwTcleAARRtIRGVNGDFLGASIWVSRVLSAV 234 Methanopyrus kandleri AV19
WP_015232742  205 L----VPiIvfdSNKR-LGYANGDVIGFTIEIIETASLL 238 Caldisphaera lagunensis
jgi:Igag_0327 216 I----SLlSyrdSRYR-IGFITGDVMGFTYELLRILSLL 249
WP_244403920  202 T----GEfVrrdVEKR-VGFSTGDTAGFTYETVRAVALL 235 Pyrolobus fumarii
WP_013266065  202 A----GFlLaadANSR-LGFVNGDVMGASIEVGGVVALV 235 Acidilobus saccharovorans
jgi:Cmaq_0513 200 IselvALlTvklSHSR-LGFVNGDVLGFSFELSKVTLLt 237
WP_014557172  208 SslllSSlLsyyMGKKaLGYANGDVLGFSNELCYALLLT 246 Fervidicoccus fontis
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