2R5R


Conserved Protein Domain Family
GCHY-1

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pfam02649: GCHY-1 
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Type I GTP cyclohydrolase folE2
This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens. The invariate, highly conserved glutamate residue at position 216 in Neisseria gonorrhoeae FolE2 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent.
Statistics
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PSSM-Id: 396975
Aligned: 216 rows
Threshold Bit Score: 177.306
Threshold Setting Gi: 296925202
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2R5R_A            13 ADVQGSLDTrhIAIDRVGIKAIRHPVVVADK-GGGsQHTVAQFNXYVN------LPHNFKGTHXSRFVEILNsherEIS- 84  Nitrosomona...
BAJ50763           5 rDVQSEPAAtpIELDWVAVSDVLFPVDEEFlegYRl-ASTPVVEAAVN------LPQTQRGIHASRTYEAVKq---GISg 74  Candidatus ...
Q5JH75             3 vETQEEVPEirEPLRRVGITNLRTVAKINWK-GREy-TFLPLIEVTID------VPAEKKGIHMSRLVESITe---AMS- 70  Thermococcu...
Q8TZZ2             3 iETQEEPPEikVYLPRVGITNLKSVAKIEWK-GRIy-TFIPTFEVAID------LPEEKKGIHMSRLVESITe---TMS- 70  Pyrococcus ...
Q9HJ35             5 LDVQKETPRirIAIDRVGVKNIKFPLKIHDD-FAFl-TL----NLFVD------VPADRKGADMSRAVESIQk---VIN- 68  Thermoplasm...
Q6L0A8             5 KDVQGFRPDyeIPIKRAGIKSFKRRVKLNYN-N-------ESFDSYVDvsisvsLNPDRKGLDMSRTIESVRs------- 69  Picrophilus...
CBRAS:FFONT_0386   6 PDIHENPPEykIAINKAGIEGLKKKIKIKIG-Ns-cSEKLCTINLYID------LDKELRGVHLSRLVNSLNq---ELNs 74  Fervidicocc...
jgi:Igag_0283      1 mELQDKEPTisIDIEMLGFKNVRRKLVLRTD-KGSi-ALDADISLYVD------VDSSRRGVHLSRTAEALLe---VIEe 69  Ignisphaera...
Q9Y9I0             1 mDVQDLKPPkpLYLERVGFRGVRRRALLETP-EGPv-TLDLELDVFVD------LDRSKRGVHLSRNIEAVEa---VVSe 69  Aeropyrum p...
jgi:Calag_0295     4 LEIQDMKPNytIPIKRVGFKGLWKRAYIESP-LGVm-PIDLEINAYVE------IPEDKKGAHLSRNVEALPe---DMEf 72  Caldisphaer...
2R5R_A            85 -V----------ESFEE----ILRSXVSRLE-SDSGHIEXAF-PYFINKSAPVSGvK-SLLDYEVTFIGEIkhg---nqY 143 Nitrosomona...
BAJ50763          75 lKy---------RDVYGitaqIVKTLLEKHVySTRAKAVLRL-SLFEVERTPVTKsE-SMEYFDAVFKSYAhrvngglvL 143 Candidatus ...
Q5JH75            71 -EaveeevakvhSSLEElgksVIERLEGKHPh-KRAEVWIKT-HLIIPRTTPASKkT-SYEPYDVEVGVIKned---gsF 143 Thermococcu...
Q8TZZ2            71 -EaveeevkkvhTSLEDlalcIIRRIEKKHSh-KRAEVWIKS-TLILERQTPASGkT-SYEPYDVEVGVIKnsd---gsI 143 Pyrococcus ...
Q9HJ35            69 -Ags------ygERIGDigiaICDEALSRFNySEKAQCEVNI-QYY-----RRSGeR--YLEYRMYVETAKdrk---qiM 130 Thermoplasm...
Q6L0A8            70 -S----------YNLNDvaydIYNDLFSRINySSSGYVNVSFdFYYNNKIYPVS----------LIAEGDKn------dV 122 Picrophilus...
CBRAS:FFONT_0386  75 nEc---------FKLNDllekTAKRVLNTHFsSSRSEIHVSF--------------EdIIEDTRFVLHASYvrek-ngsQ 130 Fervidicocc...
jgi:Igag_0283     70 rYe--------aKTIEEyldaMALKLLEKHEyIKRAIVNAKL-TYYIEIEY--HGiR-GLEPIEIEVEVERlrn---geR 134 Ignisphaera...
Q9Y9I0            70 r---------raRSIEGllrsIAKELLSRHGyAEKATVRART-RYYIDLEA--AGvK-GREPVDVAVTVSLtrs---ggE 133 Aeropyrum p...
jgi:Calag_0295    73 pTk--------aKSIEYylekIHNSLLRLHSyAKTARVEAKT-RYGVEIKF--NDlS-EMEPVDVLISVDGdl----nhK 136 Caldisphaer...
2R5R_A           144 SFTXKVIVPVTSLCPCSKKIS------------------DYgAHNQRSHVTISVRtn---sfIWIEDIIRIA---EEQAS 199 Nitrosomona...
BAJ50763         144 RNLVGVRGVGITACPCAKEVIrevyln------gdghkePIpTHIQRAYAEIVVEsd---gnVTISQLLNIL---KESFS 211 Candidatus ...
Q5JH75           144 EKVLRVRVIGNTACPHAMANNng------------------kTHIQRAIGELEIRapf-eeeIPLEEMIDVV---ESSFS 201 Thermococcu...
Q8TZZ2           144 KKVLKVKVIGNTACPHAMANNqg------------------kTHIQRAIAELEIEthf-nedIALEDMIEVV---ESSFS 201 Pyrococcus ...
Q9HJ35           131 KNEIGISYVTMTACPCAMETTralismdnpdisdaisaiPTiTHNQRNVTKLTVDnrs--kmITVWDLADVM---ERVQG 205 Thermoplasm...
Q6L0A8           123 KRYVEVSAEGMTVCPCAMETIrsimlydyn----vsygdigiSHNQRNKASLKIQyi---kdAHLERLIDIL---ESSFS 192 Picrophilus...
CBRAS:FFONT_0386 131 EGKVSIELNGITSCPCAKEVFkfyen---------teyeKTpTHMQRAELHITLNskynldlLYNEYLLKAIsvgKSSFS 201 Fervidicocc...
jgi:Igag_0283    135 FWKLSVGVKGITVCPSAKESIasmln---------qnieIApSHMQRVVLKGRIIsrg--nfIGIEKIARTL---FNSVS 200 Ignisphaera...
Q9Y9I0           134 RWRVAVSVKGMTVCPSAQSTIaeaeg--------isdpsRApSHSQKVLLKGTVDtgk--vmVRIEDLARAL---LQSFS 200 Aeropyrum p...
jgi:Calag_0295   137 RWSITVGLYGMTACPSAQSTIssii----------nsntISpSHSQKVLLYGTIEtee-nyiIRIEDIARCL---SNAFS 202 Caldisphaer...
2R5R_A           200 CELYGLLKRPDEKYVTERAYNNPKFVEDIVRDVAEVLnhddrIDa---------yIVESENFESIHNHSAYA 262 Nitrosomonas europa...
BAJ50763         212 SRTIELLKRLDEAEVVVSAIQRPRFVEDVARTAAYLV-----VKqfpklpnshqvSIRVKSLESIHRHNmes 278 Candidatus Caldiarc...
Q5JH75           202 HPTYTLLKTVDENAVVQGMFANPKFVEDVAREIFAKA-----KErfr-----griHVRVISNESIHKHDVIA 263 Thermococcus kodaka...
Q8TZZ2           202 SPTYTLLKTPDENAVVRRMYENPKFVEDVAREIVYKA-----RNrfk-----gkiHVKVISHESIHKHDVIA 263 Pyrococcus furiosus...
Q9HJ35           206 KPLDSLLKRVEEGRLVYSAHRNPKFVEDVVREIAYEA-----ARvlgvp-deatiKVSSESDESIHPHNAYA 271 Thermoplasma acidop...
Q6L0A8           193 YPVRNMLKRYDEGKMIIEAHKRPKFVEDVVREIAYKA-----Afmepe--mnlymDVRSESFESIHPHNAYA 257 Picrophilus torridu...
CBRAS:FFONT_0386 202 DILKETLNRDEEYEFIKKTINNPMFAEDVCRKAYFYLkkelp--------sdiglKIKVISYESIHPYNVIA 265 Fervidicoccus fonti...
jgi:Igag_0283    201 APTFTLLKRTQEAKLVLEAHKKPMFIEDVVREAIWNI-----GKeiksfdkqtiiEVEVESYESIHPHNLYA 267 Ignisphaera aggrega...
Q9Y9I0           201 APTFTLLKKPQEARLILEAFTRPMFVEDVVREAAWRI-----Aaipyip-geallQVEAVSLESIHPHDLVA 266 Aeropyrum pernix K1
jgi:Calag_0295   203 APSFTLLKRMQEANLVISAHKNPKFVEDVVRDAIGGL-----RClteslpentviKAEAISLESIHPHNVYA 269 Caldisphaera lagune...
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