2R5R


Conserved Protein Domain Family
GCHY-1
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pfam02649: GCHY-1 (This model is not part of the current CDD release)
Type I GTP cyclohydrolase folE2
This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens. The invariate, highly conserved glutamate residue at position 216 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent.
Links
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Statistics
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PSSM-Id: 515080
Aligned: 183 rows
Threshold Bit Score: 177.321
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2R5R_A         14 DVQGSLDTRHIAIDRVGIKAIRHPVVVADKGGGSQHTVAQFNXYVNLPHNFKGTHXSRFVEILNsheREIS--V------ 85  Nitrosomonas e...
EQB67133        6 DVQKEKPDHHIAVSKVGIKGLELPIDIERNGSRN-HLIARFDLFVDIPSERKGADISRTVEIIE---ETIR--Ekp---v 76 
EQB72366        6 DVQAEKPKISIPITSVGLKGITYPVRVSRDNREI-DLLTRIDIYVDLPADRKGADFSRKIEAIN---EIIL--Eng---v 76 
WP_015319657    7 DVQASSPDVTVGLSQVGVTGVEKLVKIAREDKRPIVLTAEFEVFVDLPSWRKGADMSRNMEVID---EILE--Datr-de 80  Natronococcus ...
Q5UXK3          7 DVQASSPDVTVGLNRVGVTGVEKLVKLGRRDRDPIVLMAEFEVFVDLPSWRKGADMSRNMEVID---ETLE--Tavs-ee 80  Haloarcula mar...
WP_020447640    7 DVQADRPDVQVGLNRVGVTGVEKLVKIARPDDRPIVLMAEFEVFVDLPSWRKGADMSRNMEVVD---ETLE--Aatr-de 80  Salinarchaeum ...
Q3IR95          7 DVQASSPDVSVGLSRVGVTGVEKLVKLHRPNDRPIVLMAEFDVFVDLPSWRKGADMSRNMEVVD---EMLE--Eavs-ep 80  Natronomonas p...
jgi:Mfer_0397   7 DTQNELPKIPISLTRVGVTGVKKLVKIERKNKRPIIMLPVFNAFVDLPSSKRGIHMSRNPEAIS---EVIE--Eavn-gi 80 
Q8TY21          7 DVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGIHMSRSHEVLQ---EVLEelEmsvegs 83  Methanopyrus k...
D4GWJ7          7 DVQASQPDVTVGLSQVGVTGVEKLVKIARDGKRPLVLMAEFEVFVDLPGGRKGIDMSRNMQVID---EVLE--Aavs-ep 80  Haloferax volc...

2R5R_A         86 -ESFEE----ILRSXVSRLE-SDSGHIEXAFPYFINKSAPVSGVK-SLLDYEVTFIGEIkhG--Nq-YSFTXKVIVPVTS 155 Nitrosomonas e...
EQB67133       77 sDGIENlsmqLARKALDRFEySNVARSFIDADFF--MKIPQGKERtTTVKYNIFGNAVAr---rDgtEEKFVGVKVLGMN 151
EQB72366       77 vPSIEDlslrIAEKVLQKLPySTQCRVTVSADYMREKKSKNGNSR-IIVPYKLEGESVLr---rNgeSHKMVGVNVTGLN 152
WP_015319657   81 aYRVEEvcgeVAERLLGKHDyTSRAEVTMEAEFMRREQTPASDRE-TQHTVDIIASATAt---eEg-TREEIGAEVVGMT 155 Natronococcus ...
Q5UXK3         81 aYRVEDvcgdAAELLLEKHDyTTKAEVRMEAEYVTHESTPASEMA-TQSTADIIASATAt---eDg-TSEEIGARVTGMT 155 Haloarcula mar...
WP_020447640   81 vYGIENvcteAARRLLEKHDyTSKAEVSMEAEFVQREDTPASERE-TQFVSDVLARATAs---dEg-VRTEIGAEVTGMT 155 Salinarchaeum ...
Q3IR95         81 aLSVEDvcgdVAERLIEKHDyTTQAEVRMEAEYMIREETPATDRP-TQATADIIASATAd---eDgnTREEIGCHVVGMT 156 Natronomonas p...
jgi:Mfer_0397  81 nIELESlcakIASLLLKKHKyAQRAEVNMESDFAIVRRTPVTNNK-SQEMVKIIANAVGfrNgnDvkIRKMIGAEVTGIT 159
Q8TY21         84 dTVIEDlcsrISRRLLERHDyATRSEVYMTGELILSRRTPVTKLP-TQEPYKIIGRAVSkrTdnGieTRKMVGAEVVGLT 162 Methanopyrus k...
D4GWJ7         81 aYRVEDmcgdAAERLLAKHEyTTTAEVSMTAELVVREDTPASGLS-TQSTAEIIASATAt---dEg-TREEIGAEVVGMT 155 Haloferax volc...

2R5R_A        156 LCPCSKKIS------------------------------------DYgAHNQRSHVTISVRtn--sfIWIEDIIRIAEEQ 197 Nitrosomonas e...
EQB67133      152 ACPCAMETArailaerip------------------esssvlnkiPViTHNQRNRITLKIEvpegksVEAIDLIDIINST 213
EQB72366      153 ACPCAMETTralisrdfp------------------gndqilnriPSiTHNQRNHVRLMVQapagrsIEADDLIGICEKV 214
WP_015319657  156 VCPCSQGMSaarakqtledlgv-----------eeetitefleevPQpGHSQRGHATLTIEssgdpdVDLNDVIDIARDS 224 Natronococcus ...
Q5UXK3        156 VCPCSQGMSasraretlkqlnv-----------eddvieefletnPQaGHSQRGHATLTVQsdgapeVDLNELIEVARDS 224 Haloarcula mar...
WP_020447640  156 VCPCSQGMSeararetledldv-----------dddtveafldevPQpGHSQRGHATLTVEsdgvpeVDLVDLIDVARDS 224 Salinarchaeum ...
Q3IR95        157 VCPCSQGMSesrardvlegldv-----------drdtidafleevPQpGHSQRGHATLTVEtsgdpdVDLRTLIDIARDS 225 Natronomonas p...
jgi:Mfer_0397 160 VCPCAQELLkelnkqrllkfl------------dentvekvmknvTVaSHNQRSRGTIMIEvpenyeVRGEDIIEIIESS 227
Q8TY21        163 ACPCALEMMrehgkervkhrlmeeldleeeeaedlakkivredvhPM-THNQRGVGTILIEvsdvhrVSINDIIEIIEES 241 Methanopyrus k...
D4GWJ7        156 VCPCSQGMSasrardvlqdlav-----------dddtieefldkvPQpGHSQRGHATLTVEtqgspeVDLMDLIDIARDS 224 Haloferax volc...

2R5R_A        198 ASCELYGLLKRPDEKYVTERAYNNPKFVEDIVRDVAEVLnhddrIDAY---------IVESENFESIHNHSAYA 262 Nitrosomonas europae...
EQB67133      214 VESPLLPMLKRMGEGELVVRVHSRPMFVEDIVREVAIKV-----REKYkdfpkntrySVISESEESIHPHNAYA 282
EQB72366      215 LGGSLHSLLKRIDEGELVYNAHKNPKFVEDIVRDIAAEI-----LPRYsdfpdgtrvIVSSESEESIHPHNAYA 283
WP_015319657  225 MSARIYNLAKRPDEDHMTYAAHADAKFVEDCVRSMAEGV-----AEEFdhlpddavvTMKQSNDESIHQHNAHA 293 Natronococcus occultus
Q5UXK3        225 MSARIYNLAKRPDEDHMTYEAHKDAKFVEDCVRALAEGV-----VNTFpdlpddavvTMKQSNDESIHQHNAHA 293 Haloarcula marismort...
WP_020447640  225 MSARIYNLAKRPDEDHMTFDAHSDAKFVEDCVRSMAEGV-----VRTFpdlpddavvTMRQSNDESIHQHNAHA 293 Salinarchaeum sp. Ha...
Q3IR95        226 MSARIYNLAKRPDEDHMTFESHSDAKFVEDCVRSMANGL-----LEEYpdlpddtivRMEQSNDESIHQHNAHA 294 Natronomonas pharaon...
jgi:Mfer_0397 228 MSSPVYELLKRPDESKVVEMAHKKPMFVEDSVREMLYKI-----VEKFsylpdntivTVRQVNEESIHQHNAFA 296
Q8TY21        242 MSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRI-----VERFdylpddavvIVRQVNKESIHKHDAFA 310 Methanopyrus kandler...
D4GWJ7        225 MSARIYNLAKRPDEDHMTYHAHANAKFVEDCVRSMAELS-----LEALdhlgddavvHMKQSNDESIHQHNAHA 293 Haloferax volcanii DS2
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