pfam02643: DUF192 (This model is not part of the current CDD release)
Uncharacterized ACR, COG1430
Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologues are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for Saro_0823, a homologue of Thermotoga maritima TM1668, The homologue in Caulobacter crescentus (CC1388), is associated with CspD, a cold shock protein (CC1387). However, the genomic context of Novosphingobium aromaticivorans DUF192 domain-containing protein is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821 is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a.
Jiyao W et al.(2023). "The conserved domain database in 2023.",