5ZZW


Conserved Protein Domain Family
Methyltransf_28

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pfam02636: Methyltransf_28 
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Putative S-adenosyl-L-methionine-dependent methyltransferase
This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase. In eukaryotes it plays a role in mitochondrial complex I activity.
Statistics
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PSSM-Id: 396968
Aligned: 75 rows
Threshold Bit Score: 140.476
Threshold Setting Gi: 145341242
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZZW_B        76 MIGIWCVATWEAM---GKPK----K-LQIVEMGPGRGTLMKDILRSTKVF-K-EFYDSISVHLVEASPANKKTQKQNLLY 145 Dictyostelium d...
P36052        91 CLAKWLLVNYKLN---DYPYyd-lNiVNIYTDLPQAIQICKNLMSYLKSTlSdNMFQKIKYFMVPLY-KCDKIPSKLLDG 165 Saccharomyces c...
Q4CY00       249 VLAEYLVTMMRAKfd-------prEpLVVYDIGAGTGALAVSVLDYLAEHfS-AVYAQCEYHVVEQNPQLVQVLRNRLIT 320 Trypanosoma cruzi
XP_001415722 131 ALVRYVLETHRGD----CGDdealEpLRVYEIGGGAGTFASGFLDAVKREaP-KVYEKMRYTSIDISKRLCDDQLNRVRR 205 Ostreococcus lu...
A0BQV8        73 TLGNYINQQFRFTr---------kEkLRIVEIGAGYGAACEGVLYYMRNHqP-QTFSNMEYHLVDISPEACAQAQIRLSQ 142 Paramecium tetr...
EDO03707      84 AIARYLVNNYKIWqy-------pyHdLIIYEMGAGNGTLMLNILDYIRLTeP-EVYARTKFKIIEISSNLASLQKSHLLR 155 Sclerotinia scl...
Q5APE5       199 ALARYILVNYKLNvy-------pyNdLIIYEMGGGNGTLMCDILNYIRKHqP-EIYEKTQYKIIEISSQLASKQMKNALD 270 Candida albicans
Q6C0X9       202 ALARYLLVNYKLSly-------pyKdLIIYEMGGGNGTLMTNILDYIRDTqP-EVYERTRYKVIEISDQLAHKQQSALHT 273 Yarrowia lipoly...
Q7VBT2        67 LLASQVVDWVEALlhtDVTS----EvISIIDIGPGEGDLLFHLIEALQKKsP-SLFKKIKLILIEINEGMKDRQKRRLAP 141 Prochlorococcus...
Q7V7S2        67 LLAIQLVDWFQQL---QQ-RvdkgKsLSLIEVGPGEGDLSADLISALEDLcP-ALIPRLELVLVESNKAMALRQRERLKS 141 Prochlorococcus...
5ZZW_B       146 Fkdkainfd--hktigetPNGIKvtW--VG-KLEEVPtdIPTLFLAQEFFDALPIHVFRFSREKndW-CEVLVDEDIte- 218 Dictyostelium d...
P36052       166 Ipgsv---------slvqDYPVSpyF--LQ-KKFHIEd-PIQILMLNDVIKYTTHDLVRYSSDDkgW-QQCFVDINKng- 230 Saccharomyces c...
Q4CY00       321 Hyhhvk--------ihniSILN---WrqLE---R-----RRCVLLGVELLSGMPHDCVLLSGDG--VcNEHWFGFQQhdn 379 Trypanosoma cruzi
XP_001415722 206 Sghandvhd--atvgdatSLQT---WgaTN---E-----ETCFVIALEVLDNLPHDRVWRPKRG--EgEWMQTEIVRnlt 270 Ostreococcus lu...
A0BQV8       143 Dfkqqikkg--nlrifnqDFLN---YkqHTqNN------EMWFFVFLEVFDNLAHDKVI---DG----KQVYVENMQefa 204 Paramecium tetr...
EDO03707     156 Nansrghls--kveiinkSVFE---WnqIVp--------SPCFFLAMEVFDNFAHDSIRYDPVT----EEPLQGTVLisn 218 Sclerotinia scl...
Q5APE5       271 NkltsqgldsskleifnkSIFE---WkkVVd--------DPCFFIALEVFDNFSHDLIRYDNDS----GKPYEGKVVide 335 Candida albicans
Q6C0X9       274 Kasetghrs--kveiinkSIFD---WkePVn--------DPCFFVALEVFDNFAHDIVRYDNRT----LQPYQGHVLvda 336 Yarrowia lipoly...
Q7VBT2       142 F------------------KDIPicWmsMK-ELSDVP--VKGIMIAHEILDALPVDRVVSNNNK--L-FMQGVKLSTl-- 195 Prochlorococcus...
Q7V7S2       142 V------------------TSVPihWrsLN-ELAQAP--AIGVMLAHEMLDALPVERLVWRDQRl-W-RQGVC-LENv-- 195 Prochlorococcus...
5ZZW_B       219 --------------------------------hgEYY---------L---RFVqsKgPtlmttaVKHLLPEFGL------ 248 Dictyostelium d...
P36052       231 ---------------------------------qKSKs--------F---DSA--I-Dy----sCELALEQMFNdrs--- 256 Saccharomyces c...
Q4CY00       380 lstvheryyalkdpv-ilrylrylrwlqeesfhsLKVlcltggrenIdppPFT--SiEpnmndpLRVIITKLIWth---- 452 Trypanosoma cruzi
XP_001415722 271 tgelaqreap------------ladaliqrtlqaIDL-------------TADlaVdGdggaynPRGFMHSIRRalts-- 323 Ostreococcus lu...
A0BQV8       205 etisdpli----------------kevyamyqqfKQQn-----------kDQDenLeDrflfntLRKVISKYYGn----- 252 Paramecium tetr...
EDO03707     219 tgefyefytpt---------idpiasrflrvrhaATNg------------KYPhpLpQnklirsLRNSM-PFAPn----- 271 Sclerotinia scl...
Q5APE5       336 ngdffefftpelsyysnaylnlrenskysvlkqsSSVggylsa-lksfysDDVhpLlHssaklkLKNTILPYDSn----- 409 Candida albicans
Q6C0X9       337 ngdfhevytqkld------ewtklflqirtealeDYSpd---------srLGFhpLsTpwlykeARNLMWPFHSe----- 396 Yarrowia lipoly...
Q7VBT2       196 ----------------------------------NNKh-------yI---EFT--Nlpl--sdsIKNSIIDISNkidisi 227 Prochlorococcus...
Q7V7S2       196 ---------------------------------dSVAh--------L---RFT--Elfl--tdaLHSALTEARMclgiqi 227 Prochlorococcus...
5ZZW_B       249 ------DGYQVELGLAGLAISQQIANRIDKsgGAALIIDYGY--DKI------VKSSL---QAI-RDHEFV--------- 301 Dictyostelium d...
P36052       257 ---hvsPGKELYIPTKLIEILMTIKNNIPE--HRLFIVDTPQrsSPTii---sLLKSLispRPT-GSSQIVqpy----sd 323 Saccharomyces c...
Q4CY00       453 -----sPFRTLWLPTVAMLFLETCAAFFPR--HHLFLVDWSGvrQALp----gVNGPVc-qCKV----RVAkdmylrrpa 516 Trypanosoma cruzi
XP_001415722 324 --lassGDETWFVPTGSMQLMETLHAKRPN--HRFIAADFDTlpNVRie---gVNAPLv-aTQR-VGGQTDd-------h 387 Ostreococcus lu...
A0BQV8       253 -----qKSNSIFLPTGALQVLKHIKSNFQN--PSLVIADFDLlkNNFtq--esINAPIv-sKKLaKPHERLd-------y 315 Paramecium tetr...
EDO03707     272 ------LSQPEYIPTRLMQFFDILAKYFPA--HRLVTSDFHSlpDTIk----gVNAPVv-qTRY-KRRTVPv-------- 329 Sclerotinia scl...
Q5APE5       410 ------LTPGEFIPTRLLQFFQILKHRFPN--HSLISSDFNYlpKTIpg---cFNGPVv-qTVL-QNRMVDv-------- 468 Candida albicans
Q6C0X9       397 ------LSDPEFIPTRYLEFLYILKKYFPQ--ARLLSSDFTHlpETTtsrfsgYNSPVv-qTVL-DNQMVTt-------- 458 Yarrowia lipoly...
Q7VBT2       228 ppqnseEGWSTEWHSCLNNWFKETSLCLTE--GPLLIIDYALe-ANRyysksrSEGTI---ISY-SSQVSNs-------- 292 Prochlorococcus...
Q7V7S2       228 pppdaaDGWCSEWHGELKSWLSQAASALLC--GPLLVIDYALe-ARRyysamrPCGTL---MAY-RQQRASg-------- 292 Prochlorococcus...
5ZZW_B       302 D-IL---DKPGTADLSVWVDFQTIRKTVKLLknkSTAIGPV 338 Dictyostelium discoideum
P36052       324 S-IF---SDKRSGRICFMTDFLQLQNIYNGInsssssceve 360 Saccharomyces cerevisiae S288C
Q4CY00       517 DsLH---GNAGMVDICFPTDFEHLAVVYRNIc-gAHKD-IS 552 Trypanosoma cruzi
XP_001415722 388 DtYLlpeRLAGSADVFFPTCFDTLRAIDFATs-sQNTHRAN 427 Ostreococcus lucimarinus CCE9901
A0BQV8       316 EsYL---VERGVADIFFPTDFNFVQHMVKQIl-gMDSQIFK 352 Paramecium tetraurelia
EDO03707     330 StPF---VHQGYFDILFPTDFAVMDNVYRAIt-gKFTQVLS 366 Sclerotinia sclerotiorum 1980 UF-70
Q5APE5       469 StYM---VHQGYFDIMFATDFNIASEMYKQVt-sRVPRVES 505 Candida albicans
Q6C0X9       459 NtHM---VLQGYFDILFPTDFELAAQLLRHVc-gRVPEIST 495 Yarrowia lipolytica
Q7VBT2       293 N-IL---EKIGTTDITSHLCLEIIYLLA-IKn-nWNFVGER 327 Prochlorococcus marinus
Q7V7S2       293 A-LL---QDPGRWDLTAHLCLETLQLQA-EQq-gWTFLGes 327 Prochlorococcus marinus str. MIT 9313
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