5DUD,3VA7,3OPF


Conserved Protein Domain Family
CT_A_B
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pfam02626: CT_A_B (This model is not part of the current CDD release)
Carboxyltransferase domain, subdomain A and B
Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the A and B subdomains of the CT domain. This domain covers the whole length of KipA (kinase A) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.
Links
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Statistics
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PSSM-Id: 515066
Aligned: 465 rows
Threshold Bit Score: 159.904
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5DUD_A        25 GISHCGALDMPALRIANLLVGNDANAPALEI-TLGQLTVEFETDGWFALTGA----GCE-ARL-DDn---AVW-TGWRLP 93  Escherichia col...
WP_013450511  25 GVPKSGAMDDFSYELGNILVGNFQGEAVLEFtQKAGV-YEFLSDCTILLAGV----DFG-FSI-NDe---PVE-MFKTYF 93  Calditerrivibri...
P44298        25 GISHCGAMDKLALRAGNILLGNAENVPAIEV-PLGGITLQFQQDMNFCVTGA----FYE-MML-DDk---PVF-AYWRYQ 93  Haemophilus inf...
Q0P882        26 GIARSGAMDEDALRMANILLGNKQDEAGIEL-CLKGGKYEFLDENYFVLSGA----EFE-AKL-DNqkikTCK-VYQ--- 94  Campylobacter j...
WP_013490717  28 GIVTSGAMDDLSFQIGNLLLGNDRNAAGLEM-TMLGPSLHVLNDTHIVITGA----NLS-PMI-DDk---PIR-MWKTVK 96  Evansella cellu...
Q8EN14        28 GVVVSGVMDAFALQVANVLVGNERTEAGLEI-VIMGPKMKILEDIIFAIGGA----DLS-AKL-DNq---LIQ-PWKSYR 96  Oceanobacillus ...
WP_007746161  27 GFPTSGAIDQAAFCLANGLVNNPVNAAAIEF-CLLGPSLKFHCRTFIAITGA----VCP-VFI-NAq---LAE-ENQVLE 95  Oenococcus kita...
WP_014108928  24 GFAQSGALDRNSHLLANSIVKVAENNPTIEV-LLGGFKAVATQDLEIAVTGA----QSI-IKIgD-----ICQpLNKQLL 92  Glaciecola nitr...
WP_012656376  26 SL--SGPCDSLAHILGNALLGNDITKETLEM-TFTAPVIRFEERTLIALTGAefyaYTEdREI-T-----PFK-VHL--- 92  Macrococcoides ...
Q5HR17        26 GVIPSGALDELAHEIANRLVANDKNEATLEM-TQKMATIRFTEPALIALTGGnfkaETEhMKI-Y-----PNK-LYL--- 94  Staphylococcus ...

5DUD_A        94 MKAGQRLTLKRPQhGMRSYLA-VAGGIDVPPVMGSCSTDLKVGIGGLE--GRLLKDGDRLPIGKSKRDSMEAQ------- 163 Escherichia col...
WP_013450511  94 VKKGSILRDSGAItGYRSYLS-VAGGIDLPLELGSRSTFVRGRIGGIe--GRRLQKGDFLKIGKSRFRLKRPIr------ 164 Calditerrivibri...
P44298        94 VRAGQILKMARAKiGMYGYLC-VQGGFVLPQALNSCSTDLRAQIGGIE--GRCLQAGDQLQTANDHILRS---------- 160 Haemophilus inf...
Q0P882        95 ANKGDILELDLAKiGFRGYLC-VAGGFEVKSFLNSKSSDAKMGAGVFE--GRALQKDDILNTHNTFIPFNLE-------- 163 Campylobacter j...
WP_013490717  97 LHKGEKLHFGKPIeGARAYLL-VAGGIDAPIMMGSKSTYEKAKIGGIH--GGPLKEKDVLCANEVYGNIKYER------- 166 Evansella cellu...
Q8EN14        97 ASKGQILSFGQPAqGSYAYLA-IAGGIDVPSVMKSKSTFVKARLGGFH--GRFLQKGDILSSNDSYGINARPGr------ 167 Oceanobacillus ...
WP_007746161  96 IFENDVLTFGPVTrGRYGYIAfAAGGLLTVPVLDSRSTTLRAGIGGLD--RHLLQKGDQLPLNECYQMPSLQSr------ 167 Oenococcus kita...
WP_014108928  93 WKKGETLQIMEPSlGARNYIA-CRHRFKTAMFLNSCCAVMREKTGGLkldGKGLQIGDELSYENKALMTANAStsgvpdi 171 Glaciecola nitr...
WP_012656376  93 MEKGDVLKFRQPKkGTRIYMA-VAGGMHFVNNLSGNIV---------------LKAGTRIELERDYNELHKKMfdnled- 155 Macrococcoides ...
Q5HR17        95 INEGETLKFNETSrTSRVYLA-VGGGFKLEKWLHSASTDFNVEIGGFE--GRKLKKGDEIELKHHYSQRHLKLfenlsd- 170 Staphylococcus ...

5DUD_A       164 -----------------GVKQLLW-----GNRI-RALPGPEYHEFDRASQDAFWRSPWQLSSQSNRMGYRLQG-----Qi 215 Escherichia col...
WP_013450511 165 ----------------lGKTDQPDfgisrI----RVIPSPRM-----KSIENFLNVKYNVAVDIDRMGIRLknsek---- 215 Calditerrivibri...
P44298       161 --------------------EIGIapiplRDVI-RALPSSEYQAFKRKSQYYWWRNEWTLQSNSDRMGYRF-Qg---qT- 214 Haemophilus inf...
Q0P882       164 -----------------ARECENPlfkspKEPIiRVILGTNEDAFTQKGIETFLNTTYKVGLKSDRMAIYA-------Es 219 Campylobacter j...
WP_013490717 167 -----------------SISSTIIpnietNSRI-RVIPGPQDNMFTQEAIARFYSSTFKISSQSDRMGYRIEGe----A- 223 Evansella cellu...
Q8EN14       168 -----------------QLKNKDIpdydyNRPI-RVIKGPDQQLFSSTSYDSFFASTYKMSPQSDRMGYRLEGe----P- 224 Oceanobacillus ...
WP_007746161 168 -----------------QYAVDEKkvvtgI----RVVKGPQWSLFDPAAQENLVKQTFTVSTQADRMGYRLTE-----Kl 221 Oenococcus kita...
WP_014108928 172 aklahekqinqsasrsaLKEVSLPttslaKHYTvRLVLGYQHALFDHKMKARFFNQCFSVSNEASNMGIRLTGesieqV- 250 Glaciecola nitr...
WP_012656376 156 ------------qrcatWGIDAYSlarlyYSDVfHII---STAALDTLSRKQLTQDTYTVTQRFDRTGFILEGnkvklI- 219 Macrococcoides ...
Q5HR17       171 ------------krttdWGIDGYAlsfnyVSDVfHVIKNKGTEDFKKEATRRFTTAEYSVSSKTNRVGMVLDGpqikaY- 237 Staphylococcus ...

5DUD_A       216 LKRtt--dR-ELLSH-GLLP-GVVQVpHNGQPIVLMNDAQTTGGYPRIACIIEADMYHLAQIPLGQPIHFV 281 Escherichia coli K-12
WP_013450511 216 ---iysnvEyDIVSE-PVVP-GVVQInNSGEPTILMNDCQTTGGYRILGYVIDADLYKVAQLRPRDTISFE 281 Calditerrivibrio nitrore...
P44298       215 LELkq--pL-EMLSH-AIQF-GSVQVpPSGQPIILMADAQTTGGYPKIANVIDADLGALAQVRLGSTIKFE 280 Haemophilus influenzae R...
Q0P882       220 SESiehknSaDIISD-PAVF-GSIQVpKSGIPIILMAGRQSTGGYTKIATVIENDLSLLAQAKLGSSFKFQ 288 Campylobacter jejuni
WP_013490717 224 IEHks--eR-EMITD-GVTK-GSIQVpGDKNPIILMADSQTSGGYPKIASVISVDLWKVAQKLPGQTLTFQ 289 Evansella cellulosilytica
Q8EN14       225 ISHidgdsA-DIISD-AILP-GTIQIpANGQPIILLADRQTSGGYARMATVISVDLPQVIQRMSGTAFTFE 292 Oceanobacillus iheyensis
WP_007746161 222 LPaa---qV-SLLSE-GTVF-GNIQItRNGQPIVLLADRQTTGGYPVIATIIAADFSAFVQMPLGQKFAFT 286 Oenococcus kitaharae
WP_014108928 251 --------SvKLYSE-GIAN-GAVQItPTGLPIIMLAERQTIGGYPKIGSVIANDLPELGQCRPGSTIQFE 311 Glaciecola nitratireducens
WP_012656376 220 --------SnN---NvSVERcGTLQItHQHDIAISLKHIAQDDDYVQFAYIADYHLAKLSQKKPGSKLLFK 279 Macrococcoides caseolyticum
Q5HR17       238 --------YdDMPAHqSVKR-GTIQVkRDGTPIVLLNDHYTLGSYPQIGTIASYHLTKLAQKPQGSKLKFQ 299 Staphylococcus epidermid...
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