4Q84


Conserved Protein Domain Family
YcaO

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pfam02624: YcaO 
YcaO cyclodehydratase, ATP-ad Mg2+-binding
YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyzes ATP to AMP and pyrophosphate.
Statistics
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PSSM-Id: 396956
Aligned: 243 rows
Threshold Bit Score: 91.9663
Threshold Setting Gi: 270509690
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Q84_A                          59 NGKGATKKAALASALGEYFERLstnyffadfwlgetiangpfvhyPNEKW-FP-LTEnDDV---PEGLLDDRLRAFYDPe 133
WP_014690720                   224 IGRCLSFARSRRTAVLEGLERYtgf------------------hrQPTGR-AVeASL-AEL---DAQGLDPRTLGYHDDs 280 unclassified Actinoplanes...
IGS:B005_2694                  236 AGRSRSFGRSRVTAILEGLERYagf------------------hhRASSGkIR-ASL-RRL---GDLAIDPRDLGHHSKe 292 Nocardiopsis alba ATCC BAA-2165...
jgi:Caci_3696                  254 SGQANSFEDSRRLAFLEGLERYagt-----------------hrrVPGPS-VI-AAF-DDL----DDALDPRTCGEYAPe 309 Catenulispora acidiphila DSM 44928...
WP_012013656                   258 SGQSSGYDASRSLAYLEGLERYagt-----------------hrrRNVTP-VI-AAY-ADL---GPDALHPDRCGRHPDe 314 Salinispora tropica...
jgi:Caci_4207                  253 GGHRDTYRRSLRTGVLEGFERYagl-----------------rprGQEPP-LV-AAF-DDL---TVPALDPRDCGMYAPe 309 Catenulispora acidiphila DSM 44928...
jgi:Caci_3690                  277 GGHTDSYQASERVGVLEGFERFagm-----------------rprGKRTT-VF-AAL-AEL---KEPAVDPREVGLYsqe 333 Catenulispora acidiphila DSM 44928...
EST24436                       254 GGHADTFAQSVRIGVLEGLERYagm-----------------rsrAKAAG-VL-GSL-NGLraaGEHTLDPREVGLYSEe 313 Streptomyces niveus NCIMB 11891...
WP_012013663                   243 GGHADGYRSSSRIAVLEGLERaagl-----------------rprGKRTA-VT-ATL-REL---GDDALDPRECGLYtda 299 Salinispora tropica...
KoreaUniversity:VAB18032_21135 265 SGHANSYGSSETYALLEGLERYagq-----------------fprARTTT-VF-DSY-TNL---APHALDPAGLGYHPAf 321 Verrucosispora maris AB-18-032...
4Q84_A                         134 neltgsmlidlQSGNEDRGIcgLPFTRQSDNQT-VYIPMNIIGN-----------LYVSNGMSAGNTRNEARVQGLSEVF 201
WP_014690720                   281 ryae--pdfpfAPLGRHERLrwVPVTPLGGGVP-RYLPEPALSWahrpgsrrpffYDTSNGFALGQSYEEAALHGLLEIA 357 unclassified Actinoplanes...
IGS:B005_2694                  293 qydl--egfpfAPLGDEEEVdwVEVSPPGADAPcRYLPENVLYWarrgtryksffADTSNGFALGQTPEEAALHAALEVV 370 Nocardiopsis alba ATCC BAA-2165...
jgi:Caci_3696                  310 tyaa---dsmtSPFDPKRPIpwVPGYSLRTGRR-VHVPARLVYYsagvq-adnfvFECSNGCATGSVLEEAILFGLLELI 384 Catenulispora acidiphila DSM 44928...
WP_012013656                   315 vydt---dpilRRFDPQRPIpwVWGQNLHTGKP-VLVPRRLCFYsspaa-gdtfvLSSSSGCATGSCREEAALFGLLELI 389 Salinispora tropica...
jgi:Caci_4207                  310 fyeq---dpetKAFATDRKIpwVRGYSLRDDRE-ILVPLVMSYYhceph-aerfvQQCSNGCASGGSVAEAVLSGLLELI 384 Catenulispora acidiphila DSM 44928...
jgi:Caci_3690                  334 fhr---rnpliKEFRPDSPIpwVWGYSLRDKRP-VLVPEILTYYhapggaqnrfvQESSNGCASGGSLAEAAYHGLMEVV 409 Catenulispora acidiphila DSM 44928...
EST24436                       314 fhra---nprvTPFHPDRELpwVWGYSLRDHRP-VLVPEVLTYYhapgl-enrfvQESSNGCASGGCMEEAVYFGLMEVV 388 Streptomyces niveus NCIMB 11891...
WP_012013663                   300 fyq---anpylHRFDVDRPItwVWGWSLRDQRT-LLVPEILAYYhaasv-eerfvQETSNGCASGGSMVEAIYHGLMEAV 374 Salinispora tropica...
KoreaUniversity:VAB18032_21135 322 yhgh---glyyAPYSPTEPMhwVWGYSLRDRAP-RLVPEQLVYYldrrtdqrkfvQECSNGCASGSCLEEALLHGMLELV 397 Verrucosispora maris AB-18-032...
4Q84_A                         202 ERYVKNRIiAESISLPEIPadvLA--RYPAVVEAIETLEA-EgFPIFAYDGSLGGQYPVICVVLFNpaNGt--CFASFGA 276
WP_014690720                   358 ERDAFLLTwYHRLLLPELT---LGp-aDRGIRQLVDRVAVvTgFRLRLYWAAVDTGIPVVLALARRdaAAgpcTFVSAGA 433 unclassified Actinoplanes...
IGS:B005_2694                  371 ERDAFMLTwYRRLLLPEIV---LGr-qDRDLADLVDRIEVfTgFRVRLFWAAVDTGIPVVIALAARdaDSgpcRFLSAGA 446 Nocardiopsis alba ATCC BAA-2165...
jgi:Caci_3696                  385 ERDAFLLGwYGGAELTEID---PAscPSPALAAMIDRAGLr-gYDVHVFDNRIDLAIPVVTAVAVRrdGGpgtLAFAASA 460 Catenulispora acidiphila DSM 44928...
WP_012013656                   390 ERDAFLLAwYGNLTLPRID---LDtcP-PVVRALVDRAELq-gYRLYAFDNRIDLDVPVVTSLAVRhdGGpglLSFAAAA 464 Salinispora tropica...
jgi:Caci_4207                  385 ERDAFLLTwFGRQSLPELD---PRtsEHAETRHLVERLAMy-gYEARFFDTRLAFPVPVITAVAVRrtPGlgaLCFGAGA 460 Catenulispora acidiphila DSM 44928...
jgi:Caci_3690                  410 ERDAFLIAwYSRTPLPEID---PAssTVVHTRALVDRLEMy-gYQARFFDARLTFPIPVVVAAAVRrdGGtgaLCFGAGA 485 Catenulispora acidiphila DSM 44928...
EST24436                       389 ERDAFLLTwYGKAALPELD---PRtsTRAATRQMVDRLEMy-gYEARFFDTRISFPIPVITGVAVRpdGGpgrMCFGAGA 464 Streptomyces niveus NCIMB 11891...
WP_012013663                   375 ERDAFLLSwYGGRSLPEID---PAsiDRPRTRMMVDRLAMy-gYRARFFDTRMTFDIPVVTAVAVRrdGGlgtLAFGGGA 450 Salinispora tropica...
KoreaUniversity:VAB18032_21135 398 ERDAFLLAwYGSARLAEID---PAtcRDERVHFMIDRVNLl-gYDLRLFDTRADLPVPVVTAVAVKrgDGlgqLCFAAGA 473 Verrucosispora maris AB-18-032...
4Q84_A                         277 HPDFGVALERTVTELLQGRgLKdlDVF----------TPPTFddeEVAEHTNLeTHFi-dSSGLIsWdlfkqdADYpF-- 343
WP_014690720                   434 NLHPRAAAESAIFEVAAILsAV--THTfdrdrahgrrLAADFg--LVRTMADH-SLLgalPQSRP-W------FDFlTtp 501 unclassified Actinoplanes...
IGS:B005_2694                  447 SLFPAAAAESALVELAGLVaAM--CVDfedrterahaMSLDFd--QVRGLDDH-SLVaalPSSRG-W------FDFlTra 514 Nocardiopsis alba ATCC BAA-2165...
jgi:Caci_3696                  461 GFDPRTAVEGAVSEILTYIpHL--PRQvaerpqelaaMAGDFd--LVRRLPDH-AALyglPEMAR-H------ARRyLgr 528 Catenulispora acidiphila DSM 44928...
WP_012013656                   465 HVDPQQAVTGALAEALTYIpHQ--PATvrrrraelerMADDYt--LVRRLPDH-SALfglPRMAV-H------AGSyLnd 532 Salinispora tropica...
jgi:Caci_4207                  461 ALDPEEALAAGLAEIATDAlHA--RRRaerdeaelraMAADFt--QVIGLHDH-SRLyglPEMAQ-Y------ASFlLda 528 Catenulispora acidiphila DSM 44928...
jgi:Caci_3690                  486 SLDPQAALAGGLCEIATDAvNL--PWRtelgrerlsaMARDFd--RVEVLHDH-PLVyglPEMTR-H------AAFlLdg 553 Catenulispora acidiphila DSM 44928...
EST24436                       465 GLDPESALSGALCEIATDAvNL--QGRtardearlraMATDYd--KVAALHDH-PLAygiPEMGN-N------AHFlIge 532 Streptomyces niveus NCIMB 11891...
WP_012013663                   451 SLDPQVAITAALCEIATDSvMV--RVRaradeprlrrMTTDFs--RVQGLHDH-PLLyglPEMAR-H------AAFlLdh 518 Salinispora tropica...
KoreaUniversity:VAB18032_21135 474 SLDPDDAVRAAVCETASYVpGF--DERvaaseaelreMTRDYt--KVTELSHH-ALLyglPEMTD-H------ARFlFdn 541 Verrucosispora maris AB-18-032...
4Q84_A                         344 --------------------VDWNFSGTTEEEFATLMAIFNKEDKEVYIADYe-----HLGVYACRIIVPGMS 391
WP_014690720                   502 erpel---------aladavAAHPVAARLDADLDHVRARLQAAGLSAYAADMttpelrWRGLVCTRVFVPGCL 565 uncl...
IGS:B005_2694                  515 drpiv---------rmaellKENPGHATVRADLDYVAERIGGAGASVYFADVttrelrWRDLVCVRAITPGLL 578 Noca...
jgi:Caci_3696                  529 sdrggtgir-sydevyaqwsRRRPDTGDLLDDVLLCRDEIAAAGHDVIVVDQttpeqrRLGLRTVCTLAPGLL 600 Cate...
WP_012013656                   533 rgalpi--------eqvfagyRTPGTPDLRDDLRRVLDLLSARGLEAIMVDQttpeqeAIGLRSVCTVVPGLL 597 Sali...
jgi:Caci_4207                  529 praall-------plkqafgEAPPRTGDLREDLAACVGHVTAAGFDTIVVDQtapeqrRLGLSTVGVIVPGLV 594 Cate...
jgi:Caci_3690                  554 apaaaaprslaevraevaaaGLAP-SADLREDLERCVAAVAAAGFDVIVVDQtvpeqrDLGAVTVSVLVPGLV 625 Cate...
EST24436                       533 pgaprprk--rplaeaygdgSLPPVSDDLRDDLTRCVSAVTDKGFDVVVVDQtmpeqrDLGLTTVSVIVPGLL 603 Stre...
WP_012013663                   519 gtalapm-----ahlyerdrPAPPVSTDLRDDLERCLKQVTAQGFDVIAVDQttpeqrDLGLTTVSVVVPGLL 586 Sali...
KoreaUniversity:VAB18032_21135 542 pplrsm------tdlygdwlATRPTHDDLWADTEYLGGLIAGLGGDVVAVDQtcpeqeIAGVHTVAVVAPALV 608 Verr...
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