2AJ7


Conserved Protein Domain Family
FliW
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pfam02623: FliW (This model is not part of the current CDD release)
FliW protein
The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterised as being a flagellar assembly factor. Experimental characterisation was also carried out in Treponema pallidum (TP0658). In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis. The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin. FliW proteins are involved in flagellar assembly. FliW is part of a three-part feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC translation; hence FliW is required for FliC (flagellin) production.
Links
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Statistics
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PSSM-Id: 515063
Aligned: 204 rows
Threshold Bit Score: 59.8085
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AJ7_A        33 AFDQGIPAFEDEKEFVLlpfAAg-TPYYTLQSTKTV--DLA-FIIVNPFSFFPEYRVKLPEATIAQLNITne-nD-VAIF 106 Halalkalibacter...
Q0P9H9         4 AVKCPILGFEETKNMEF---STidEVFVRLKSLDGK--DFS-FVLINPYLIRPDYEFDIPTYYQELLSLTpe-sN-MKIF 75  Campylobacter j...
Q7MR59         4 ELKSPLLGFEEIKEFDL---VEvdEMFAKIKAINNP--SIE-ITLANPYALRE-YSFDIPAYIQALLDINaq-sK-VRVF 74  Wolinella succi...
WP_006017197   4 ELKAPILGFERILEVEL---THidDLFSRITSLDG---SIS-MILANPYKLRD-YHFSIPKYIELLLELDyd-sQ-VEVF 73  Helicobacter bi...
O25769         4 FLKAPILGFEHINEVRL---EKidSLFSRLISQTNSpmALD-MVLVNPYCLRE-YSFVIPKYIELLLELDsh-sK-VEVY 76  Helicobacter py...
WP_013022550   4 iLKSPILGFEHITEIEL---EKidSLFAKISNQKE---QFE-IFLANPHALCE-YSFEIPKYVELLLDLEkd-sR-LEVY 73  Helicobacter mu...
Q7VHN3         4 ELKMPILGF-DATKIEL---EKidETFSKIRGLDGK--QPFeITLINPFSLCD-YAFTIPTADERLLDLDesrgDkVEVY 76  Helicobacter he...
WP_013327954   4 EVKGEILGFVNTKQVDI---NGidELFSTMIDSHNE--GIS-FTLVNPYILRE-YSFDIPMETKNLLNINsn-sK-ISVY 74  Sulfurimonas au...
WP_012856653   4 SVKAPIPGFETIKEVEL---EKidEFFIKFISKSD---TTT-FTLINPFMLRP-YEFEIPEYFRNLLGIEen-sN-VLIL 73  Sulfurospirillu...
Q30TI8         4 dVCVPILGFENVKEVTL---EKidDAFMRMESSNDE--HIS-FTLINPFALRE-YDFEIPDATQKLLEIDek-sN-ILIL 74  Sulfurimonas de...

2AJ7_A       107 SLLTVKEPFSETTVNLQAPIVINANKQXGKQLVL-GDT 143 Halalkalibacterium halodurans
Q0P9H9        76 NIVAIAKSIEESTVNFLAPVVINLDNNTMVQVIL-DTV 112 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Q7MR59        75 CTVVIQNPIDESRVNFLAPLIFNDDNQTAAQIAL-SIK 111 Wolinella succinogenes DSM 1740
WP_006017197  74 CVVVIQKKLEESMVNFLAPLIFNPKNGYAAQVAL-SIM 110 Helicobacter bizzozeronii
O25769        77 CVVVLQKNLEDSMVNFLAPLVFNSKNGFGAQVAL-SMM 113 Helicobacter pylori 26695
WP_013022550  74 CVMILQKDLENSLVNFLAPIVFNTENKKAAQIAL-SML 110 Helicobacter mustelae
Q7VHN3        77 CVVVLQKPIENSVVNLMAPFVFNPANACALQVTTlPVA 114 Helicobacter hepaticus ATCC 51449
WP_013327954  75 NILLIQKPLEKSTINFLAPIIINHDNNTLAQIVL-EPK 111 Sulfurimonas autotrophica
WP_012856653  74 NIMIIATPIETSTINFIAPLVFNVDTHSVAQVIL-DAN 110 Sulfurospirillum deleyianum
Q30TI8        75 NIAIIQTPVEDTVVNFIGPMIFNTDNNKAAQLVLsEST 112 Sulfurimonas denitrificans DSM 1251
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