2AJ7


Conserved Protein Domain Family
FliW

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pfam02623: FliW 
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FliW protein
The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterized as being a flagellar assembly factor. Experimental characterization was also carried out in Treponema pallidum (TP0658). In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis. The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin. FliW proteins are involved in flagellar assembly. FliW is part of a three-part feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC translation; hence FliW is required for FliC (flagellin) production.
Statistics
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PSSM-Id: 396955
Aligned: 238 rows
Threshold Bit Score: 75.6015
Threshold Setting Gi: 504557502
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AJ7_A        32 IAFDQGIPAFEDEKEFVLlpfAAgTPYYTLQSTKTV--DLAFIIVNPFSFFPeYRVKLPEATIAQLNITNENDVAIFSLL 109 Bacillus halodu...
WP_006655814   6 fiVKSHILGFEDVSEVELa--EIdDGALAFLSMVGR--DAELLLINPYKVRE-YSFEVPAGIQALLDMKADSKVKVFCVF 80  Helicobacter ca...
Q7MR59         3 YELKSPLLGFEEIKEFDLv--EVdEMFAKIKAINNP--SIEITLANPYALRE-YSFDIPAYIQALLDINAQSKVRVFCTV 77  Wolinella succi...
CBY82738       3 yQLKAPILGFENMMEVELt--KIdELFSKVSSLDG---AISLVLANPYKLRE-YSFSIPKYIELLLELDGSSEVEVYCVV 76  Helicobacter fe...
CCB79097       3 YELKAPILGFERILEVELt--HIdDLFSRITSLDG---SISMILANPYKLRD-YHFSIPKYIELLLELDYDSQVEVFCVV 76  Helicobacter bi...
O25769         3 yFLKAPILGFEHINEVRLe--KIdSLFSRLISQTNSpmALDMVLVNPYCLRE-YSFVIPKYIELLLELDSHSKVEVYCVV 79  Helicobacter py...
CBG39455       3 yiLKSPILGFEHITEIELe--KIdSLFAKISNQKE---QFEIFLANPHALCE-YSFEIPKYVELLLDLEKDSRLEVYCVM 76  Helicobacter mu...
WP_015902113   3 FTVKKPIPGFENVNEVELs--KVdESIAVLKDNEGR--AL-FSLINPFVLRE-YSFDVPADVKALLDINENSNIEVYNNI 76  Nautilia profun...
WP_013327954   3 yEVKGEILGFVNTKQVDIn--GIdELFSTMIDSHNE--GISFTLVNPYILRE-YSFDIPMETKNLLNINSNSKISVYNIL 77  Sulfurimonas au...
WP_012856653   3 FSVKAPIPGFETIKEVELe--KIdEFFIKFISKSD---TTTFTLINPFMLRP-YEFEIPEYFRNLLGIEENSNVLILNIM 76  Sulfurospirillu...
2AJ7_A       110 TV-KEPfSETTVNLQAPIVINANKQXGKQLVLGDTAYNRK 148 Bacillus halodurans
WP_006655814  81 VReKQT-E-IRINFLAPIILNYDNHTLAQVILTAKDYPNf 118 Helicobacter canadensis
Q7MR59        78 VIqNPI-DESRVNFLAPLIFNDDNQTAAQIALSIKDYPDf 116 Wolinella succinogenes DSM 1740
CBY82738      77 VVqKNL-EDSMVNFLAPLIFNPNNGYAAQIPLSIMDYPdf 115 Helicobacter felis ATCC 49179
CCB79097      77 VIqKKL-EESMVNFLAPLIFNPKNGYAAQVALSIMDYPdf 115 Helicobacter bizzozeronii CIII-1
O25769        80 VLqKNL-EDSMVNFLAPLVFNSKNGFGAQVALSMMDYPdf 118 Helicobacter pylori 26695
CBG39455      77 ILqKDL-ENSLVNFLAPIVFNTENKKAAQIALSMLDYPHF 115 Helicobacter mustelae 12198
WP_015902113  77 VMkDPV-TESVVNFKAPFLFNLDNNTCAQVVLGEEKFakl 115 Nautilia profundicola
WP_013327954  78 LIqKPL-EKSTINFLAPIIINHDNNTLAQIVLEPKQNPdy 116 Sulfurimonas autotrophica
WP_012856653  77 IIaTPI-ETSTINFIAPLVFNVDTHSVAQVILDANQYPKf 115 Sulfurospirillum deleyianum
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