2X06,1X0A,4FJU,2G8Y,1WTJ,1S20,3UOE


Conserved Protein Domain Family
Ldh_2

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pfam02615: Ldh_2 (This model is not part of the current CDD release)
Malate/L-lactate dehydrogenase
This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.
Statistics
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PSSM-Id: 515058
Aligned: 277 rows
Threshold Bit Score: 246.602
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2X06_A          6 ENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVKESPATAVIDGDLGL 85  Methanocaldoco...
WP_014021380   10 EILKTTFANILIQRGFEAKKAKICAELFSMASLDGVASHGLNRFPAFLEQVEGGRVIPEAEPVLEFSLPIMERWDGQLGA 89  Cyclobacterium...
WP_015266881    8 SEIQATLKQVLLHHQFTDEKAALSAYLFAKASLDGVPSHGLNRFLDYLRYVDLGWIIPTADPEVVAKFGSFERWNGHSGP 87  Echinicola vie...
WP_013768801   13 TEMHAHFAKILLQYGMPHDRAHTCAEIFTQNSIDGVYTHGVNRFPRFVQYLRDGYIQAEASPTLTHKFGGIEQWNGNLAP 92  Haliscomenobac...
WP_015614859    6 EEMKSEFKRILIKKGFSEERAEVSAQLFTETSCDGVYSHGYVRFPRVIEYIDKGLIDVEAVPSKVEGIGAFEKWDGNIGM 85  Clostridium pa...
WP_022068349    6 EDMKREFERVLLKKGFSQERAETSAKMFADTSLDGVYSHGYQRFPRVIEYIDKGYIHVNAIPEKLAGVGAAERWDGHLGM 85  Blautia
WP_012199625    6 DDMVKEFTRVLIKYGFSEEKAKLSAKLFADNSLDGVYSHGVNRFPRVISYIEKGYIKPEQTAAKTEAFGCVERWDGNLGM 85  Lachnoclostrid...
CDE26427        6 EDLLNKFERILLQRGLSKENAHLAAEVFAKNSLDGIYSHGVNRFPRVVSYLDKKEIDPSATPTKELSFGAMERWNGHRGF 85 
WP_022278842    6 DVMVQEFARVLEKKGFTHEDAENAAIIFAQNSLAGVYSHGLNRFPRVVSYLEKGEIDPNARATCEMKMGAIERWDGHRGF 85  Dorea formicig...
17_pfamImport   4 EVMVNEFERVLTKYGFEPKDAKASAELFAQNSMAGVYSHGLNRFPRVVEYLKKGEIDPKVKAEKIMGFGAFERWDGHRGF 83 
2X06_A         86 GQVVGKKAXELAIKKAKNVGVGVVATRNANHFGIAGYYSELAXNQDXIGITITNTEPAXAPFGGKEKILGTNPIAIAFKg 165 Methanocaldoco...
WP_014021380   90 GMYNASFAMKRAAAMAIKNGMGCVALNNTNHWMRAGNYGWQAAEAGCISICFTNTIPNMPAWGGKEPKLGNNPLVIGLPy 169 Cyclobacterium...
WP_015266881   88 GNLNAHAAMDAAISMAKSTGFGVVALQHTNHWMRAGNYGWQAVEAGCIGICFTNTKPNMPGWGGSEPKLGNNPLVVAIPr 167 Echinicola vie...
WP_013768801   93 GPINALHATERAMALAQDHGIACVGLANTNHWMRGGTYGWKAAKAGYIFLGWTNTIANMPAWGAQDAKLGNNPFVIAIPy 172 Haliscomenobac...
WP_015614859   86 GNLNAKFCMERAIELAKTNVIGCVALKNTNHWMRGGSYGWQAADAGCIGICWTNTFTNMPAWGAKDSRIGNNPLILSVPr 165 Clostridium pa...
WP_022068349   86 GNLNAASAMKRAMELAGEFGIGLVAMCNTNHWMRGGTYGWQAAESGYIGICWTNTMPNMPAWGAVDSKIGNNPFVMAVPg 165 Blautia
WP_012199625   86 GNLNAQICMDRAIELSRTHGIGCIAIKNTNHWMRGGAYGWQAANAGCIGICWTNTMPNMPAWGAKDRRIGNNPFIVAIPr 165 Lachnoclostrid...
CDE26427       86 GPLNATLAMKRACELSEQYGIGIVALGNNNHWMRGGTYGWQAANNGKIGICWSNTTVNMPAWGGKNPKIGNNPFIMAVPq 165
WP_022278842   86 GPLNAKRAMDRACELAKENGIGCVALGNNNHWMRGGTYGWLAADHGCIGICWSNTMPNMPAWGGLNRKIGNNPLIMAVPr 165 Dorea formicig...
17_pfamImport  84 GPLNAKLAMDRAVELAKEFGMGIVALGNNNHWMRGGSYGWQAADQGCIGICWSNTCPNMPAWGGMDRKIGNNPLIFAVPr 163
2X06_A        166 --NkYKFSLDXATASIARGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALE-GCILPFGGPKGYGLALAIEXLSAI--G 240 Methanocaldoco...
WP_014021380  170 knK--AVILDTAMTQYSYGKMAIYKRSGKQLPYAAGFDAEGQLSKNPIEVIAeKLPLPIGLWKGAGLSLMLDLLASGlsD 247 Cyclobacterium...
WP_015266881  168 qnG--PIVLDMAMSQFAYGKMAIHAKAGKEMPYDAGFDEAGNLSRSPSAIIEkEMALPIGLWKGAGLSLVLDMLAMVlsG 245 Echinicola vie...
WP_013768801  173 gdE--AIVLDMAMSQFSFGAMEQSAMKGEMLNVPGGYDKTGQMSHDPQAILEtGRSIPIGFWKGAGFSLLLDILASLltG 250 Haliscomenobac...
WP_015614859  166 egG-NHVVVDLAMAQFSYGKIEVTKLNKEQLPIPGGYDSKGNITTDPEEIEKtGRVLPIGYWKGSGLSILLDLIATVlsG 244 Clostridium pa...
WP_022068349  166 pqG-KPVVVDMAMAQYSYGKLAVCRQAQTDLPYPGGYDEAGVLTCDPAAIEKtRRVLPIGYWKGSGMSILLDLAGAAltL 244 Blautia
WP_012199625  166 ssG-AHVVADCAMSQFSYGKVEEYRLNGKKLPIPGGYDENDEITNDPAAIEKtSRILPMGYWKGSGLSIAFDLIATVlsG 244 Lachnoclostrid...
CDE26427      166 snG-EHVVIDCAVSQYSYGKVEETRLKGLQLPFPGGYDSNGNLTTDPAEIERtGRFLPMGYWKGSGFSIALDLIATVltN 244
WP_022278842  166 snG-EHAMIDCAVSQFSYGKIEDCRLKGQKLPVPGGYDTKGELTTDPSEIEKtWRVLPMGYWKGSGLSIVLDLIATVltD 244 Dorea formicig...
17_pfamImport 164 snG-EHVVIDCAVSQFSYGKLEDCRLKGQQLPVPGGYDTNGNLTTDPGEIEKtWRVLPMGYWKGSGISIALDLIATVlsN 242
2X06_A        241 GAEVG---TKVKGTanpeerctkGDLFIAINPEFF-XGKEEFKRKVDELLDEIKNSEPAEGF-EILIPGEIEERNKXKR- 314 Methanocaldoco...
WP_014021380  248 GQSSQeigR--QQEey-----gvSQFFLCIHPEVMgISKTNLDGKIEHTIADLKQSKVFD-GmDIHFPGEQSFIRREENl 319 Cyclobacterium...
WP_015266881  246 GDATHevgT--HEGer-----glSQVFLALDPKGFg-LEEWMEERLDKVIQDLKKSGVFQEGdSLRYPGEQTLNTRDYNt 317 Echinicola vie...
WP_013768801  251 GAATHevsK--TSVey-----gvSQVFIAIDPQKLg-NHVAIASMLEEIIQDYHASIPMDEGkKISFPGERVLATRTANv 322 Haliscomenobac...
WP_015614859  245 GNSVFkigKIDGSSey-----qlSQIFIAIDAERVa-GNEFLKSAVNEVLNDIKSSERVDENkEIFYPGERTLNTRERNl 318 Clostridium pa...
WP_022068349  245 GRTVSkigKE-CKEey-----glTQVFIAVKPELLsGDAEAAKALAEETLKDIQNSVPEHANkKIRYPGEGTLIRRKENt 318 Blautia
WP_012199625  245 GNSVTeigKL-GEDef-----aiSQVMIAIDPSHFn-DVALTDELINNVLDDIKASVPVKENgSIYYPGESSLNTRIENt 317 Lachnoclostrid...
CDE26427      245 GNSVSkiaS--FGDei-----glTQIMIAIDPSKFn-SSELTDSIVSNILKDIKSSEPVVPGgEVYYPGELELKTRHDNs 316
WP_022278842  245 GNSVSkigT--FGDei-----glTQIMIAVDPTKFn-TVEQTDAIVDEILADVKSSEPIKEDgEVLYPGELELKNIKENk 316 Dorea formicig...
17_pfamImport 243 GNSVQkigT--FGDev-----glTQIMIAIDPTKGn-SVELTDEIVNNIVADVKSSIPVKEGgEVYYPGELELLNIKQNk 314
2X06_A        315 KDGFEIDKNLYNQL 328 Methanocaldococcus jannaschii
WP_014021380  320 RLGVPVDADIWGKV 333 Cyclobacterium marinum
WP_015266881  318 RNGVPVDEDIWRDI 331 Echinicola vietnamensis
WP_013768801  323 QNGIPVLRKVWKEV 336 Haliscomenobacter hydrossis
WP_015614859  319 EQGIPVDEDVWKKI 332 Clostridium pasteurianum
WP_022068349  319 ELGIPVDPEIWKKI 332 Blautia
WP_012199625  318 EHGIPVQEEIWEKI 331 Lachnoclostridium phytofermentans
CDE26427      317 ITGIPVIDSVWETI 330
WP_022278842  317 EQGIPVVEEVWESV 330 Dorea formicigenerans
17_pfamImport 315 EEGIPVIEEKWEEV 328
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