Conserved Protein Domain Family
Nitrate_red_del

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pfam02613: Nitrate_red_del 
Nitrate reductase delta subunit
This family is the delta subunit of the nitrate reductase enzyme, The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex. In the absence of the delta subunit the core alpha beta enzyme complex is unstable. The delta subunit is essential for enzyme activity in vivo and in vitro. The nitrate reductase enzyme, EC:1.7.99.4 catalyze the conversion of nitrite to nitrate via the reduction of an acceptor. The nitrate reductase enzyme is composed of three subunits. Nitrate is the most widely used alternative electron acceptor after oxygen. This family also now contains the family TorD, a family of cytoplasmic chaperone proteins; like many prokaryotic molybdoenzymes, the TMAO reductase (TorA) of Escherichia coli requires the insertion of a bis(molybdopterin guanine dinucleotide) molybdenum (bis(MGD)Mo) cofactor in its catalytic site to be active and translocated to the periplasm. The TorD chaperone increases apoTorA activation up to four-fold, allowing maturation of most of the apoprotein. Therefore TorD is involved in the first step of TorA maturation to make it competent to receive the cofactor.
Statistics
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PSSM-Id: 396947
Aligned: 108 rows
Threshold Bit Score: 36.9732
Threshold Setting Gi: 152030010
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Elen_2380         35 AAAGGEWDEAAGEILAALglpaevpaaagdpagppaaraagaeaaagADALLRALRPEATRLFVGaPEPACSPYEGVWAA 114 Eggerth...
Q8FQ41                72 DQLPLPVATQVVEFVDHA-----------------------------RVRGLRWLQEHYVETFD--QRRRCSLFLTYYAV 120 Coryneb...
Q8NR70                69 DVLPLPVAAHVVEFLDAA-----------------------------RVAGLRAMQEAYVETFD--QRRRCSLFLTYYAV 117 Coryneb...
Q6NJB1                36 DDLPKNTRQQFVQFLTAV-----------------------------RVMGRRGMEQHYVECFD--QRRRCSLFLSYYAV 84  Coryneb...
CeBiTec:B843_02320    52 GSLPVGVDKLLASYLDTA-----------------------------REWGRREMEQHYVDIFD--QRRRCSLFLSYYAV 100 Coryneb...
EHR50845              52 RALPDALGEPLAGFLDHV-----------------------------DATPLTELAADYVATFD--HKKRFSPYLTYFAY 100 Sacchar...
goetting:NONO_c40120  37 HALPLALGAPVRPLLSHL-----------------------------SGSPPVRLASEYVDTFD--HRKRFSPYLTYFTD 85  Nocardi...
RUNMC:MCR_0748        41 RLISPEVRQDIATLIDQM-----------------------------AALGELEAQAKYDSLFE--RGRSLSLWLFEHVH 89  Moraxel...
Q0VS56                45 PRLCAKRKQALNAWCEQI-----------------------------QHNELLDQQAEYVALFD--KGRSTSLLLFEHVH 93  Alcaniv...
AGA32800             315 YPDSGGYEALCRSLESLGragrgvrgaae-------rdaidavatawRQADAALLQAEYGRLFLG--RTPCSLHSAAYSG 385 Thioalk...
jgi:Elen_2380        115 eadgvqpLLFVNPRS--MEVERFMRSCGLG-RPEGTNEPLDHVATECELLERLALRAAGAPASegapdgagLPGGSPAAA 191 Eggerth...
Q8FQ41               121 -------GDTRQRGTaiLAFRDTLRALGFDiERDEL---PDHLCVVLEAAA--LAEPELFDDAte----vlAAHRDGIEV 184 Coryneb...
Q8NR70               118 -------GDTRQRGTaiLTFRQTLQQLGFEsERDEL---PDHLCVVLEAAA--LADSSLFDAAtq----vlSAHRDGIEV 181 Coryneb...
Q6NJB1                85 -------GDTRQRGAaiLAFQESLETLGFFlEREEL---PDHLCVVLEVAA--KAEGLAHHVAtd----mlAAHRDGIEV 148 Coryneb...
CeBiTec:B843_02320   101 -------GDTRQRGAaiLAFKESLETLGFFlDREEL---PDHLCVVLEAAA--KADGEAHAVAtd----mlAAHRDGIEV 164 Coryneb...
EHR50845             101 -------GDTRKRGMalLRFTHAYRAAGQRlDDGEL---PDHLAVVLEFAA-----TVDARIGqr----llTEHRAGLEL 161 Sacchar...
goetting:NONO_c40120  86 -------GDTRKRGMalLRLKQLYRGAGWQlDDGEL---PDHLAVVLEFAA------TEPESGlr----vlTDYRAGVEV 145 Nocardi...
RUNMC:MCR_0748        90 -------GESRDRGQamVDLMAQYDMAGFEiNAKEL---PDYLPMYLEFLSHQATINHDEMQIre----eiANISHIVTL 155 Moraxel...
Q0VS56                94 -------GESRDRGQamVDLINEYAQAGLIlDSREL---PDYLPLFLEYLSTRDETTIgq---------wlGDIRHILAL 154 Alcaniv...
AGA32800             386 a------GSLAGPAAeiADISGFYQAFGVD-IRDDQPERPDHLAAELEFYGTLLIKLAYAQLSdw-----vEASDVTAAA 453 Thioalk...
jgi:Elen_2380        192 YETFLSGHAQAWMPAFAE 209 Eggerthella lenta DSM 2243
Q8FQ41               185 LRSALDNLDSPYRHLVIA 202 Corynebacterium efficiens
Q8NR70               182 LRAALDNLDSPYRYLIMs 199 Corynebacterium glutamicum
Q6NJB1               149 LRVALEHSDSPYSRLVAa 166 Corynebacterium diphtheriae
CeBiTec:B843_02320   165 LRLALEQAGSPYAPVVTA 182 Corynebacterium vitaeruminis DSM 20294
EHR50845             162 IRLGLHEAGSPWAGVLds 179 Saccharomonospora marina XMU15
goetting:NONO_c40120 146 MRAALRESRSLWAGVLds 163 Nocardia nova SH22a
RUNMC:MCR_0748       156 LAARLMDKNSHYVGLFKA 173 Moraxella catarrhalis BBH18
Q0VS56               155 LTARLEERDAPHAlvtrt 172 Alcanivorax borkumensis SK2
AGA32800             454 ARSFLSDHLGRWSGVLSE 471 Thioalkalivibrio nitratireducens DSM 14787
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