4IIL,2FQW


Conserved Protein Domain Family
Bmp

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pfam02608: Bmp 
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ABC transporter substrate-binding protein PnrA-like
Proteins containing this domain were originally annotated as basic membrane lipoproteins. However, several proteins containing this domain were later predicted as ABC transporter substrate-binding proteins, such as PnrA (also known as TmpC or TP0319) and RfuA (also known as Tpn38 or TP0298) from Treponema pallidum. RfuA transports purine nucleosides, while RfuA transports riboflavin. Proteins containing this domain also include Med from Bacillus subtilis. Med was annotated as a transcriptional activator protein that regulates comK. This domain can also found at the N-terminus of glutamate receptor-like proteins from Dictyostelium (slime mold).
Statistics
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PSSM-Id: 396943
Aligned: 11 rows
Threshold Bit Score: 247.263
Threshold Setting Gi: 2496276
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4IIL_A  32 AVRIAVFVPGFRHDSPVYAMLCDGVERAVTQEraTGRSIGLDIIEAgp---------nQALWREKLAHLAAEQRYRLIVS 102 Treponema pallidum su...
O51298  38 KTNIALFIPGVISGSPSYKEMYDSLFEFKKNHe-NLEIKVLEAGFN------------QSEWIEMLEKLLTSKKYDFLIT 104 Lyme disease spirochete
P75062  37 IQLLVSNDEATLADKSFSEMSYEGIRRYFRSQk-HIELPSPNSSLLqdgnglwkrpgrTLSDRIATFKNIKNDGSDVIVA 115 Mycoplasma pneumoniae...
O29372  62 KLSAAFVYVSPIGDAGWTYSHDLGRQYIERVY--GVKTAYAENVAE-------------GGDDERVIREFAEQGYDVIFT 126 Archaeoglobus fulgidus
O32436  27 IEKVGMLFPDTINDLVWGTKGYKGLLNIQSKY--NVDVYYKEGVK-------------TEEDIINAIEDFHKRGVNLLYG 91  Bacillus subtilis sub...
P0CL65  29 KVVVGVLAHGSFYDKGYNQSVHDGVVKLRDNF--GIKLITKSLRPYpiegk---rlltVDEAMTEDAYEVQKNPLNLFWL 103 Borreliella burgdorfe...
P0CL55  27 AKTVSLIVDGAFDDKGFNESSSKAIRKLKADL--NINIIEKASTG---------------NSYLGDIANLEDGNSNLIWG 89  Borreliella burgdorfe...
Q45010  28 IPKVSLIIDGTFDDKSFNESALNGVKKVKEEF--KIELVLKESSS---------------NSYLSDLEGLKDAGSDLIWL 90  Borreliella burgdorfe...
Q45011  27 KIKISMLVDGVLDDKSFNSSANEALLRLKKDFpeNIEEVFSCAISG------------VYSSYVSDLDNLKRNGSDLIWL 94  Borreliella burgdorfe...
O05252  39 FSVAMVTDVGGVDDKSFNQSAWEGIQAFGKEN--GLKKGKNGYDYLqs---------kSDADYTTNLNKLARENFDLIYG 107 Bacillus subtilis sub...
2FQW_A   5 FVVGMVTDSGDIDDKSFNQQVWEGISRFAQEN--NAKCKYVTAST--------------DAEYVPSLSAFADENMGLVVA 68  Treponema pallidum
4IIL_A 103 SNPALPHVLEPILRQF----------PLQRFLVLDAYAPQEH--------------SLITFRYNQWEQAYLAGHLSALVS 158 Treponema pallidum su...
O51298 105 TNNAMQDIVDSVSSNY----------PYTKFLIFDSLVKNTNk-------------QVYSVSYNVAEEAYILGYYVGLFL 161 Lyme disease spirochete
P75062 116 TGFNQQEALQAISSDDrryladkndlAKVGFIFVDGQIEKEYnvinktpqfrstplNISSVAFRSDDGSFLTGVATAVYL 195 Mycoplasma pneumoniae...
O29372 127 TSFGFMDATITVAKDF----------PNTIFMHCSGYKTAK---------------NVGTYFGRMYQARYLSGLVAGAMT 181 Archaeoglobus fulgidus
O32436  92 HGSEYAEVFNLVGEDY----------PDMEFVISNAKAKAD---------------NVTSVHFSGEAMGFFGGMTAAHMS 146 Bacillus subtilis sub...
P0CL65 104 IGYRFSDLSVKLSYER----------PDIYYGIIDAFDYGDIqv----------pkNSLAIKFRNEEAAFLAGYIAAKMS 163 Borreliella burgdorfe...
P0CL55  90 IGFRLSDILFQRASEN----------VSVNYAIIEGVYDEIqi-----------pkNLLNISFRSEEVAFLAGYFASKAS 148 Borreliella burgdorfe...
Q45010  91 IGYRFSDVAKVAALQN----------PDMKYAIIDPIYSNDpi-----------paNLVGMTFRAQEGAFLTGYIAAKLS 149 Borreliella burgdorfe...
Q45011  95 VGYMLTDASLLVSSEN----------PKISYGIIDPIYGDDVqi----------peNLIAVVFRVEQGAFLAGYIAAKKS 154 Borreliella burgdorfe...
O05252 108 VGYLMEDSISEIADQR----------KNTNFAIIDAVVDKD---------------NVASITFKEQEGSFLVGVAAALSS 162 Bacillus subtilis sub...
2FQW_A  69 CGSFLVEAVIETSARF----------PKQKFLVIDAVVQDRd--------------NVVSAVFGQNEGSFLVGVAAALKA 124 Treponema pallidum
4IIL_A 159 ASAMRFANAdkki----------gliaGQSYPVMTQTIIPaFLAGARAVDPAFEVDVRVVGNWYDAAKSADLARILFH-E 227 Treponema pallidum su...
O51298 162 KEFIKSGFGnaa------------liaGQNYPVMNDYIYRyFKKGILDTGMRSEVYYRVLGNWHDSNLAKLLSDSLIKdS 229 Lyme disease spirochete
P75062 196 NLNQDYFLKkngatnnssqdltvsgfvGVPIPSTLSFLNG-FRLGIAYFNEVIYTHLSDAETTSDNKSNSSSASNSVL-V 273 Mycoplasma pneumoniae...
O29372 182 KTNKIGYVA------------------AVPIPEVIRGINA-FALGVKKVNPDAKIYVVWTGTWYDPAKEKEAALSLID-E 241 Archaeoglobus fulgidus
O32436 147 KTNQVGVIA---------------------SFTWQPEVDG-FIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKN-E 203 Bacillus subtilis sub...
P0CL65 164 RKEKIGFLT------------------GPMSEHVKDFKFG-FKAGIFYANPKLRLVSKKAPSLFDKEKGKAMALFMYKeD 224 Borreliella burgdorfe...
P0CL55 149 KTGKIGFVG------------------GVRGKVLESFMYG-YEAGAKYANSNIKVVSQYVGTFGDFGLGRSTASNMYR-D 208 Borreliella burgdorfe...
Q45010 150 KTGKIGFLG------------------GIEGEIVDAFRYG-YEAGAKYANKDIKISTQYIGSFADLEAGRSVATRMYS-D 209 Borreliella burgdorfe...
Q45011 155 FSGKIGFIG------------------GMKGNIVDAFRYG-YESGAKYANKDIEIISEYSNSFSDVDIGRTIASKMYS-K 214 Borreliella burgdorfe...
O05252 163 KSGKIGFVG------------------GMESELIKKFEVG-FRAGVQAVNPKAVVEVKYAGGFDKADVGKATAESMYK-S 222 Bacillus subtilis sub...
2FQW_A 125 KEAGKSAVGfi---------------vGMELGMMPLFEAG-FEAGVKAVDPDIQVVVEVANTFSDPQKGQALAAKLYD-S 187 Treponema pallidum
4IIL_A 228 GVDVMMP--ICGGANQGVLAAARELGFY-------VSWFDDNG-----YARAPGYVVGSSVMEQERLAYEQTLRCIRGE- 292 Treponema pallidum su...
O51298 230 GALVILP--IVGPAVEGVLSSVRENNIS-------AVLFDSED-----YLDNKENIIGSGITNQKYYVSHILDKALKSE- 294 Lyme disease spirochete
P75062 274 QLKQMQGndKKIKKIKWISPKQGSDNNSn-----lSIDDHKSG-----SFSSTEPRATTIINNLLDKGVSAIIPVAGPQv 343 Mycoplasma pneumoniae...
O29372 242 GCDVIAQ----HQDSPAAQQAAEERGVY-------SIGYHSDM-----SKFAPHAHLTSAVWNWSVIYSYVIEQVMQGT- 304 Archaeoglobus fulgidus
O32436 204 GADVVYP--AGDGYNVPVIQQIKKDGLY-------AIGYVTDQ-----SDLGENTVLTSTVQNVDKAYEIIAEQFNKGT- 268 Bacillus subtilis sub...
P0CL65 225 KVGVIFP--IAGITGLGVYDAAKELGPKy-----yVIGLNQDQ-----SYIAPQNVITSIIKDIGKVIYSISSEYINNRv 292 Borreliella burgdorfe...
P0CL55 209 GVDIIFA--AAGLSGIGVIEAAKELGPDh-----yIIGVDQDQ-----SYLAPNNVIVSAVKKVDSLMYSLTKKYLETGv 276 Borreliella burgdorfe...
Q45010 210 EIDIIHH--AAGLGGIGAIEVAKELGSGh-----yIIGVDEDQ-----AYLAPDNVITSTTKDVGRALNIFTSNHLKTNt 277 Borreliella burgdorfe...
Q45011 215 GIDVIHF--AAGLAGIGVIEAAKNLGDGy-----yVIGADQDQ-----SYLAPKNFITSVIKNIGDALYLITGEYIKNNn 282 Borreliella burgdorfe...
O05252 223 GVDVIYH--SAGATGTGVFTEAKNLKKEdpkrdvwVIGVDKDQyaegqVEGTDDNVTLTSMVKKVDTVVEDVTKKASDGk 300 Bacillus subtilis sub...
2FQW_A 188 GVNVIFQ--VAGGTGNGVIKEARDRRLNgqd--vwVIGVDRDQym-dgVYDGSKSVVLTSMVKRADVAAERISKMAYDGs 262 Treponema pallidum
4IIL_A 293 -LPSAGAWTLGVKDGYVRFI---------EEDPLYLQTVPEPIRVRQSALLRRIQSGELT 342 Treponema pallidum subsp. pallidum str. N...
O51298 295 -INYGNSDIFGIKHKGVLFN---------VSNVFYLERTSQKLKEDLLKKIEEVSANGIK 344 Lyme disease spirochete
P75062 344 nLAVNEVARRKAHTAIIGVDsa-----qeLLDINQDAPDKDQLIKGNKKIIPFSSIKALD 398 Mycoplasma pneumoniae M129
O29372 305 --WKSEQIWWGIDKGVVGLTplsdvvpedVKKMVEEEKQKYLNGEVPEQYPFVGPIYDQQ 362 Archaeoglobus fulgidus
O32436 269 --LEGGDHYYDLNTGVVEMG---------TFSPLVDQDFQQRIAKLIKTYNKTGELPKNE 317 Bacillus subtilis subsp. subtilis str. 168
P0CL65 293 -FKGGIIIDRGLKEGVIEIVk--------DPDVLNNRLVDEVIDLENKIISGEIIVPDSE 343 Borreliella burgdorferi B31
P0CL55 277 -LDGGKTMFLGLKEDGLGLVln------eNLKSNYSEIYNKSLKIGQSIMNGIIKVPYDK 329 Borreliella burgdorferi B31
Q45010 278 -FEGGKLINYGLKEGVVGFVr--------NPKMISFELEKEIDNLSSKIINKEIIVPSNK 328 Borreliella burgdorferi B31
Q45011 283 vWEGGKVVQMGLRDGVIG-----------LPNANEFEYIKVLER---KIVNKEIIVPCNQ 328 Borreliella burgdorferi B31
O05252 301 -FPGGETLTYGLDQDGVGIS---------PSKQNLSDDVIKAVDKWKKKIIDGLEIPATE 350 Bacillus subtilis subsp. subtilis str. 168
2FQW_A 263 -FPGGQSIMFGLEDKAVGIPe--------ENPNLSSAVMEKIRSFEEKIVSKEIVVPVRS 313 Treponema pallidum
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