8SSD,5C8E


Conserved Protein Domain Family
B12-binding_2
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pfam02607: B12-binding_2 (This model is not part of the current CDD release)
B12 binding domain
This B12 binding domain is found in methionine synthase EC:2.1.1.13, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of pfam02310. The structure of this domain is known, it is a 4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif.
Links
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Statistics
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PSSM-Id: 515052
Aligned: 580 rows
Threshold Bit Score: 31.3056
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8SSD_B          2 LLERLKRRVVEGRKQGLEADLEEALkaghK----PLDLINGPLLAGMKEVGDLFGAGKMQLPFVLQAAEVMKRAVAYLE 76  Thermus thermop...
WP_025281584   52 VVEEFSRMVIEHDAAAALAYVETLR----TqgtaLESVFVHLLAPTAKRLGELWEEDQADFTEVTVGLCRLQHVLRElg 126 Ectothiorhodospira
52_pfamImport   1 --DRLLDALLQFDESKAHDLINQAF----Sly-tIDKVLVDILGSLLVKIGDLWERGEITTAHEHFASSILRSRIGIIL 72 
11_pfamImport   1 LSDEILQALLSFEETKAHQLLNQAF----Smf-sIDKVTIDILGTLLVKVGYMWENNEISTAHEHFVTSFLRTKIGNI- 73 
WP_013488437   95 LRNDLLISLLEFDEQKSNQQLDQIF----Amf-sIEKIVIKILGELLIDVGDKWERGEITVAHEHFVTSYLRTKIGMVL 168 Evansella cellu...
WP_012574704   92 LRERLLRALLSFEEWTAHELLNEAF----Sly-tVEKVALDILSPLLVKIGDLWENEKITSAHEHFASAFLRSRLGMAf 165 Anoxybacillus f...
Q5WGW3         96 LATDFLKALLAFDEEQAQEWLNRAF----Smy-sMERVAIELFSIAYDMLEQERRQGTITLAHQQYAVRAMEAKITNLa 169 Bacillus clausi...
Q81FT0         96 LVDDLLQALLKFDEITIAALLNEAF----Siy-sTEKVVASIVLRVTDKLLTSKNNNEISMVQFQYALSFLQTRLGMVY 169 Bacillus cereus...
WP_004078472   21 dtDDMVAALIAVDRVRAGRIAEESC----Ghg-sPILCTEKLIMPALEEVGRLWESGELSLSQVYMSGRICEEIVDTIL 94  Methanoplanus l...
BAM02464       27 LLERFYTALISGDRAAAGEVLAECR----SgkatAEALANHLIWPTLDQVQKAHRNDQLSDLSYHFATRLMRSITDRLQ 101
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