4EHY


Conserved Protein Domain Family
LpxK

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pfam02606: LpxK 
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Tetraacyldisaccharide-1-P 4'-kinase
This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N-terminus.
Statistics
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PSSM-Id: 396941
Aligned: 111 rows
Threshold Bit Score: 274.052
Threshold Setting Gi: 500119657
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4EHY_A   2 LRSSLLPFSYLYEKIINFRNTLYdkgflKIKKLPVPVISVGNLSVGGSGKTSFVMYLADLLKDK--RVCILSRGYKRKSK 79  Aquifex aeolicus VF5
P58184  20 TRALLTPLSWLWADTTRRRIARA-----TPAIVGAPVICVGNVTMGGAGKTPIVRELLLTLTQRgvAAHGLSRGYGGKLK 94  Caulobacter vibrioide...
B0T114  20 TRALLTPLSWIWAAQTARRIART-----TPRGADCAVICVGNFTVGGVGKTPIVRELLLTLTKRgrRAHGLARGYGGKLK 94  Caulobacter sp. K31
Q0C4B4  22 TRLLLTPFAMLYLWALRRKLAKA-----RPEAAPVPVVCIGNLTAGGAGKTPVTEAIRNRIRSAglRAASLSRGHGGAEP 96  Hyphomonas neptunium ...
Q0AS12  19 ARALLAPLGWIHAWAVARRIRKA-----TPVRIGPKVVCVGNLTVGGTGKTPVTQTLMQRLAEMdlTAASLSRGYGGREA 93  Maricaulis maris MCS10
Q5FPH6  17 AARLLRPFSFIATTLTRRRLRQP------TFHASVPVLCCGNITTGGTGKTPLTLDLVQRLRDRghHPHILSRGHGGRER 90  Gluconobacter oxydans...
Q0BPW0  14 TARLLAPASALTAAFTAHRVARP------GWRAPVPVVCCGNATVGGAGKTTIALDLIARLKKRgfTPHALTRGYRGRVK 87  Granulibacter bethesd...
Q5LMW7  17 QSRLLAPLGALYARATARRLAKG-----DPVSVPVPVICIGNLNAGGTGKTPSAIWVAERLRDAghEPHVVTRGYGGTLE 91  Ruegeria pomeroyi DSS-3
Q1GD92  17 RACLLSPLGALYAKGTATRLRKG-----APTRAPVPVICVGNLNAGGTGKTPTVIWLMEQLGAAghEVHVVSRGYGGRLE 91  Ruegeria sp. TM1040
Q28VE6  14 ASTLLAPLGALYAAGTARRLRTG-----PRVRVDVPVICIGNINAGGTGKTPTAIALAQRLLAKgvKVHAVTRGYGGEVE 88  Jannaschia sp. CCS1
4EHY_A  80 GTLIVSEYGnlkvSWEEAGDEPYLMAKLLPhvsVVASEDRYKGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLL---- 155 Aquifex aeolicus VF5
P58184  95 GPVRVDTIRh---TAADVGDEPLMLAQDFP---MWIAADRVAGAKA-AVRAGASAIVMDDGHQNPSVKKALSLVVVdget 167 Caulobacter vibrioide...
B0T114  95 GPVRVEPSRh---TVAEVGDEPLMLAQDFP---MWVSRDRVLGARK-AAASGAEVVVMDDGHQNPDLRKTLSLVVVdget 167 Caulobacter sp. K31
Q0C4B4  97 GPLKVDPARh---TSRDVGDEPLLLAGSGE---AWIGRKRPEAARA-MAADGAEIILMDDGHQNPSLKKDLTLIVId--- 166 Hyphomonas neptunium ...
Q0AS12  94 GPLRIDPATh---DASTVGDEPLLLARTGQ---AWIARDRAAGGRAIEAAGGVDLVLMDDGHQNPDLAKDCSIVVVd--- 164 Maricaulis maris MCS10
Q5FPH6  91 GPIGVNPNRs---TPRDVGDEPLLLAQSAP---TWIGADRAETARLAIS-QGADCLVMDDGFQNPTLHQDVSVLVVd--- 160 Gluconobacter oxydans...
Q0BPW0  88 GVVQVQPDD----TVFQVGDEALLLAASAP---CWVAPDRAAAAREAIA-AGASVLVMDDGLQNPGLARDLSLLIId--- 156 Granulibacter bethesd...
Q5LMW7  92 GPVQVDPRRh---RAEQVGDEPLLLAAFAE---VWVAKDRAAGTRAAAA-AGASVIILDDGFQNPSVAKDLSIVVVd--- 161 Ruegeria pomeroyi DSS-3
Q1GD92  92 GPVQVDPRRh---SAADVGDEPLLMAAFGE---VWVARDRGAGVTEAAA-AGASVIVMDDGFQNPSVAKDFSIIVVd--- 161 Ruegeria sp. TM1040
Q28VE6  89 GPLCVEERTh---TAKQVGDEALLLSAFLP---TWVSTDRQAGARAAVA-DGAECLILDDGFQNPALAYDLSIVVVd--- 158 Jannaschia sp. CCS1
4EHY_A 156 ---KKKDLKDRLLPAGNLREPLK-EIRRADALVLtyqevepfe-------fftgkptfKMFREfccllnsdfEEVPFDIL 224 Aquifex aeolicus VF5
P58184 168 rggEWPFGDGRVFPAGPMREPLKvGLSRADAVIVllpvdveqpdfd-llvafgdmpvlVARLEa--------AA----PV 234 Caulobacter vibrioide...
B0T114 168 redEWPFGDGRVFPAGPMREPLNvSLGRTDAVIVllpadlpeadpr-llalfgdtpvlIARLEp--------AA----PP 234 Caulobacter sp. K31
Q0C4B4 167 --aGAPFGNGHVLPKGPLREKVPeGLARADAVILmgagpvppe------vtasslpvlRARLAp--------LA----AP 226 Hyphomonas neptunium ...
Q0AS12 165 --gLTGWGPGTIVPAGPLREPVAtGLARADAVIVmmpdaatepdwtglglsdlsipvfHAWLEp---------LAP---P 230 Maricaulis maris MCS10
Q5FPH6 161 --gVTGFGNGCVLPAGPLREPVPdALARAQAVVVmgddrhnlip-----tfpphlltaQARLVp---------GPEIRTL 224 Gluconobacter oxydans...
Q0BPW0 157 --gAVGFGNGRVLPAGPLREPVAaAAARCRAAVIvgddvtgtar-----qlpaglqvlRAHLT----------ATGTEAL 219 Granulibacter bethesd...
Q5LMW7 162 --aAQGFGNGRCIPAGPLREPVAtGLARADLVLAlgdaqaqeqfrd-twgaalsvplvTAELKp--------LRTGM-DW 229 Ruegeria pomeroyi DSS-3
Q1GD92 162 --aKRGFGNGRCLPAGPLREPVAtGLSRADLVLSlgdaraqetfqs-iwgaeipvphlTGHVEp--------LPTGM-PW 229 Ruegeria sp. TM1040
Q28VE6 159 --aWRGFGNGRVIPAGPLREPVEiGLKRADIVLSigpdaaqqrfat-twgrhiavphlTGTLQp--------LPTGL-PL 226 Jannaschia sp. CCS1
4EHY_A 225 KEREVIAFSGLGDNGQFRKVLKNLGIKVKeFMSFPDHYDYSDft--------pEEgeiYLTTPKDLIKLQgy--enVFAL 294 Aquifex aeolicus VF5
P58184 235 PKGPQVGFAGIAKPWKVEKALTAAGCQLVdFAPFPDHGAYSEstlkmladraeVYeagLVTTEKDWVRLppawrerVTPW 314 Caulobacter vibrioide...
B0T114 235 PKGRQVGFAGIGKPWKVERALKAAGCHLVdFAPYPDHGQYDEatlnflweraqTYsagLVTTEKDWVRLpqawrdrVTPW 314 Caulobacter sp. K31
Q0C4B4 227 PPGPLVAFAGIGRPQKFFDSLAQAGGNVSdAVPFGDHHPYTKgdvqflrslahDHgarLITTTKDHVRLpldaqseILAW 306 Hyphomonas neptunium ...
Q0AS12 231 PAGKLVAFAGIGRPEKFFDALRAAGGDIGeVAVYGDHHAFNAgdlrhldalaaAHdaqLITTEKDWVRLPvdiqarVTAW 310 Maricaulis maris MCS10
Q5FPH6 225 QGRRIVAFAGIGRPEKFFDMLRDAGVAPIrSLPFPDHHFYTPrdiqrlealsrESgttLVTTAKDAVKLPfpfrtqVKVI 304 Gluconobacter oxydans...
Q0BPW0 220 IGRPVLAFAGIGRPAKFAETLTRAGVEVVeLRGFPDHHVFTErdltllaqdaaAMgavLVTTPKDAVRLRsdwqkrVTVS 299 Granulibacter bethesd...
Q5LMW7 230 AATPVLAFAGIGNPAKFFRTLRAEGADLRrAEALDDHQPLTPalmtrlenearLLgaqLVTTEKDAVRLppafrskVITL 309 Ruegeria pomeroyi DSS-3
Q1GD92 230 QGTKVLAFAGIGHPEKFFATLRGLGAELCrAEALEDHQTLAPalltrleqearLLgaqLVTTEKDAVRLplsfrpkVITL 309 Ruegeria sp. TM1040
Q28VE6 227 DGLPVLAFAGIGHPEKFFQTLRSLGADLHaTHALADHQPLTDtlmirllrdasMRgaqVVTTEKDAVRLspefraqVMTV 306 Jannaschia sp. CCS1
4EHY_A 295 NFKVKLerEEklkklIYRIFY 315 Aquifex aeolicus VF5
P58184 315 PVRARFedPAalealLKGIGL 335 Caulobacter vibrioides CB15
B0T114 315 PVRARFedEGalgalLESVGL 335 Caulobacter sp. K31
Q0C4B4 307 PVTAVFedTAaldavLAPIFK 327 Hyphomonas neptunium ATCC 15444
Q0AS12 311 PVRAVFanPGaldglLRDVMD 331 Maricaulis maris MCS10
Q5FPH6 305 GVELLWadPKsperlLDLLFS 325 Gluconobacter oxydans 621H
Q0BPW0 300 GVRIVWedEQaldrlLDTLPT 320 Granulibacter bethesdensis CGDNIH1
Q5LMW7 310 PVRLEVaeEDrlraiLLAAAP 330 Ruegeria pomeroyi DSS-3
Q1GD92 310 PVRLRVaqGDtllarL----K 326 Ruegeria sp. TM1040
Q28VE6 307 PVRLEVddWGpldsaVDKVLG 327 Jannaschia sp. CCS1
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