1KNX


Conserved Protein Domain Family
Hpr_kinase_N

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pfam02603: Hpr_kinase_N (This model is not part of the current CDD release)
HPr Serine kinase N terminus
This family represents the N-terminal region of Hpr Serine/threonine kinase PtsK. This kinase is the sensor in a multicomponent phospho-relay system in control of carbon catabolic repression in bacteria. This kinase in unusual in that it recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller. The blades are formed by two N-terminal domains each, and the compact central hub assembles the C-terminal kinase domains.
Statistics
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PSSM-Id: 515048
Aligned: 265 rows
Threshold Bit Score: 60.1181
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KNX_A           6 VKELIEQFQdcVNLIDGH-TNTSNV-IRVPGLKRVVFEMLGLFSS-QIGSVAILGKREFGFLSQKTLVEQQQILHNLLKL 82  Mycoplasmoide...
WP_242825050    14 LDDFCREIK--LEKIY---YQSDEVdLIGSGINRPGLQLHGYYEHfDANRVQVIGKVEIAYLLDLDPEVRKQKIDDFFSY 88  Acetobacteriu...
WP_011986920     4 VKNLIKDME--LEVLV---EGLENNiIDVSDINRPGLQFSGFYNYfANERVQVVGKTEWSFLDVMKKELRIKRLNKFFEF 78  Clostridium b...
jgi:Clopa_1832  13 VKTLVEDLG--LEVII---SGPEEAeVCLSDINRPGLQFAGFYSYfANERIQIVGKTEWSFLDEMRSEIRKKRLKKFFQF 87 
WP_014261856    12 IKQMIVDLN--IDIITMP-EDM-DYtLYTSDINRPGIQLAGFYGYfPSDRIQIIGQVEYAYLMSLNENAQKEVLEKYLSY 87  Filifactor al...
CBH20674        21 IRKIIEDLK--VGVAYIP-DGV-DYhISTTDINRPGMQLNGYYDHfPNDRIQVMGKVEYSYYLSLDEETKKERMDKYMSY 96 
29_pfamImport    3 VKNLIEDLG--LKVLTGKlEAAKEIyITEKEVNRPGIQLAGYFDYfTPERIQVIGKTEYTFFGSFSTEHREKALGEYFSY 80 
Q180Q7           9 IREIIKELK--LKVVYMP-DDV-DYyVYSQDINRPGLQFAGYFDYfAYERIQIVGKTEYNFFGLMDSHIREEVLDRFFSY 84  Clostridioide...
41_pfamImport    3 ISDIVRDLE--LNVVYQP-EGK-EFfVKSQDVNRTGLALAGYFEYfAFDRIQIIGKGEYTYFKNIDKERRRQILDKLFSY 78 
Q93SG0           9 VSMFIKELE--LEVVHKG-ENT-DYeIISSDINRPALQFAGFFEHfAYDRVQVIGKGEHDYFGTLDRATRLRRLEKLFSY 84  Peptoclostrid...
1KNX_A          83 NPPAIILTKSFTDPTVLLQVNQTYQVPILKTDFFSTELSFTVETYI 128 Mycoplasmoides pneumoniae
WP_242825050    89 PFPCFIVCWDLDETYLFEEASKKYGRTLLKSKKHTTSLFYDLVNYI 134 Acetobacterium woodii
WP_011986920    79 KTPCTIITRNLAAHDEFINSAKEKGQWVLRTGEISTRFVSSLMSYL 124 Clostridium botulinum
jgi:Clopa_1832  88 ETPCIIIARNLTPHEEFIEEATRRNAWLIRASSTTTRFISKVMNYL 133
WP_014261856    88 RMPAIFMTRGQKPSESFVKIAKKYNQYLLISELSTKQLVNKLVTYI 133 Filifactor alocis
CBH20674        97 DLPVVIVARAQIPDDIMINAARKYNRIILTTPMGTTKFIYKLLDYL 142
29_pfamImport   81 DIPIIIVTRGMELREDFSKFAKASDIIVCSTESTTTRFINKLSSYL 126
Q180Q7          85 EIPALIISRDLEIKPDVIEKAKKYKRILLSTNRNTTRLINRLSNYL 130 Clostridioides difficile 630
41_pfamImport   79 DIPALIVTRGLKIDDDILDAAKRHGRVLISSERNTTRFINKISNYL 124
Q93SG0          85 EIPVLVLARGLDFSSDTINMAKKYNRIIIRSQMSTTKFINKASGYL 130 Peptoclostridium acidaminophilum
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