Conserved Protein Domain Family
Exonuc_VII_L
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pfam02601: Exonuc_VII_L 
Exonuclease VII, large subunit
This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.
Links
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Statistics
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PSSM-Id: 396936
Aligned: 455 rows
Threshold Bit Score: 165.3
Threshold Setting Gi: 123278008
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q21PB7         141 INRNRYLDKPKDFCRVAVVSPESAAGLGDFKTiaDRLEKYNLCKFNYYPSLFQGANAVASIVSAIsqvvvdi-engnqyD 219 Saccharophagu...
jgi:Fluta_1521 138 LNANQQIEMALVPKRLAIISQADSKGYSDFVTllNGHPKRYHFNTFLFEAALQGDNAIASIKGQLkriee----ikhhfD 213 Fluviicola ta...
jgi:Sph21_1456 143 FEANKLLPFPLLPKRIAIVSVETSKGLADFLKiiDHNSFGYRFEYELFPALLQGEKSVISIIDQLakirl----qlqrfD 218 Sphingobacter...
CCY35681       138 LDMNGTLPMPRLPRRFALITSETAAGYGDFMHhlYDNGYGFRFYTRLYQAPMQGSTAPGGIIAALdaimadv-dagevyD 216 Alistipes sp....
jgi:Marpi_0363 138 rtaNNTLEMLPPIKKIAVISSETAAGYGDFVKniNKTKYPP--LIHLYPSPMQGVEVPVGIISALknilk----skidyD 211 Marinitoga pi...
WP_011994716   150 EVLHNLDELEPI-KYIAVITSKTAQGYFDFLSniLVPDELR-PVIHLYESSMQGATTAEEVISALnrietfcrefmvkyD 227 Fervidobacter...
WP_012238030   250 LDRNRSLPFPALPLRVGLVTSLGSDAYNDVLG--TFRESGFAFRVVAHGVRVQGRQTEPSVLNALdyfra----raaelD 323 Sorangium cel...
WP_014546966   140 LEKNKQLELADVPLRVGLITGENTAAYKDFTTrlEASP--FAFEVTTIYARMQGNETEDSIIAALeqlqs-----dsnlD 212 Fibrobacter s...
WP_012468323   138 FETNKERFVPILPIRLGLITSSGSAAYNDFIQtlTASGYGF--KIYLADAMVQGDQTEKSVLRALdalt------gldvD 209 Geobacter lov...
jgi:Ppro_1869  143 FQPNKECFVPLLPQNIGLISSFGSAAYNDFIQtlTTSMFGF--KIHMADAMMQGEQTEKSVLRAMdalc------klgvE 214 Pelobacter pr...

Q21PB7         220 ALAIVRGGGDKAGLYQLNEIKIARCICRS---PIPVLVGIGHERDSTILDEVANCRLATPSLVASFIQ-------EAIvk 289 Saccharophagu...
jgi:Fluta_1521 214 AVVIIRGGGGEVGMHCYNNYELAKAIATF---PLPVLTGIGHSTNLTVCEMIAFRNGITPSDMAYFLL-------SIFee 283 Fluviicola ta...
jgi:Sph21_1456 219 VVAIIRGGGGEVGLSSYNNVLLAKAIATF---PIPVITGIGHATNETVSELVAYKNAITPSALADYLL-------QHFhn 288 Sphingobacter...
CCY35681       217 AVLLLRGGGAVADLVCFDDYDLAVNIAQF---PLPVMVAVGHERDTHICDMVAAISVKTPTALADYIV-------NAFie 286 Alistipes sp....
jgi:Marpi_0363 212 LVVIIRGGGSQADLMYFDDFNLAQHIAYFsnnKIPIVTGIGHEQDTTILDFVSYIRFSTPTEVARAINnq----iEFF-- 285 Marinitoga pi...
WP_011994716   228 VIVIIRGGGGPSDLMYFDDYNLARRIAQMn-nFIPVLTGIGHEKDETIPDFVAWRRFPTPTAVAKEISnqikgyqDKV-- 304 Fervidobacter...
WP_012238030   324 VLLICRGGGSRTDLAWFDSEPIARAVATF---PLPVVVGIGHERDISALDFVGFRE-KTPTAAAAMLV-------QRVs- 391 Sorangium cel...
WP_014546966   213 VVCIVRGGGAKTDLNFFDSEALCRAVANY---PTPVFTGIGHEIDRCLLDEVAYLSCITPTDCAKRLV-------ERVtd 282 Fibrobacter s...
WP_012468323   210 LVLILRGGGSKTDLYFLDNEAISRKIAGY---PKPVWTGIGHEIDTSILDYIANRSFKTPTAAAEELV-------ARFvq 279 Geobacter lov...
jgi:Ppro_1869  215 LIVIARGGGSKTDLYFLDNEAVARKIAAC---TIPVWTGIGHEIDTSVLDYVANKSFKTPTAVAEELV-------ARFiq 284 Pelobacter pr...

Q21PB7         290 nardakfnyel----------------------lvrssqsissfaKQELRDYRA-------------------------- 321 Saccharophagu...
jgi:Fluta_1521 284 ldapldealmk----------------------lpkqiqhllqesKNQFGQLTL-------------------------- 315 Fluviicola ta...
jgi:Sph21_1456 289 farpvtyaeqvlrlktrqlfdnqqqllnnniryfrmaslnmlhenKHQLANLRN-------------------------- 342 Sphingobacter...
CCY35681       287 --------------------------------------------eDASLTAIGD-------------------------- 296 Alistipes sp....
jgi:Marpi_0363 286 ---------------------------------------------HQTLHEKFQ-------------------------- 294 Marinitoga pi...
WP_011994716   305 ---------------------------------------------ERNVSDLSR-------------------------- 313 Fervidobacter...
WP_012238030   392 --------------------------------------------------dARD-------------------------- 395 Sorangium cel...
WP_014546966   283 --------------------------------------------sWNRMTEAMA-------------------------- 292 Fibrobacter s...
WP_012468323   280 --------------------------------------------mRRQLDEATNtlktvwayrlkidqdylaravtgiqq 315 Geobacter lov...
jgi:Ppro_1869  285 --------------------------------------------mQRQLEEASNtlqtvwayrfkidreyldraiigihq 320 Pelobacter pr...

Q21PB7         322 ---NISLLSHK----------------KLesarrqvtehntslthvpnlliQNAK--RQneenyiniklfsgrsiqqake 380 Saccharophagu...
jgi:Fluta_1521 316 ---TFKQEVQA----------------VLlseknafhgivkdfefqvkhkmTYSN--QV--------------------- 353 Fluviicola ta...
jgi:Sph21_1456 343 ---RTLQQSKY----------------QLiqekgsfqrlksqlstqskrtlMEEK--QA--------------------- 380 Sphingobacter...
CCY35681       297 ---RLRSSVTL----------------RLdgm------------------------rqR--------------------- 312 Alistipes sp....
jgi:Marpi_0363 295 ---NIIYEINS----------------NFttteiklknlsenlsiyfnnitKNQEnyLKemsnkinninkffemnekaln 355 Marinitoga pi...
WP_011994716   314 ---YMENAI-EllnaklsdtnyktvkeIFrgkiqsveeelidsaevlykrfSLKEyeKM--------------------- 368 Fervidobacter...
WP_012238030   396 ---EVESSLLS----------------ILdqg------------------------rrV--------------------- 411 Sorangium cel...
WP_014546966   293 ---SIADGARD----------------LLten------------------------nkQ--------------------- 308 Fibrobacter s...
WP_012468323   316 gprKLLDVTAS----------------CLreqaqelrarvqrrlsteqigiGRRR--EK--------------------- 356 Geobacter lov...
jgi:Ppro_1869  321 gprKLLEVTVS----------------NLreqaqdlrhlvserlstehiqlESKR--SQ--------------------- 361 Pelobacter pr...

Q21PB7         381 lvsesfrsaindtkvnirsigshIQ-----QLK--------IDvirR------------------------------AHH 417 Saccharophagu...
jgi:Fluta_1521 354 -----------------------LT-----QLR--------NQirsS------------------------------SGY 367 Fluviicola ta...
jgi:Sph21_1456 381 -----------------------IT-----FLG--------QRlkrE------------------------------NLH 394 Sphingobacter...
CCY35681       313 -----------------------LE-----QTA--------RRlgsG------------------------------ADM 326 Alistipes sp....
jgi:Marpi_0363 356 srldfinlisnhinnklinfssvIN-----------------------------------------------------NE 382 Marinitoga pi...
WP_011994716   369 -----------------------ISmdfikNL----------------------------------------------SE 379 Fervidobacter...
WP_012238030   412 -----------------------LR-----SASsdlt-rraARvprS------------------------------ASL 432 Sorangium cel...
WP_014546966   309 -----------------------LG-----TMG--------NQlqqK------------------------------VFG 322 Fibrobacter s...
WP_012468323   357 -----------------------LR-----SLPltltknhmERlaaKrqelssgvthcltrtgetlsglkqrfekerFLR 408 Geobacter lov...
jgi:Ppro_1869  362 -----------------------LK-----SLPlaviqkqiERlssKkqnigtqvkfalsgwtgtmsrlkgrfdknrYIK 413 Pelobacter pr...

Q21PB7         418 --STSTA-KSS---------------VQHYNIQMRQGASNsahqakssvlykyeeslkatkyyLGQQRNAieneskslrv 479 Saccharophagu...
jgi:Fluta_1521 368 --FFESQ-KNK---------------RENLINLLQIHSKs----------------------iLNSSLQTinnqqnqlir 407 Fluviicola ta...
jgi:Sph21_1456 395 --LSKRS-RQV---------------IRQIRDQLIRQSHq----------------------iAKKHHAAlttlhknlap 434 Sphingobacter...
CCY35681       327 --RCRLE-RNR---------------MDMLLMRMRKGVTLrsgnaqns---------lnilwmrvKSGTAlrlkaes--- 376 Alistipes sp....
jgi:Marpi_0363 383 knLIQKNmENK---------------LNM---SFQRid------------------------------------------ 402 Marinitoga pi...
WP_011994716   380 --KMKYD-ISEfskklmldykylkdtLEL---KINN-----------------------------INQQVerytkls--- 421 Fervidobacter...
WP_012238030   433 --LIARR-AGQ---------------LQEAVRQLRQGARr----------------------dLDAASHRvdemasllgp 472 Sorangium cel...
WP_014546966   323 --LIQNE-KSK---------------HVLIAASIKKDTAf----------------------yIKSEHERlnrnqeglkq 362 Fibrobacter s...
WP_012468323   409 --RLAVE-RER---------------NEKNRQQLKARFFs----------------------vFKMKYMLltnikgrlkq 448 Geobacter lov...
jgi:Ppro_1869  414 --RLQVE-SDA---------------HDKSSQQLLSRFTa----------------------aVKLLTMQqwnrkerfrv 453 Pelobacter pr...

Q21PB7         480 naa-qsltaiksdikilVERVLLL------------DP-SKILAKGFALIMSNeKKVLTTKKDVLKQKNVSLRLKDGFVE 545 Saccharophagu...
jgi:Fluta_1521 408 ffp-rrfetetknleqaELHLNLL------------DP-ITILQRGYAIVT-NqKGVLSAKNQAKAGEELKIVTEAQELN 472 Fluviicola ta...
jgi:Sph21_1456 435 gik-rllveatksldnqERHLSIL------------DP-QHVLKRGYSIML-FqGKAVTDAQVLKVGDKVKTILAFGETD 499 Sphingobacter...
CCY35681       377 -----------grldmlELRIRKG------------DP-VAMLRPGSAYVL-RaGRPVESSADLVPGDSLDLLLRDGTAR 431 Alistipes sp....
jgi:Marpi_0363 403 ---------------elYIKITQN------------SPfSAFLSNGAIVIQn--GEIVNTIKNLKI-DPVEIKFKDGEAK 452 Marinitoga pi...
WP_011994716   422 -----------dtlekeYSNLSNLveekkeefvkigGP-LSALSFGGAVVLKg-RKIIQSKKELSTGENVIINFIDGKAQ 488 Fervidobacter...
WP_012238030   473 rss-rrlaleserlesrERRLRLL------------DP-RRVVERGYAILRTTeGAVLTDAARAPQGTTLIAELKRGVLr 538 Sorangium cel...
WP_014546966   363 gsr-kildlaksqfelvSEKVKNA------------DP-KTTLAKGYSLTLDEnGKFIRKASQLKSGDTIKTRLADGDVL 428 Fibrobacter s...
WP_012468323   449 ervlqrialartslndkmatLKAI------------DP-QTVLKRGFALVYSQqGTLVRSIADVAEKQLIQTRLADGSLI 515 Geobacter lov...
jgi:Ppro_1869  454 ekvkqrimverkslndkmatIRAT------------DP-QNALQRGFALVYRQdGQLIRSIHDINKSDTIRTHVVDGTVI 520 Pelobacter pr...

Q21PB7         546 AH 547 Saccharophagus degradans 2-40
jgi:Fluta_1521 473 AK 474 Fluviicola taffensis DSM 16823
jgi:Sph21_1456 500 SQ 501 Sphingobacterium sp. 21
CCY35681       432 cl 433 Alistipes sp. CAG:831
jgi:Marpi_0363 453 Gk 454 Marinitoga piezophila KA3
WP_011994716   489 AT 490 Fervidobacterium nodosum
WP_012238030   539 lr 540 Sorangium cellulosum
WP_014546966   429 sv 430 Fibrobacter succinogenes
WP_012468323   516 SE 517 Geobacter lovleyi
jgi:Ppro_1869  521 SE 522 Pelobacter propionicus DSM 2379
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