4RG1


Conserved Protein Domain Family
Methyltrn_RNA_3

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pfam02598: Methyltrn_RNA_3 (This model is not part of the current CDD release)
Putative RNA methyltransferase
This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA, and may function as a methyltransferase.
Statistics
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PSSM-Id: 515043
Aligned: 141 rows
Threshold Bit Score: 172.762
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RG1_A        11 TLSVALPGSILD--NAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGQDA--KTVEGEFTG------------------ 68  human
Q6C565        44 SVTLVVPSTCISetVVKSYQQAVHTAYQIARAAVAYNVDEIVIYEPSERPDikQEKTKKSETssfgkpkiv----fnsda 119 Yarrowia lipoly...
XP_056088041  39 QYSICIPTSAID--NCFNLEQTTFTAYQIAKTAVLFNIQEIIVLDLSKDRR-----HGKRPR------------------ 93 
P53336        39 KYSICIPTTVID--NCNNLEQVTFTAYQIARTAVLFNVQEIIVLDQSKDKK-----HEKKSR------------------ 93  Saccharomyces c...
Q751R3        60 NYTLCIPTSILD--NCANLEQVTHALYQIAKAATLFNVGEIVVLDLGTDTDaaAPHLAASELeprkrkikfedvtektet 137 Eremothecium go...
XP_003684072  54 NYSICIPTSITD--DCKNLEQTTNVIYHIAKTATIFNVGEVIILDLGKETP-----IEVTEDikgt-------------- 112
XP_004357789 182 TRSIAIPNDILD--DFASEEMKTYLVEMIARTLVLFSIDEVIVYRSTKSTNs---------------------------- 231
Q54LQ0       161 TVSIAIPSNALS--GIQSEEMKTYIIEMISRQVTMNKIDEIIVFKTDDYNEedSQQQ----------------------- 215 Dictyostelium d...
XP_003286192 171 TVSIAIPSDCLK--DIESEEMKTYVIEMISRQVTMNKIDEIIVYKTDDYDDtdNTQQ----------------------- 225
O13641        17 TISLALPISSLN--VAYNLQLKTSFVWKISRIVSLYGIDEIILLEDPEYVQntQVHTLSSD------------------- 75  Schizosaccharom...
4RG1_A        69 ----VGKKGQACVQLARILQYLECPQYLRKAFFP---KHQDLQFAGLLNPLDSPHHM-----RQDE-ESEFREGIVVDRp 135 human
Q6C565       120 sndhKPELSERAVTLASLLQFFVTPDYLRKSIFTpetTTTNFEYAKKLPKL-LLPFMes-------rDARYKEGMSIPMi 191 Yarrowia lipoly...
XP_056088041  94 ----SKETISDCLLLATLLQYFVTPSNLLDITFKr-kNMLYLKHAFAFPKLHQLAFM------NESaEHIYREGLSIAQd 162
P53336        94 ----SKETISDCLLLATLLQYFVTPPNLLDTTFKk-kNKLYLKCASTFPPLNQLPFM------NASaEQHYKEGLSIARd 162 Saccharomyces c...
Q751R3       138 snkkSASRLSGAMLIATLLQYFVTPRYLVSSVFKk-kYSSYFNCAAKLPRLSALPFMrh----lqTdQGRYREGLSVNMa 212 Eremothecium go...
XP_003684072 113 -kgeTKKRLSRPMLIATLLQYFVTPPYLVNTVFKk-dYHKYFKYACKLPRLSVLPFMry----yeEdKGRFREGLAVRMs 186
XP_004357789 232 ----------TTDKLCKLLEFIDLPKNIRHHLYDl--NDIDYQFVDKLKRVESGQHA-----TSNR-WTKYREGIVLDKl 293
Q54LQ0       216 ---------SDLNLLLKVLEYIETPSYLRDELFNt--LEKDYFNVDKLNSINSCQQ------QQPNdEQLYREGVVTNQh 278 Dictyostelium d...
XP_003286192 226 ---------SNLNLLLKILEYIETPSYLREELFNt--LDKDFFYVDKLNRLNSTQE------EVNAdDKLYREGVVTDQq 288
O13641        76 -----AYLKDPTKFLTDLLCYFETPFFMRKELFP---LNPHLKYTSCFPLLP----LrndkaSTVNiEFPYREGIVTHPs 143 Schizosaccharom...
4RG1_A       136 TR---------PGHGS-----------------------------FVNCGm--KKEVkIDK----NL-EPGLRVTVRLnq 170 human
Q6C565       192 LN---------KNVKSkiskqkrnvkkaeakgielqpptvdgatpYINIG---AAEP-HELeygqTV-PVGVRVTVDT-- 255 Yarrowia lipoly...
XP_056088041 163 NA---------EKE-Ierd-----------------------qtnLVYIG---KGEI-IELsn-qNI-PRTVRVTVDL-- 201
P53336       163 SS----------KGKSdda-----------------------ltnLVYIG---KNQI-ITLsn-qNI-PNTARVTVDT-- 201 Saccharomyces c...
Q751R3       213 KP---------AAAKKpst-----------------------rtkYINIG---KDTM-LELrs-qQV-PVNVRVTVDT-- 252 Eremothecium go...
XP_003684072 187 KPeatnsnqsnSKKAKefk-----------------------qtkYINIG---KSEC-LELks-qLV-PVNVRVTVDT-- 235
XP_004357789 294 SG---------KFS-------------------------------LVDVGlgdGKEIkIDK----EL-QAGIRVTLEMee 328
Q54LQ0       279 WK---------NQS-------------------------------IVNVGl--EKLVlIPK----RL-NPGTRLTIDIkn 311 Dictyostelium d...
XP_003286192 289 FR---------NQS-------------------------------IISVGl--EKQVlISK----RL-NPGTRVTIDMkq 321
O13641       144 PQ---------AKNKY-----------------------------IINAGl--SHNViVSSp---SVlAPRTRVTVRLka 180 Schizosaccharom...
4RG1_A       171 qqh---------------pdcktYHGKVVSSQDPR---TKAGLYWGYTVRLASCLSAVFAEAPFQD--GYDLTIG-TSer 229 human
Q6C565       256 -----------------------KENKVVSATEAY------GQDTGYSVRVATDFSHIFTMPSTPE--GYDYTVWcPGge 304 Yarrowia lipoly...
XP_056088041 202 -----------------------QRKEVVSPRDVY-----KNQTLGYHVRVASTLDEV------SE--GYARTLWvNSgd 245
P53336       202 -----------------------ERKEVVSPIDAY-----KGKPLGYHVRMASTLNEV------SE--GYTKIVWvNSgd 245 Saccharomyces c...
Q751R3       253 -----------------------VNKNVVSPAEAYgdySGANAAYGYSVRVARTFADIFLGAGFAG--GYTQSLWvNSad 307 Eremothecium go...
XP_003684072 236 -----------------------VEKRVVAPQEAYgdyVGAQSSFGYHVRVCKKFGSVFTESAFPE--GYSQAIWcNSgd 290
XP_004357789 329 ehgkq-----------innanqhRKGKVVSPAEVR----HDGHYWGYQVRSVDSIDNVFQDSSFn---AYDYKILfTCns 390
Q54LQ0       312 ssngdddgtggggdgnretndkyINGKIISPSDIK----KEGYYWGHHIRLVDSLAKVASTCQYEDtqNYDYIIM-HSqy 386 Dictyostelium d...
XP_003286192 322 enfteeels----kiinttdeqyTLGRVISPQNIK----KEGYYWGHHVRLVNSMDEIASTCEYKDtkTYDYSIL-LSdf 392
O13641       181 qsp---------------neegqLQGDIVSFSAPR---EKGGHYWGYKVRSCLS-SQLCKSSPYKG--GYDFVVQiNSqt 239 Schizosaccharom...
4RG1_A       230 ----------gsDVASAQLp----------------------NfRHALVVFGG-LQGLEAGA------------------ 258 human
Q6C565       305 frqselapetqpKPILALPrt----------------------vKRPLFVFGQ-WDHVEDAV------------------ 343 Yarrowia lipoly...
XP_056088041 246 yhyde-elskyrKVETKLPyimkikk----------gsvsetP-CNILLIFGK-WDHLKRCF------------------ 294
P53336       246 fhyde-elskyhKVETKLPyiaklkk----------sstsekP-CNILLIFGK-WGHLKRCF------------------ 294 Saccharomyces c...
Q751R3       308 fffdp-aaqssvRLDSKIPhvqkiikpsl---eelheqpsvqP-ANLLLVFGK-WKHLSDKF------------------ 363 Eremothecium go...
XP_003684072 291 yyyne-klkkndSIENELPriqsivksekktsengdetpaaqM-SNLLVLYGK-WKHILESF------------------ 349
XP_004357789 391 hdnqevqdlkqqRLKEKQDifdn---------------nlesQ-QHVLIIFAErEQQILDLLkqlpiekedekeedened 454
Q54LQ0       387 geqfpsy--------------------------tdvvinnakKyNHLLVIFAD--ANASSTV------------------ 420 Dictyostelium d...
XP_003286192 393 geqfpsp--------------------------tdpmlnnakRyNHLLIIFANnHKKF---------------------- 424
O13641       240 s---------aiTSKELEAsl-------------------psSfRHAVLVLQDnVVQKELVD------------------ 273 Schizosaccharom...
4RG1_A       259 ----Dadp------nleVAEPSVLFD----LYVNTcpg--qgSRTIRTEEAILISLAAL 301 human
Q6C565       344 ----Khdt------algVSGAKELFD----SKVDF-------KRPVRVEDGVFVALDRL 381 Yarrowia lipolytica
XP_056088041 295 ----Krsd-------leCSALHRYFS----GQLHFpgt--vpQGKLAIQDGLQIALTML 336
P53336       295 ----Rrsd-------leSSSLHHYFS----GQLQFpas--vpQGNIPIQDSLPIALTMF 336 Saccharomyces cerevisiae S288C
Q751R3       364 ----Qqtkd----qfdgASGAHDLFD----GRLDLpg---apEGYICIEDSCMVALATL 407 Eremothecium gossypii
XP_003684072 350 ----Easke----mfegCSGPHEFFD----GQLELpga--apRGMIPISDCCTISLTLL 394
XP_004357789 455 keeeKke---------dGEKKEKKLDksldKIIDLqsdntlkSKRVRFEETLLIGLSSL 504
Q54LQ0       421 ----NpefklgsevlvpDTHINTLVD------FNI--------KKLRFEETLSITLSKL 461 Dictyostelium discoideum AX4
XP_003286192 425 ----NpadrlnsevlipDTHINTLFN------FNNv--------pIRFEENLFVTLSKL 465
O13641       274 -----------------STAKSISFNpfpvSFLNDpi----------pEEILLAAMTRL 305 Schizosaccharomyces pombe 972h-
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