Conserved Protein Domain Family

pfam02591: zf-RING_7 
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C4-type zinc ribbon domain
Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues. This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles. Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns, an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4).Structural modelling suggests this domain may bind nucleic acids. The domain appears to bind flaA-mRNA, thus contributing to flagellum formation and motility.
PSSM-Id: 396927
Aligned: 184 rows
Threshold Bit Score: 34.0095
Threshold Setting Gi: 18202759
Created: 20-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
5Y06_A         223 RCGACRIEIDRGEIARITAAadddVVRCPECGAIL 257 Mycolicibacterium smegmatis MC2 155
jgi:Ctha_2112  224 ACSGCNTRVPTNRHAFILQGg---FYSCETCGRIV 255 Chloroherpeton thalassium ATCC 35110
WP_012447676   202 VTCACGLELSTERYSRLQVEg---MVSCDSCDRIV 233 Natranaerobius thermophilus
BAM31521       198 ACGGCFMKLNDTIYNEIIKGs--dIINCPHCGRIL 230 Helicobacter cinaedi CCUG 18818 = ATCC BAA-847
WP_006656360   198 ACGGCFIRINDKIYSDVIRSd--dIITCPHCGRIL 230 Helicobacter canadensis
CBG40599       198 ACGGCFIRINDRVFAEVKQSn--dIVNCPHCGRIL 230 Helicobacter mustelae 12198
WP_013889722   198 ACGGCFIRINDRTYAELLSSg--dILTCPHCGRIL 230 Helicobacter bizzozeronii
O25612         198 ACGGCFIRLNDKIYTEVLTSg--dMITCPYCGRIL 230 Helicobacter pylori
jgi:Arnit_2515 198 ACYGCFMKISDQTYAEIIKSe--eIINCPHCGRII 230 Arcobacter nitrofigilis DSM 7299
WP_012147875   198 ACYGCFMKINDKTYAEVLRGe--eIVNCLHCGRIL 230 Arcobacter butzleri
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