5KO9,2BDV


Conserved Protein Domain Family
SRAP

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pfam02586: SRAP (This model is not part of the current CDD release)
SOS response associated peptidase (SRAP)
The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human abasic site processing protein HMCES, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.
Statistics
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PSSM-Id: 515035
Aligned: 357 rows
Threshold Bit Score: 144.988
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KO9_A         1 MCGRTSCHLPRDVLTRACayqdrrgqqRl----P---------------------------------------EWRDPDK 37  human
CDF80831       1 MCFHTATTSKTKRLDKHF---------Gv----Kls------------------------------------aEDVRSIF 31 
WP_013870909   1 MCFHKSLTKKQEEFKERF---------Da----A---------------------------------------M-KELDV 27  Lacinutrix sp. ...
WP_015481161   1 MCVHTSLTKSAKAIEKKT---------Kk----E---------------------------------------F-TTPQL 27  Polaribacter sp...
CCE80833       1 MCGRYALGVNLNELPQQF---------IqsaitPfsgrqsnyhldqehstgd---nytfnagdkesgdsleveVNRANGD 68 
XP_006684149   1 MCGRYAMTVDVQQLPSQF---------TrtalrRedpgssntddvkkvtent---ysttethfngseenvkifVMNGLEG 68 
XP_036664006   1 MCGRFAQRINPNSIPSEF---------Yet-vfGeetsdinepstgvye---------tdvheandkvekvqlDLTRVSQ 61 
Q6BHR8         1 MCGRYALGININELPQQF---------NetvlnRsntnvqysikqlsdtnyeavdesndeatsnhanrieimiLNLSNQT 71  Debaryomyces ha...
XP_013933018   1 MCGRYSMSFAPGELPAQF---------Aq---qNln-----------------------------------idRIEDADL 33 
WP_014264679   1 MCGRYYNKRKKQKIAEKL---------Q-----A---------------------------------------SKVFADP 27  Granulicella ma...
5KO9_A        38 Y-CPS--YNK-SPQSNSPV----Ll-sRlhfekdAd--SSERIIAPM----RWGLVP---------SWF--K---ESdps 88  human
CDF80831      32 D-TPQ--YHLnGFTHPNML----VipqQ------K----PE-VLAPG----VWGIVPytktpdqinPYY--K---EAv-- 82 
WP_013870909  28 Y-EPYfhRSG-FEDNYIYI----Ik-aN------E----PY-DIVPS----YWGIMP---------ENY--N---IYq-- 69  Lacinutrix sp. ...
WP_015481161  28 F-QPYfhFNG-WESKNLAI----Tt-qE------A----ST-QIAFA----KWGVLP---------THY--D---VSy-- 69  Polaribacter sp...
CCE80833      69 F-TKT--YNI-APTKTAVI----Iy--G------R---KEEGKTKYIietsTFGLLP---------VWAgkN---NEdta 117
XP_006684149  69 Y-RQS--YNV-APTKNELI----Iy--K------Qy--SAANNVEYImetsGFGLVP---------NWSkpG---NTd-- 116
XP_036664006  62 W-TPS--CNI-APTDTALM----Vy--M------Te-pTKDITQNYViepsKFGLVP---------SWAkpV---DSt-- 110
Q6BHR8        72 F-QSS--YNI-PPTRTALI----Iy--Q------AknsDATFKNRYVieslTFGLVP---------SWAkpK---DPt-- 121 Debaryomyces ha...
XP_013933018  34 WsAKR--YNV-GPQCIEPVyffnV---E------He-sTTP-LLRYM----KWGVTP---------KWA--NqksQK--- 81 
WP_014264679  28 L-PPN--YNI-APSTFQPI----Vr--Q------Er-dSSEREMVLA----RWGLVP---------FSA--R---SL--- 69  Granulicella ma...
5KO9_A        89 KLq------------------FNTTNCRSDTVME-KRSFKVPLGKgRRCVVLADGFYEW-Q----RcqGT-N-QRQPYFI 142 human
CDF80831      83 KY-------------------GGGLNARAEKLFN-HFIYKNAIHE-QRCIIPVTGFYEP-H----E--FE-K-KKYPFFI 132
WP_013870909  70 RKgfl--------------tkTNTLNARSENLFT-SPLFKEHIKT-QRCLILADGFFEP-H-------TRnK-ISYPHYI 124 Lacinutrix sp. ...
WP_015481161  70 RTdfl--------------akTNTLNATRERLFE-SDLYSQFIEG-QRCIIYADGFFEPh----eA--AGvQ-KKIPYFF 126 Polaribacter sp...
CCE80833     118 gksate------lkkvishleSRYFNCRKESLTS-SRVWNSAKKT--RCVVPIQGYFEWmK-------TK-G-KKTPYYV 179
XP_006684149 117 PLkevr------------kqqAMHFNCRRETLLQtSSIWNASKKT--RCVVPIQGYYEW-M----K--IK-T-QKVPYYV 173
XP_036664006 111 PVnkgkqnegekfsrelgkheSKYFNCRRESLAQhRAVWSSCKKH--RCVIPIQGYFEW-L----K--TK-N-AKVPYFI 179
Q6BHR8       122 PIerkgkpgpr-ysrelqkyqGKHFNCRKESLANkTPVWNSAKRT--RCVVPIQGYFEWiK-------SG-K-NKTPYFV 189 Debaryomyces ha...
XP_013933018  82 ---------------------LSTFNARYENIEH-SKIWSHCLDH--RCVIPIEGYFEW-K----T--DS-SkNKQPWFI 129
WP_014264679  70 ADfk----------------gFSTFNAKAETLSN-SPTWKAPLKS-RRCLVPADGFYEW-KaldsS--RK-P-KKQPYAI 126 Granulicella ma...
5KO9_A       143 YFpqikteksgsigaadspenwekvWDNwRLLTMAGIFD-------CW-EP-PEGg-------DVLYSYTIITVDSCK-- 204 human
CDF80831     133 QN-----------------------GNR-EPLSLAGIYT-------II-----GT----------YVTFSVITKVASP-- 164
WP_013870909 125 KY-----------------------RDS-NLFAFAGIYS-------EL----DDG----------LYTASIITTIAND-- 157 Lacinutrix sp. ...
WP_015481161 127 KE-----------------------KNH-ELFAFAGIYS-------KV-IEnNST----------TYAASIITTEAND-- 162 Polaribacter sp...
CCE80833     180 YP-----------------------KDS-SLLFLAGFYS-------HNsNFkNQEsd----dsDNISSFTIVTGPAHKad 224
XP_006684149 174 FS-----------------------KDQ-PLIYLAGFYS----------H--NKNftdnfnndQYLSTFTIITGPATKed 217
XP_036664006 180 HS-----------------------KTT-PLIFLAGLYShnynykeNF-N--VNN--------EYLSSFTVITAPAEKsd 224
Q6BHR8       190 HS-----------------------SKA-PLIYLAALYS----------H--NPNysnldshaKYLSSFTIITGPATKed 233 Debaryomyces ha...
XP_013933018 130 RR-----------------------KDH-KLMFLAGLYS-------IA----SDG----------KYEYTIITREAPK-- 162
WP_014264679 127 SL-----------------------TDD-EPMAFAGLWD-------AW-KE-PKSspq--tvdTWLQSFSIITTEANE-- 169 Granulicella ma...
5KO9_A       205 --GLSDIHH--------RMPAIL--DgE--EAVSKWLDF-GEVSTQE--ALK-L--I-HPTE-----NITFHAVSSVVNN 258 human
CDF80831     165 --LFAKIHNvk-----kRQPLIL--D-A--EHVKAWLSS--SVSDTQ--IKE-L--VnFNYSe---dKLHTYTVSKDVFS 222
WP_013870909 158 --FMKGIHNkpsrqgdyRMPLIL--D-K--SNEDDWLNG---NLSIDs-IRE-L--L-FTFTs---nDLVSYPVTKNVMN 219 Lacinutrix sp. ...
WP_015481161 163 --FFKAIHNkpnalgsyRMPLIL--D-P--STYETWLMA---TTTAE--VKT-V--L-DSFTq---qELVSYAVSTDVFS 223 Polaribacter sp...
CCE80833     225 vgDISWLHD--------RKPIILmaG-S--ESFHKWLDP-DVEWSDD--IYN-C--LeTSKnea-ysNIASYTVDQEVGN 286
XP_006684149 218 snDLSWLHS--------RKPIFL--K-PgtQQWDDWLDP-KVPWSHElqIAC-LdtLtNPAFe----SITCHKVSRDVGN 280
XP_036664006 225 kyDLSWLHT--------RKTLII--E-PgsKAWFRWLDP-TTDWDDS--LIEeV--LnSKTnea-yaNIEGYQVSNDVGN 287
Q6BHR8       234 skDLSWLHP--------RKPLML--M-PstNEWHEWLDP-EKDWSDS--LLDtS--L-NTIDnkaymNIEYHTVSSDVGK 296 Debaryomyces ha...
XP_013933018 163 --QLEWLHS--------RMPVVL--E-PgtDEFNSWLGLkDSNWDK---LSK-L--L-KVHEk---eDLEWYKVKKEVGN 219
WP_014264679 170 --LMSQVHT--------RMPVIL--S-Q--RDWAEWLDR----DGLRppPLH-L--L-KPYDs---dAMQLGPCNSAVGN 223 Granulicella ma...
5KO9_A       259 S 259 human
CDF80831     223 P 223
WP_013870909 220 S 220 Lacinutrix sp. 5H-3-7-4
WP_015481161 224 S 224 Polaribacter sp. MED152
CCE80833     287 T 287
XP_006684149 281 T 281
XP_036664006 288 P 288
Q6BHR8       297 P 297 Debaryomyces hansenii
XP_013933018 220 V 220
WP_014264679 224 V 224 Granulicella mallensis
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