Conserved Protein Domain Family
TMP-TENI

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pfam02581: TMP-TENI 
Thiamine monophosphate synthase
Thiamine monophosphate synthase (TMP) (EC:2.5.1.3) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate. This Pfam family also includes the regulatory protein TENI, a protein from Bacillus subtilis that regulates the production of several extracellular enzymes by reducing alkaline protease production. While TenI shows high sequence similarity with thiamin phosphate synthase, the purified protein has no thiamin phosphate synthase activity. Instead, it is a thiazole tautomerase.
Statistics
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PSSM-Id: 396919
Aligned: 80 rows
Threshold Bit Score: 132.662
Threshold Setting Gi: 81534115
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8G7X1  18 AYFVVGPEDCkGRPLTDVVDQALHGG-ATFIQLRAKEADASELTDMARDIAQIIEdnEKsdSVAFVIDDRADVVWQarrk 96  Bifidobacterium longu...
Q6FCY2   4 LYLITNDDPL--ELLLDKLEIALSTGhIAILQYRRKKVPKTDQAFEVEQIKVLCE--AY--QVPFVINDDLVLAAQ---- 73  Acinetobacter baylyi
Q8P5R7  10 VYLITPDTRD-TAQLLACTLPLLPH--ITWLQYRNKQADAALRLAQATALRAACT--AH--GVPLIINDDAALAQQ---- 78  Xanthomonas campestri...
Q9PGC4  37 IYLITPDETD-TARLIARTAPLLN-G-IVWLQYRNKLANTALRTEQAQALLALCR--QT--GIPLLINDDLELAQT---- 105 Xylella fastidiosa 9a5c
Q7W049  10 LYGITPEWDD-TDRLLAAVRAAAAGG-MTALQLRRKLADERLRAAQARALAPLCR--EL--GVVFLVNDHWKLALD---- 79  Bordetella pertussis ...
Q82UQ7  16 LYAITPDMAD-TGRLCDAVRQALAGG-VSWLQYRNKTADSRLRLVQAAEIHLLCR--QF--QVPLIVNDHLDLAME---- 85  Nitrosomonas europaea...
Q2YRC7  15 iVLVAPPIAD-GAALAKLLTAALSGGdVASVILDTGDLDEATFQAVAEKTVPVIQ--EK--GVAALILNDTRIAGR---- 85  Brucella abortus 2308
Q7CT79  31 LVLIVPQRDD-AQKQVTEVEDALRGGdVASVIIPQYGLDDAAFQKWAELIVPIVQ--AA--GAAALIAGDSRTASR---- 101 Agrobacterium fabrum ...
Q92M70  10 LVLVVPDIAD-SAERARLVGEALKGGdVASVIVPQYALSDADFQKHAEALVPVIQ--QA--GAAALIEGDTRVAGR---- 80  Sinorhizobium meliloti
Q9A3E0   7 LYLITPPALTdLADFGRQLARALEGGdVAALQIRLKDAPDDLVAAAVDVLGPIAQ--AR--DVAVILNDRPDLAAR---- 78  Caulobacter vibrioides
Q8G7X1  97 gIKVDGVHIGQTDMEPREARALLGDEAIVGLSAETESLvrlINELPDGCIDYIGAGPLHVSTTKPEASVGGNDGSGKTLD 176 Bifidobacterium longu...
Q6FCY2  74 -FDL-GVHLGQSDGEISDAVNRLTSGAVIGRTCLNSLVl--AEKAIADGATYIAFGAVYATATKPEAGNVGIEVIKQARQ 149 Acinetobacter baylyi
Q8P5R7  79 -VGADGVHLGEDDGEVAAARALLGASAIIGVSCYDEIEr--ARAAAAAGANYVAFGAFFPTATKVTTRRATPALLHEAAA 155 Xanthomonas campestri...
Q9PGC4 106 -IGADGVHLGMHDSNPSIARAQLGPHAIIGVSCYNQIEr--AKQAIKAGASYVGFGTFYPSHTKTTPYRATPELLRQTTH 182 Xylella fastidiosa 9a5c
Q7W049  80 -VGADGAHLGRDDADPATVRAQAGAGLLLGVSCYNDLRr--ADALLAAGADYVAFGTVFASPTKPEAVHAPLQTLTEARA 156 Bordetella pertussis ...
Q82UQ7  86 -IDAEGLHVGGDDISPAVARCHLGQDKIIGVSCYNQLDr--AIEAEEAGADYVAFGAFYPSMTKTGTYQAPIELLTAAKK 162 Nitrosomonas europaea...
Q2YRC7  86 -VGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRDRHg--AMEVGELQPDYLFFGKI-GADNKPDAHPRNLSLAGWWAE 161 Brucella abortus 2308
Q7CT79 102 -VKADGLHVGGNAEALAEAVENFTPKLIVGGGNADDRHk--ALEMGESNPDYVFFGKL-EGDIKPEAHPKNLALGEWWAS 177 Agrobacterium fabrum ...
Q92M70  81 -AKADGLHIAGGPDALADAIERHAPKLIVGGGNATDRHh--ALEIGELRPDYVFFGRT-DGDIKPEAHPKNLALAEWWAS 156 Sinorhizobium meliloti
Q9A3E0  79 -LPVDGVHVGQSDMACRDARKLMG-DRMVGVTCHDSRHl--AMEAAEAGADYVAFGAFFPTSTKDAPTRAEPDILTIWQE 154 Caulobacter vibrioides
Q8G7X1 177 AAQinticVasefPVVVGGGVTAADMAMLADTKAAGWFVVSAI 219 Bifidobacterium longum NCC2705
Q6FCY2 150 KFN-----T----PICAIGGLTVENSKVVIESGADLCAVISDI 183 Acinetobacter baylyi
Q8P5R7 156 LGL----------PRVAIGGITPSQVPELVTAGADLIAVVSGV 188 Xanthomonas campestris pv. campestris str. ATCC 33913
Q9PGC4 183 -LG-----V----PRVAIGGLTPKNIAPIIEAGAELLAVISGI 215 Xylella fastidiosa 9a5c
Q7W049 157 RVLacpa---prpAVVAIGGITPANVSQVAQAGADSAAVISGL 196 Bordetella pertussis Tohama I
Q82UQ7 163 KLG-----I----PVVAIGGIDLDNAGMLIASGCDAVAVSQAL 196 Nitrosomonas europaea ATCC 19718
Q2YRC7 162 MVE-----I----PCIAQAGSALESIVRAAETGADFVALGRAV 195 Brucella abortus 2308
Q7CT79 178 MIE-----I----PAIVMGGTDLSSVVAVSETGVEFVAMRSGV 211 Agrobacterium fabrum str. C58
Q92M70 157 MIE-----I----PCIVMGGTDPQSALAVAETGAEFVALRLAV 190 Sinorhizobium meliloti
Q9A3E0 155 TME-----T----PCVAIGGITVENASGLATAGADFLAVSAGV 188 Caulobacter vibrioides
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