1U05,1T8H,6DZD,7FBG,1RV9,1XFJ


Conserved Protein Domain Family
Cu-oxidase_4
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pfam02578: Cu-oxidase_4 (This model is not part of the current CDD release)
Multi-copper polyphenol oxidoreductase laccase
Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.
Links
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Statistics
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PSSM-Id: 515029
Aligned: 490 rows
Threshold Bit Score: 175.362
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1U05_A          20 STRIGGVSlpPYDSLNLGAHCGDNPDHVEENRKRLFAAg-nLpsKPvWLEQVHGKDVlklTG----------------E- 81  Shigella flex...
jgi:Bfae_10850  20 TGRSGGVSiaEHAGLNLARHVGDDEHAVERNRDLLAAAlg---tPVvFVDQVHSTDVhvlPRrg-------------eVp 83 
15_pfamImport    1 TDRRGGVSvgGFRSLNFGRTDVDELAALRTNMSLLRARlgiA--PLqTVHQVHGTMIr-hIDrvddlqgpegwlgdlvPg 77 
WP_012398546     6 EHDAVGVAftSVAEGNLAAHTGDEPAEVARRRRDLERVlgsG--PVrYVRQVHGTEVvdvTAtd-------------vPd 70  Kocuria rhizo...
WP_012892719     4 TDRHGGVSaePYGSRNLGGLCGDDPEAVAANRARTAAEfglD--RVvFMRQVHSADVryvSEp--------------fGe 67  Streptosporan...
WP_013169910    14 TTVNGGVSegVYASANLGFHVGDSESHVASNRQILERVlg---vPVvWMDQVHGVEIvnvKSe--------------vMr 76  Arcanobacteri...
WP_013423534     6 TDRSGGVSagPYAALNLGAHVGDDPAAVAANRRALAEItg---aSAcFMRQVHGAEVvtlSErtrad-------wfrdDa 75  Pseudofrankia...
Q0RNN6           6 TSRAGGVSvpPFGGLNLGDHVGDAEDAVAANRRRLAERlr---mPVqYMRQVHGTRVvvaRE----------------Pa 66  Frankia alni ...
Q2JD46           6 TSRSGGVSdpPFEGLNLGDHVGDADEAVAVNRRRLVDRlr---mPVqYMRQVHGRQVavlRR----------------Hg 66  Frankia casua...
WP_011719849    15 TTRDGGVShpPYASLNLSSQVGDDAGAVAANRERVRVRlgvP--AIvWQRAEHGGRVcv------------------vD- 73  Acidothermus ...

1U05_A          82 --PyASk----------rADASYSNTPGT-----VCAVMTADCLPVLF---CNRA---GTEVAAVHAGWRGLCAGVLEET 138 Shigella flex...
jgi:Bfae_10850  84 --V-VS------------ADAMVTDRDDV-----ALAIMVADCLPVLL---SDPR---RGVIAAAHAGRQGLLGGVLQRT 137
15_pfamImport   78 gaP-VPv-----------ADSIVCTLPDV-----PLAIRVADCVPVVL---ADVH---AGVIGAAHAGRVGLLTRVLQAT 134
WP_012398546    71 --T-APe-----------ADAAVS-TDGT-----PLGILTADCLPVVLvgrG--EggpAPLLGVAHAGRRGLLDGVLQNA 128 Kocuria rhizo...
WP_012892719    68 --D-PPp-----------LDGVCTDVPGL-----GLAALCADCAPVLL---ADPE---AGLVGAAHSGRVGTVLGVVPAL 122 Streptosporan...
WP_013169910    77 --R-DEhgsls----vgtaDGMILDYSNApetglALAVMVADCVPILI---VDRV---QNHAGVFHMGRAGMEQGTMRHA 143 Arcanobacteri...
WP_013423534    76 lgS-APeraaargadsrgEDGLVTDVPGL-----ALTVLVADCVPVVF---TAAG---A--VGVAHAGRAGLATGVVPAT 141 Pseudofrankia...
Q0RNN6          67 --P-PPe-----------ADALVTDVPGL-----ALAVMVADCAPVLF---ESPT---A--VGVAHAGRAGMTDGVIDAT 119 Frankia alni ...
Q2JD46          67 --P-PPq-----------ADALVTDVPGL-----VLAVMVADCAPVLF---EAPA---V--VGVAHAGRVGMASGVIHAT 119 Frankia casua...
WP_011719849    74 -----Alrdra---aepsADGLIVLAPGC-----AVAALAADCVLFVL---ADRA---GRAVGVGHCGWRGLLAGIVGAV 134 Acidothermus ...

1U05_A         139 VSCFAD---KPENILAWLGPAIGPRAFEVGAEVREAFMAVDAkASaAFIQHGDKylADIYQLARQRLANVGV--EQIFG- 212 Shigella flex...
jgi:Bfae_10850 138 VEEMAAlgaRAEDLEASIGPAICGACYEVPAAMREEAAAVLP-ET-WARTSRGTpsLDLRAGAVAVLEAAGVprTAIDA- 214
15_pfamImport  135 VDAMASrg--aTSLEAWVGPHICGRCYEVPDDMAAQAYRALP-AL-RARSRWHTasLDLGAGTQAVLEAAGV--RVHRV- 207
WP_012398546   129 VHALRErgaR--EVTAWIGPAVCGSCYEVPEAMAQDAERSLP-GI-ATTTSWGTpgLDLPAAARAVLEAHGV---RIDPa 201 Kocuria rhizo...
WP_012892719   123 VAEMTArgaDPASMTALIGPMACGSCYEVPAELRGQVAAALP-EA-WSITRQDTpaLDLRAAITSQLAKAGV--GEITH- 197 Streptosporan...
WP_013169910   144 IARFLElgsHPENLHVLMGPHICGKCYEVSLGVYEA--SPME-AR--CVTRWGTrgIDVVAGGRVQATAYNV---EVSV- 214 Arcanobacteri...
WP_013423534   142 VAALADlgaAPQHLHVEVGPSVCGRCYEVPAAMRDEVEALVP-GT-ATVTRAGSpaLDLRAGVAGQLRDLGV--TDITV- 216 Pseudofrankia...
Q0RNN6         120 LAAFDRlgvPADRLTVTIGPCVCAGCYEVPAELRREVEQRVP-GS-AAATRRGTaaIDLRAGIHHQLTAAGV--TDIAV- 194 Frankia alni ...
Q2JD46         120 LGALERlgaARDELRVTIGPCICAGCYEVPEDLRCEVDTQVP-GS-AATTRVGTaaIDLRAGIRRQLAAAGV--TDITI- 194 Frankia casua...
WP_011719849   135 VDGVRAaagDGAPLHAVLGPAICGSCYAVGPEVYAAVTGTVP-AA-AARTLSGRlaLDVAAGVAAQLRDHGVviD----- 207 Acidothermus ...

1U05_A         213 --GDR--CTYTENET-FFSYRRDK----TTGRMASFIW 241 Shigella flexneri
jgi:Bfae_10850 215 --EHP--CTL-EDER-FYSYRRHP----RTGRFAGVLR 242
15_pfamImport  208 --DP---CTL-EHPDtLFSHRGSRg---RAGRQIGLIW 236
WP_012398546   202 cdDRRawCTL-EHPD-LFSYRRGAt---P-GRIAGLVW 233 Kocuria rhizophila
WP_012892719   198 --DTR--CTI-ETPD-LFSHRRDR----TTGRFAGYVW 225 Streptosporangium roseum
WP_013169910   215 --SSE--CTYEHDL--FYSHRRAThegvTTGRFAGIAC 246 Arcanobacterium haemolyticum
WP_013423534   217 --SGR--CTM-EDPA-LFSHRRDAg---RTGRFAGVAW 245 Pseudofrankia inefficax
Q0RNN6         195 --ATR--CTA-EDPE-LYSYRRDG----RTGRFAGVAW 222 Frankia alni ACN14a
Q2JD46         195 --SAR--CTA-EDPE-LYSYRREG----RTGRFAGLAW 222 Frankia casuarinae
WP_011719849   208 --NRIggCTY-EDAA-FFSYRRDG----VTGRHAVLAW 237 Acidothermus cellulolyticus
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