4CCZ,5DMN,8SSC,1UMY


Conserved Protein Domain Family
S-methyl_trans

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pfam02574: S-methyl_trans (This model is not part of the current CDD release)
Homocysteine S-methyltransferase
This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.
Statistics
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PSSM-Id: 515025
Aligned: 600 rows
Threshold Bit Score: 99.5828
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4CCZ_A                18 MV---------------------LDGGMGTMIQRE--KlNEEhFRgqefkdharplkgNNDILsiT---------QPD-- 63  human
XP_014539073           1 -----mgalsktlpqlassklfitEGGIETSL------------------------------------------------ 27 
goetting:Curi_c17190  27 lyiieevipmnfetcfqissailMEGALGERL------------------------------------------------ 58 
WP_011767539          16 FV---------------------SDGGMETTL------------------------------------------------ 26  Azoarcu...
WP_012161514           1 ------mpqyrqnlpqlssdvflTDGGLETTL------------------------------------------------ 26  Acaryoc...
WP_012694899           1 ----------mkgplpqltrrvltDGGLETDL------------------------------------------------ 22  Deinoco...
P74718                29 IIandklavkmtnlphqceqiflLDGGLETEM------------------------------------------------ 60  Synecho...
XP_003958172          18 LV---------------------LDGGQGTELEKRgiNiSSP-VW-------------STLPF--Inesf-wsnsSSNdr 59 
XP_003686967          17 LV---------------------LDGGQGTELENRgvNiNSP-LW-------------STISF--VndkfwdeniENTer 59 
XP_001642555          17 LV---------------------SDGGLGTLLESRgiNvSSP-LW-------------STVPF--LkddfwdsetKTSdr 59 
4CCZ_A                64 -V-------------------------IYQIHKEYLL-AGAD----IIETNTFSSTSI---AQAdyG---L-E--HLAYR 103 human
XP_014539073          28 -Iyrknidipgfst-lpllgteegrktILSIYQDYVKiALAHstgiVLETRTWRGSp--------aWsstIgLsvTQIVD 97 
goetting:Curi_c17190  59 -KreysvefddkvamaglvynthsreaMESIFKEYVTiAEKYklpfIATTPTRRAN--------------L----EHVMQ 119
WP_011767539          27 -Iyhhgrelphfaa-ftlmddaegrrlLTDYYRRYIDiALRHrrglLLETPTWRASa--------dWgarLgYdaAALAR 96  Azoarcu...
WP_012161514          27 -Ifhegidlpdfaa-fdllkdnqgyeaLYEYFQTYAQlAQTYevglILESATWRANp--------dWgtkLgYdaAELAA 96  Acaryoc...
WP_012694899          23 -Lfnrgidlplfss-vvllatlegreaLETYYRPYLElAHRHsagfILESATWRASp--------dWaapLgLhqCGLDQ 92  Deinoco...
P74718                61 -Ifnrgfdlpafaa-htllsdplgreaLKNYFHGFLDlAKEKqfgfLIDAPTWRAQp--------fFaeeLgVslEEIRQ 130 Synecho...
XP_003958172          60 kI-------------------------IKDMYSDFIS-AGAD----VLSTTTYQTSFAsisENTn-Iq--T-LkdYHE-- 103
XP_003686967          60 kC-------------------------IREMFNDFKD-AGAN----VFSTLTYQTSFSsvsENTd-Ik--S-LqeYHE-- 103
XP_001642555          60 nI-------------------------IEGIYRDYIT-SGSR----ILSTITYQTSFAlisTHTe-Vk--T-IegYKQ-- 103
4CCZ_A               104 ------MNMCSAG--VARKAAEEVtlqtgikrfVAGALGPTNKTLSV---S-P-SVErpdyrnITFDELVEAYQEQAK-G 169 human
XP_014539073          98 ------LNRIAVR--ILRDLRHKAetps-tpivISGALGPLQDAYQD--------STg----rFTFSQAREHYGAQIRvF 156
goetting:Curi_c17190 120 sefdekIIEDNVR--FLQKIKTYAstd----mfVGGLMGCKGDAYKA---------Te----iLSIQEAHKLHSWQANlF 180
WP_011767539          97 ------VNRDSVA--LLDALRATHqrag-tpmvISGAIGPRGDGYVA---------Da----gMSATEAADYHGEQIAtL 154 Azoarcu...
WP_012161514          97 ------VNRNAIA--LLHTIRQQYetea-srmvISGCIGPRGDGYQV---------Dt----aMTPAEAQVYHLPQIEaF 154 Acaryoc...
WP_012694899          93 ------LNVAAVE--LLHRLRSKSatdp-leivVSGCVGPRGDGYDP---------Gq----iMNVAEAANYHGHQVRvL 150 Deinoco...
P74718               131 ------ANFRAVE--FARALKQAYvnei-qpllINGLIGPCGDAYGG---------Eh----fSNAEAAQVYHRQQISwL 188 Synecho...
XP_003958172         104 ------LLNRITkftRECIGDSKY---------LVGSIGTYAAYLSaeytGdFgDA-------ADTIDYHGYFKPQLDnF 161
XP_003686967         104 ------LLRKITgfcRRCISDDDY---------LLGCIGAYAASIGaeydGnYgLF-------AGKIDYLKYFKPQLDeF 161
XP_001642555         104 ------LIRNITsfcRSAIGEDNY---------LIGSIGPFGARLGaeytGnYgDS-------PSNINYLEYFKPQLEeF 161
4CCZ_A               170 LLDGGVDILLIETIFDTANAKAAl--fALqnlfeekyaprPIFISGTIvDKsgR-TlSGQTGEGFVISVSHG-E------ 239 human
XP_014539073         157 -AEEGVDMSSIMTVTNLDEATAAvsvaREyn--------lPILVSFSIetd--grLrGGRTLEDAIREVDRVtD------ 219
goetting:Curi_c17190 181 -KNSGVDFLFAGIMPALSEAIGMakamENtg--------lAYIISFMIrnn--grLiDGTTIHDAILSIDNEtL------ 243
WP_011767539         155 -ASTRCDLVTAFTLNYVDEAIGIvraaQHet--------mPVVISFTLetd--grLpSGQALGDAIRETDAAtA------ 217 Azoarcu...
WP_012161514         155 -KEAEADMVSAVTMTYTEEAIGItraaHLvg--------mPVVISFTVetd--gkLpTGQGLKDAIAQVDAAtG------ 217 Acaryoc...
WP_012694899         151 -ASAGVDMLSALTMTNINEATGItlaaAEvg--------lPVSVSFTVetd--grLpTGDSLMDAVTAVDEAtN------ 213 Deinoco...
P74718               189 -AEAGVDLLGAFTLTSVNEAIGIvrasQEfs--------lPVSISFTVetd--grLpTGTALSEAIAIVDEAtN------ 251 Synecho...
XP_003958172         162 NRSTEIDIIGFETIPNIHELRAIl--sLNkkd-----lskPFYISLSTnSK--AqLrDGTSLKG-VVDVIKSfEstlnpn 231
XP_003686967         162 NNDMNIDIIGFETIPNKHELEAIl--sWDedi-----inrPFFIALSLsDK--NgLrDGTSFEE-MGRLFAKyKgrn-kn 230
XP_001642555         162 NNNDDIDIIGFETVPNKYELEAIl--sWDksv-----iskPYYVSLSLlDN--GgLrDGTSFEE-IATIFKKySnn--dn 229
4CCZ_A               240 PLC--IGLNCALgAAEMRPFIEIIgk-----ctT-AYVlCYPN-------------AglpntFGD-------------YD 285 human
XP_014539073         220 NYTtyFGVNCAH-PRHVMIALRGMsedvm-----srigsIRGNsslkchdeldnsgVl---dRGD--------------- 275
goetting:Curi_c17190 244 RKPicYMANCVH-PIVLKKALSCScnetklvkerfRGI--QANtsqlspeeldnsdDl---kTSDsislacnmmelndY- 316
WP_011767539         218 AGAtyYMINCAH-PTHFDHVLDGAgdwrh------rirgLRANascrshaeldaatEl---dAGD--------------- 272 Azoarcu...
WP_012161514         218 NGPiyYMINCAH-PSHFEQIFATNepwlt------rihgLRANastkshaeldeavDl---dDGN--------------- 272 Acaryoc...
WP_012694899         214 DYAayFMVNCAH-PDHFAAVLDEPaawtr------rirgVRANasrcshkeldamtEl---dAGD--------------- 268 Deinoco...
P74718               252 QGAayFMVNCAH-PDHFRAVIREEawls-------rlggFRCNpsrrshaqldqanFl---dIGN--------------- 305 Synecho...
XP_003958172         232 LIL--LGINCIG-LNSSHLTMEYLnnhl--pqfP---LiVYPN-------------S------GEk------------YD 272
XP_003686967         231 LVY--VGGNCIS-YAYSIDNIRKLhdiv--phlN---LiAYPN-------------S------GEi------------YD 271
XP_001642555         230 LIL--TGANCIS-FKYASENISKLhqai--ptlP---LiVYPN-------------S------GEi------------YD 270
4CCZ_A               286 ETPSMMAKHl----------KDFAMDGl-VNIVGGCCGSTPDHIREIAEAV 325 human
XP_014539073         276 --IPVWDQEf----------NGLLNILlgLKVIGGCCGTDEEHVETIAKRI 314
goetting:Curi_c17190 317 LTPK---------------------------IFGGCCGTDNTHIEEIAKRL 340
WP_011767539         273 --PIDLGARy----------RALRPQLpgLAVIGGCCGTDHRHVEAICAAY 311 Azoarcus olearius
WP_012161514         273 --PQELGQQy----------LNLSDALpnLNVLGGCCGTDHRHIEAICKAC 311 Acaryochloris marina
WP_012694899         269 --PLELGQLy----------RKLLHEHpqITVLGGCCGTDLRHVTAIAEAC 307 Deinococcus deserti
P74718               306 --PVELAHSy----------WTLKQKVpsANVFGACCGSDLRHIREIAKVF 344 Synechocystis sp. PCC 6803
XP_003958172         273 PVRKIWLAdedpaftweyivhrYLDAG--ARIVGGCCRTTPSDIRSISEAI 321
XP_003686967         272 QKSKQWSStsaikisweevvneYADAG--VKIIGGCCRTTPDDIKQIKKAV 320
XP_001642555         271 PLTKKWTIdqtfgltwedlikeLRTSN--VRIVGGCCRTTPDDINKIKDMI 319
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