1G5T


Conserved Protein Domain Family
CobA_CobO_BtuR

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pfam02572: CobA_CobO_BtuR 
ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis. These enzymes catalyze the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.
Statistics
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PSSM-Id: 396911
Aligned: 456 rows
Threshold Bit Score: 130.548
Threshold Setting Gi: 524401405
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1G5T_A          27 ERGIIIVFTGNGKGKTTAAFGTAARAVGHGKNVGVVQFIKGtwPNGERNLLE-Ph--gVEFQVM--ATGFT--WETqnRE 99 
jgi:Palpr_2574   2 KNGLLQVYTGDGKGKTTAAFGMAFRAHGRGFKVGVVQFMKTr-aTGEVMLAQtLenffVKRIDTs--PKFTwdMNEaeLV 78  Paludibacter ...
CCP26609         2 EKGYVQVYTGNGKGKTTAALGLAFRAAGRGMKVIMFQFLKGm-DTGELKAAElLkp-nFEIRRFaeSKKFTwnLTKeeFD 79  Tepidanaeroba...
Q8RCP8           2 KKGYVQVYTGDGKGKTTAALGLAFRAVGRGMKVIMFQFLKGm-ATGELKSAElLkp-nFEIKRFaeSKKFTwdMTEeeLQ 79  Caldanaerobac...
WP_013657934     2 ENGLVQVYYGTGKGKTTAAIGLGVRAIGNDYKVIMIQFLKNd-mTGECRVLKdLep-yFKVFHFekRRGFTwqLNPeeKQ 79  Cellulosilyti...
WP_013361192     3 NQGLIHVYTGDGKGKTTASVGLGMRAAGRDFKVVMVQFLKSs-DTGELKVIEkLd--nFEVHRFerPRGFFwtLNDkeKL 79  Acetoanaerobi...
WP_025435989     3 gKGLIQIYTGDGKGKTTAAIGQGIRACGRGCRVIMVQFLKTs-DSGELEIIKkId--gFDVFRFqtQEGFYwnLDEagRS 79  Peptoclostrid...
EDK32768         5 KKGFIQIYTGDGKGKTTAALGLALRAAGNNYRVCMVQFLKTs-RTGEIESAKkLeg-nFKIYRFekKKGFFwtLNDceKE 82  Clostridium k...
jgi:Clopa_1209   5 SKGYVQIYTGNGKGKTTAAVGLGVRAAGDGYSVFMVQFLKSg-STGELESIKkLep-nFKVFRFekKRGFFwtLNDseKA 82  Clostridium p...
Q8XJ53           5 KEGYVQVYTGNGKGKTTAAMGLAFRAAGDGMEVKVVQFLKSw-KTGELESAKrFd--nLEILRFekVKGFTweLNEeeLA 81  Clostridium p...
1G5T_A         100 ADTAACMAVWQHGKRM--LADPlLDMVVLDELTYMVAYDYLPLEEVISALN-ArPGHQTVIITGRGCHRDILDLADTVSE 176
jgi:Palpr_2574  79 ELKATIREGFFLICEL--VKAAeYDMLILDEFNHIIVQGFVTKEEVLELID-AkPDTMEIVMTGRNAPDWLMERADLVTE 155 Paludibacter ...
CCP26609        80 NLKQNVKDEYNQLAAV--IKSKnYDIVILDEVMAAMHGGLLTVQEVERLIE-EkPETVELILTGRDVPQEIIEKADLVTE 156 Tepidanaeroba...
Q8RCP8          80 ELKSKVREEYEELLRI--LKSGeYDIVIVDEAMAAIHSGLLSVEDVLRLIE-EkPKSVELILTGRSAPQEIIEKADLVTE 156 Caldanaerobac...
WP_013657934    80 ELRSETTNALKFASKVmdTGE--CDVLILDEVLNSVESGIISEDELYELICnK-SDDVELVLTGRKLPIRIAEKADYISH 156 Cellulosilyti...
WP_013361192    80 ELQEDIDKAMQFVKDR--LESGdCDLLILDEVMGSIKNKLIDVDKLVSMLK-NrKPHMEVVLTGRNVPAEIVEIADYVSE 156 Acetoanaerobi...
WP_025435989    80 RVEAETKAALEFAERV--MADKkCDILILDEILGALSNGLVKLDSLIRLLG-NkPEGMEVVLTGRGAPEELIEKADLVTQ 156 Peptoclostrid...
EDK32768        83 ELKKEVKKVYEFCLKA--LENNtCDILIMDEVMAILSNRLLSVEEIIKLID-KkPDNMELILTGRNVPEEILQKADLVTE 159 Clostridium k...
jgi:Clopa_1209  83 ELKLEVQEAYRFCLDT--LKNNkCDILIMDEIMGALSNELVSKEQLLQLIE-AkPHNMELILTGRNVPEEIIDRADLVTE 159 Clostridium p...
Q8XJ53          82 QLKAEVRVGFDFVKGL--VETRgCDILILDEVMASISGGFIGEDEIVELIE-KkPKDMELILTGRNVPEKIMEKADLITE 158 Clostridium p...
1G5T_A         177 LRPVKHAFDAGVKAQMGID 195
jgi:Palpr_2574 156 MKCIKHPFDKGIPARVGIE 174 Paludibacter propionicigenes WB4
CCP26609       157 MREVKHYFKIGVPARVGIE 175 Tepidanaerobacter acetatoxydans Re1
Q8RCP8         157 MKEIKHYYKKGVPARVGIE 175 Caldanaerobacter subterraneus subsp. tengcongensis
WP_013657934   157 IDDIKHPTEKGRDARAGIE 175 Cellulosilyticum lentocellum
WP_013361192   157 INPIKHPFEKGIPARRGIE 175 Acetoanaerobium sticklandii
WP_025435989   157 MQKVKHPLDKGIGARRGIE 175 Peptoclostridium acidaminophilum
EDK32768       160 MKNIKHYMDKGILAREGIE 178 Clostridium kluyveri DSM 555
jgi:Clopa_1209 160 MKEIKHYFGKGVPAREGIE 178 Clostridium pasteurianum BC1
Q8XJ53         159 MREIKHYYKKGVPAREGIE 177 Clostridium perfringens
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