1OU0,2AFR


Conserved Protein Domain Family
CbiC

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pfam02570: CbiC 
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Precorrin-8X methylmutase
This is a family Precorrin-8X methylmutases also known as Precorrin isomerase, CbiC/CobH, EC:5.4.1.2. This enzyme catalyzes the reaction: Precorrin-8X <=> hydrogenobyrinate. This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyzes a methyl rearrangement.
Statistics
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PSSM-Id: 396909
Aligned: 392 rows
Threshold Bit Score: 119.797
Threshold Setting Gi: 74559602
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1OU0_B                     14 EERSLAAIDSXIDPD-ISGPXRHIVVKAIHAAGDFAIAPLIRYSDGFFKSXLAKLKEGCTIICDSEXVRAGIySRPVLE- 91  Th...
jgi:Cyan7822_3293           7 dAQSLAIIDHEIGQTsLAPAEYEIARRVIYETADFEYLSLIRFADRALPAGGAALAARSTIVVDVPMVQVGI-VPNLQRt 85  Gl...
WP_015224476                7 EANSLLAIDQEVGKHrFSPAEYEIIRRVIYETGDFDYLSHIHFSDRALSAGAAALAARTAIVVDVPLIQAGI-TQCAQNs 85  Ha...
WP_015168121                7 dvqgLAVIDAELDG--YQPAQYEIIRQVIYATADFEYKDLIQFSDQAIEKGTAAIAARTSIVVDVASVQITV-APILQSt 83  Sy...
jgi:Sta7437_1525            7 dAQSLAIIDQEISTHqLSPAQYEIVRQIIYSTADFDYLHLLRCSADALFHGAAALAARTPIIVDVPMIQVSL-VPLLQQt 85  St...
P74152                     21 dAQNLATIDYEIGDHgHSPAQYEILRRVIYATGDFEYLNLLHFSARVLTVGAAALASRTTILVDVPMVQVGI-VPTLQKt 99  Sy...
jgi:Cal6303_3429            7 dAQSLAIIDHEIGDRlISPAEYEITRRVIYATGDFEYKSLINFSERAIQSAVAALSARTTIVVDLPMIQAGI-AYEIQEt 85  Ca...
jgi:Syn6312_2218            7 diQSLHQIDQELGDHpFAPAEYEIIRRVIYATGDFDYQTLIQFCPQALSAGVAALSVRTPIIVDVPLVQMGI-LPQLQTt 85  Sy...
Q8DK06                      7 dvtQLRLIDQLLAGHhLSPAQYDITRRVIYATGDLEYQNLIVYSEQALQSGVAALAAHTPIVVDVTMVQVGL-LSYTQNt 85  Sy...
dbpsupku:SYNPCC7002_A0528   8 dAQSLALIDREIGKHsFSPAEYEIVRQVIYCTADFEYAQLIHFSEHALQAGAAALAARGTIIVDAPMVRVGI-TEQLQNs 86  Sy...
1OU0_B                     92 -RNRVVCYLNDVrskeXADVNGITRSAAGIRIAXQdhrnsVIVIGNAPTALLEAXRXIEE---NGWydiPIVGIPVGFIN 167 Th...
jgi:Cyan7822_3293          86 fANPVYCSTETI----TRPQKGKTQAAWGMQTLARrypeaIFVIGESQTALVGLVELIEEeniKPA---LVIGTPAGFVG 158 Gl...
WP_015224476               86 fANPIYSHVPNH-------------RSHKLKVLAQrypeaIFIIGKEQSAFSTFFQLLEKeeiQPA---FAIITAPKLVD 149 Ha...
WP_015168121               84 fANGVYACTGVI----TRPQRYKSQAAWGMETLAQrypsgIFVVGESQSALETLVNLMTSqviAPS---LVIATPSEFVN 156 Sy...
jgi:Sta7437_1525           86 fCNPVYCCTTAV----TRPPIKQTKAAWGLEILAKqhpngIYIIGQDESALTNLVQLIDSktiEPA---LAIATPPLFLN 158 St...
P74152                    100 fANPVYCATQSI----TRPQKERTEEAWGILNLAHrypdgIFVIGHAQTALDALMELVEAqriQPA---LVIATATNFGD 172 Sy...
jgi:Cal6303_3429           86 fANPIFCGLERM----NRPQNAQTNAAWGLETLARrypegIFVIGQAQTALTALMSLIETqeiKPS---LIIATSPNFND 158 Ca...
jgi:Syn6312_2218           86 fANPVYCGSETF----TRPQTEKSRAAFGVETLSRrhptaIFVIGASQTTLSPLLELVQAdeiKPA---LIIHTPVGFL- 157 Sy...
Q8DK06                     86 fGNPIYCGAETF----TRPQQEKSRIAFGVETLARrhptaIFVLSSDHSALEPLLTLVEAqeiRPA---LIIDAAPNFL- 157 Sy...
dbpsupku:SYNPCC7002_A0528  87 fANPVYCSADTL----TRPQREKTKTAWGMETLARrypeaIFVIGQSQTALSSLVTLVKKgiiRPA---LVIFTPANFLT 159 Sy...
1OU0_B                    168 ASKAKEGLVsshiEYISVEGHRGGSPIAASIVNG 201 Thermoplasma acidophilum DSM 1728
jgi:Cyan7822_3293         159 ADVAKQRLHdaevPYICVYGRKGSPVVAVAIVNA 192 Gloeothece verrucosa PCC 7822
WP_015224476              150 VDNIESKLAaltiPHIRVTGKKGSASVAVGIFNG 183 Halothece sp. PCC 7418
WP_015168121              157 VGIAKSQLQrssiPYILINGQKGGAMVAAKILNA 190 Synechococcus sp. PCC 7502
jgi:Sta7437_1525          159 PVQ-KQWLEncaiPHIYLNSRKGGAIVAASIINS 191 Stanieria cyanosphaera PCC 7437
P74152                    173 RQDVELNLQkaniPHIIVQGRKGGTEVAVAIITA 206 Synechocystis sp. PCC 6803
jgi:Cal6303_3429          159 VNSNQEQLQnsliPNITINSNKGNAVVATAILDA 192 Calothrix sp. PCC 6303
jgi:Syn6312_2218          158 -PQGREQLEkswlPNIMLNGQKGGPGVAAAILSG 190 Synechococcus sp. PCC 6312
Q8DK06                    158 -PPTLDRLQnswvPHIAIKGSKGGVSVATAIMNG 190 Synechococcus elongatus
dbpsupku:SYNPCC7002_A0528 160 GTAPQKYLEeaaiPHICMQSRKGGATVAVAIING 193 Synechococcus sp. PCC 7002
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