6ACA,6M6A,2LWJ


Conserved Protein Domain Family
CarD_TRCF_RID

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pfam02559: CarD_TRCF_RID (This model is not part of the current CDD release)
CarD-like/TRCF RID domain
This is the RNA polymerase interacting domain (RID) of transcription-repair-coupling factor (TRCF), CarD and CarD homologue in Myxococcus xanthus, called CdnL. In Myxococcus xanthus, CdnL is a protein required for the activation of light- and starvation-inducible genes. It interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus. CarD is widely distributed among bacteria and represents a distinct class of RNAP binding proteins that regulate transcription and essential processes. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription.
Statistics
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PSSM-Id: 515013
Aligned: 653 rows
Threshold Bit Score: 33.2231
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ACA_A         538 LTAGDLVVHDQHGIGRFVEM-------VErtvggaRReYLVLEYASakrgggakntDKLYVPMDSLDQ--LSRYV 603  Mycobacterium tub...
Q5WHC5           4 FKVGDKVVYPYHGAGTIQEVeekdvlgET------HL-YFILHFPLv--------dITLMLPESRIEQsgLRKVI 63   Bacillus clausii ...
Q9KD36           2 FKIGDHVVYPFHGAGVVQDIeekeilgET------HS-YFVLHFPLt--------dIKVMLPKHRIQQsgLRKVI 61   Bacillus halodurans
CDC18398         2 FNVGDRVVYPMYGAGVIEGIetrevdgQE------LS-YYVLHIPIg--------dLKILISKNKADIlgLRALn 61  
WP_022289561     2 FSVGDLVVHPMHGAGVIDDIvrervagST------QE-YYVFKMPVg--------gLLLKIPIAKSQLigLRAII 61   environmental sam...
48_pfamImport    1 FCVGDKIVHPMHGAGVIESIvdekigrDL------VR-FYVFRMPVs--------gLTLKIPTANSEMigVRAVS 60  
CDA82292         2 YGIGQRVVHPMHGAGVIENVteellygAA------RT-YYVFRQAVs--------gLVLKLPTDNCEAigVRLLY 61  
52_pfamImport    1 FLIGDKVVHPMHGAGVIERItherlgsCV------SS-YYVFRMPSg--------gLVLKIPTDACCQigLRCLS 60  
WP_013695162   109 YKIKDYVIYPKHGIGQITAVekdtiagID------IN-FYKIEITKd--------kLVLTIPTNQQGH--LRSLS 166  Candidatus Pelagi...
Q4FNJ4         109 YKVKDYVVYPKHGVGQITEFkkiniggID------VE-TYVLKFEKd--------kANGMVPVNKQSH--LRPLA 166  Candidatus Pelagi...
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